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© Institut Pasteur
Cristaux de cellulase, enzyme purifiée de Clostridium thermocellum permettant la digestion de la cellulose. Image colorisée.
Publication : Journal of virology

Mechanism of the antiviral action of 1-beta-D-arabinofuranosylcytosine on Borna disease virus

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of virology - 01 Apr 2005

Volmer R, Bajramovic JJ, Schneider U, Ufano S, Pochet S, Gonzalez-Dunia D

Link to Pubmed [PMID] – 15767452

J. Virol. 2005 Apr;79(7):4514-8

Borna disease virus (BDV) is a nonsegmented, negative-stranded RNA virus that causes neurological diseases in a variety of warm-blooded animal species. Recently, we showed that the nucleoside analog 1-beta-D-arabinofuranosylcytosine (Ara-C) was a potent inhibitor of BDV. This finding was surprising for an RNA virus, since Ara-C is a DNA polymerase inhibitor. Thus, we sought to better define the mechanism of action of Ara-C on BDV. Here, we show that (i) this effect is specific for an arabinoside ring carrying a cytosine base, (ii) it requires phosphorylation of the nucleotide, and (iii) it can be reversed by an excess of cytidine. Using the recently described minigenome assay for BDV, we provide evidence suggesting that Ara-C may act as a competitive inhibitor of the BDV replication complex.

http://www.ncbi.nlm.nih.gov/pubmed/15767452