Timeline

Hugo Mouquet
Head of Structure
04 Sep 2024
publication

Intestinal newborn regulatory B cell antibodies modulate microbiota communities.

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02 Sep 2024
publication

Sustained HIV remission after allogeneic hematopoietic stem cell transplantation with wild-type CCR5 donor cells.

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19 Jul 2024
publication

Broad sarbecovirus neutralization by combined memory B cell antibodies to ancestral SARS-CoV-2.

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01 May 2024
publication

[IgA antibodies against HIV-1].

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11 Jan 2024
publication

Early antiretroviral therapy favors post-treatment SIV control associated with the expansion of enhanced memory CD8+ T-cells.

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05 Jan 2024
event

Group de Reflexion SIDA (GRS) seminar: “New insights in the regulation of HIV expression and latency”

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13 Dec 2023
publication

High fusion and cytopathy of SARS-CoV-2 variant B.1.640.1.

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02 Nov 2023
publication

SARS-CoV-2 viral persistence in lung alveolar macrophages is controlled by IFN-γ and NK cells.

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25 Oct 2023
publication

TMPRSS2 is a functional receptor for human coronavirus HKU1.

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10 Oct 2023
event

Groupe de Réflexion SIDA (GRS) meeting: “HIV sensing, nuclear import, and latency”

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10 Oct 2023
publication

HIV-1 treatment timing shapes the human intestinal memory B-cell repertoire to commensal bacteria.

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06 Oct 2023
publication

Mucosal application of the broadly neutralizing antibody 10-1074 protects macaques from cell-associated SHIV vaginal exposure.

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24 Aug 2023
news

New publication – Anti-V1/V3-glycan broadly HIV-1 neutralizing antibodies in a post-treatment controller

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06 Jul 2023
publication

Anti-V1/V3-glycan broadly HIV-1 neutralizing antibodies in a post-treatment controller.

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15 Mar 2023
project

CoVariant – Comprendre les déterminants de l’immunité muqueuse et optimiser le diagnostic de l’infection aux variants du SARS-CoV-2

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14 Feb 2023
publication

Resistance of Omicron subvariants BA.2.75.2, BA.4.6, and BQ.1.1 to neutralizing antibodies.

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03 Feb 2023
publication

Tocilizumab treated convalescent COVID-19 patients retain the cross-neutralization potential against SARS-CoV-2 variants.

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21 Dec 2022
publication

Full-Lung Prophylaxis against SARS-CoV-2 by One-Shot or Booster Intranasal Lentiviral Vaccination in Syrian Golden Hamsters

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21 Dec 2022
publication

Full-Lung Prophylaxis against SARS-CoV-2 by One-Shot or Booster Intranasal Lentiviral Vaccination in Syrian Golden Hamsters.

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17 Nov 2022
publication

Longitudinal analysis of serum neutralization of SARS-CoV-2 Omicron BA.2, BA.4, and BA.5 in patients receiving monoclonal antibodies.

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02 Nov 2022
event

Groupe de Reflexion SIDA (GRS) meeting: “Role of membraneless organelles in viral replication”

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01 Nov 2022
publication

Evolutionary trajectory of receptor binding specificity and promiscuity of the spike protein of SARS-CoV-2.

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19 Sep 2022
publication

The Spike-Stabilizing D614G Mutation Interacts with S1/S2 Cleavage Site Mutations To Promote the Infectious Potential of SARS-CoV-2 Variants.

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27 Aug 2022
publication

IRF8 regulates efficacy of therapeutic anti-CD20 monoclonal antibodies.

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21 Jul 2022
event

Groupe de Reflexion SIDA (GRS) seminar: “Functional and structural studies of the T cell response against two major human viruses: HIV-1 and SARS-CoV-2”

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07 Jul 2022
publication

NK cell spatial dynamics and IgA responses in gut-associated lymphoid tissues during SIV infections.

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04 Jul 2022
publication

Potent human broadly SARS-CoV-2-neutralizing IgA and IgG antibodies effective against Omicron BA.1 and BA.2.

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28 Jun 2022
publication

SHLD1 is dispensable for 53BP1-dependent V(D)J recombination but critical for productive class switch recombination.

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17 Jun 2022
news

New publication – Potent Human Broadly SARS-CoV-2 Neutralizing IgA and IgG Antibodies Effective Against Omicron BA.1 and BA.2

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01 Jun 2022
publication

Serum neutralization of SARS-CoV-2 Omicron sublineages BA.1 and BA.2 in patients receiving monoclonal antibodies.

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17 May 2022
publication

Structural insights of a highly potent pan-neutralizing SARS-CoV-2 human monoclonal antibody.

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27 Apr 2022
publication

An intranasal lentiviral booster reinforces the waning mRNA vaccine-induced SARS-CoV-2 immunity that it targets to lung mucosa.

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11 Apr 2022
publication

Transient viral exposure drives functionally-coordinated humoral immune responses in HIV-1 post-treatment controllers.

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08 Apr 2022
news

New publication – Epitope convergence of broadly HIV-1 neutralizing IgA and IgG antibody lineages in a viremic controller

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12 Mar 2022
publication

Fusogenicity and neutralization sensitivity of the SARS-CoV-2 Delta sublineage AY.4.2.

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07 Mar 2022
publication

Epitope convergence of broadly HIV-1 neutralizing IgA and IgG antibody lineages in a viremic controller.

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02 Feb 2022
publication

Advances in human monoclonal antibody therapy for HBV infection.

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02 Feb 2022
publication

Broadly neutralizing anti-HIV-1 antibodies tether viral particles at the surface of infected cells.

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01 Feb 2022
publication

Considerable escape of SARS-CoV-2 Omicron to antibody neutralization.

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15 Dec 2021
publication

SARS-CoV-2 Alpha, Beta, and Delta variants display enhanced Spike-mediated syncytia formation.

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22 Oct 2021
publication

NK-B cell cross talk induces CXCR5 expression on natural killer cells.

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13 Oct 2021
event

Groupe de Réflexion SIDA (GRS) meeting: “The cytoskeleton and viruses”

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17 Sep 2021
publication

Sex Differences in the Evolution of Neutralizing Antibodies to Severe Acute Respiratory Syndrome Coronavirus 2.

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01 Sep 2021
publication

Distinct systemic and mucosal immune responses during acute SARS-CoV-2 infection.

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18 Aug 2021
publication

Bystander CD4 T-cell death is inhibited by broadly neutralizing anti-HIV antibodies only at levels blocking cell-to-cell viral transmission.

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14 Aug 2021
publication

A monocyte/dendritic cell molecular signature of SARS-CoV-2 related multisystem inflammatory syndrome in children (MIS-C) with severe myocarditis.

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08 Jul 2021
publication

Reduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization.

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11 Jun 2021
news

COVID-19: sensitivity of the Indian variant (B.1.617.2) to monoclonal antibodies and sera from convalescent and vaccinated individuals

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18 May 2021
publication

Asymptomatic and symptomatic SARS-CoV-2 infections elicit polyfunctional antibodies.

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01 May 2021
publication

Sensitivity of infectious SARS-CoV-2 B.1.1.7 and B.1.351 variants to neutralizing antibodies.

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19 Apr 2021
publication

Mechanisms of HIV-1 evasion to the antiviral activity of chemokine CXCL12 indicate potential links with pathogenesis.

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18 Apr 2021
project

Antibody memory B-cell response to Chikungunya virus

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18 Apr 2021
project

Humoral immunity in HIV-1 post-treatment controllers

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18 Apr 2021
project

Humoral immune response & immunotherapy in HBV infection

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18 Apr 2021
project

Humoral immunity & human monoclonal antibodies against SARS-CoV-2

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01 Jan 2021
publication

CD32+CD4+ T Cells Sharing B Cell Properties Increase With Simian Immunodeficiency Virus Replication in Lymphoid Tissues.

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16 Dec 2020
publication

Intranasal vaccination with a lentiviral vector protects against SARS-CoV-2 in preclinical animal models.

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01 Dec 2020
publication

Syncytia formation by SARS-CoV-2-infected cells.

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30 Nov 2020
publication

TLR-9 agonist and CD40-targeting vaccination induces HIV-1 envelope-specific B cells with a diversified immunoglobulin repertoire in humanized mice.

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20 Oct 2020
publication

Antibody Neutralization of HIV-1 Crossing the Blood-Brain Barrier.

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08 Oct 2020
news

Potent human broadly neutralizing antibodies to hepatitis B virus from natural controllers

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02 Sep 2020
publication

A comparison of four serological assays for detecting anti–SARS-CoV-2 antibodies in human serum samples from different populations

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14 Aug 2020
publication

Binding mechanisms of therapeutic antibodies to human CD20.

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06 Aug 2020
publication

Easy pan-detection of human IgA immunoglobulins.

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30 Jun 2020
publication

Broadly neutralizing antibodies potently inhibit cell-to-cell transmission of semen leukocyte-derived SHIV162P3.

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24 Jun 2020
publication

Potent human broadly neutralizing antibodies to hepatitis B virus from natural controllers.

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10 Jun 2020
publication

MARVellous Sidekick Antibodies.

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28 Feb 2020
publication

Flow Cytometry Analysis of HIV-1 Env Conformations at the Surface of Infected Cells and Virions: Role of Nef, CD4, and SERINC5.

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05 Feb 2020
publication

Anti-HIV-1 antibodies trigger non-lytic complement deposition on infected cells.

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06 Jan 2020
publication

[CRISPR-Cas9 editing of HIV-1 neutralizing human B cells]

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04 Jul 2019
publication

TLR9 Signaling in HCV-Associated Atypical Memory B Cells Triggers Th1 and Rheumatoid Factor Autoantibody Responses

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10 May 2019
event

Groupe de Réflexion SIDA (GRS) meeting: “Mechanisms of HIV antigen presentation”

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09 Apr 2019
publication

HIV-1 Envelope Recognition by Polyreactive and Cross-Reactive Intestinal B Cells

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08 Apr 2019
event

Groupe de Reflexion SIDA (GRS) seminar: “Determinants of HIV-1 broadly neutralizing antibody induction”

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04 Mar 2019
event

Groupe de Réflexion SIDA (GRS) meeting: “Mechanisms of restriction of viral entry”

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31 Jan 2019
project

Archive of the Group for AIDS Research

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21 Nov 2018
event

Groupe de Reflexion SIDA (GRS) seminar: “Tissue-like 3D environment shape modes of HIV-spread”

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18 Sep 2018
event

Groupe de Réflexion SIDA (GRS) seminar: “Defining Correlates of Immunology using Systems Serology”

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01 Aug 2018
publication

A human immune system mouse model with robust lymph node development.

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29 May 2018
publication

Conformational Plasticity in Broadly Neutralizing HIV-1 Antibodies Triggers Polyreactivity

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22 May 2018
event

Groupe de Réflexion SIDA (GRS) meeting: “Humanized mice models for HIV studies”

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09 Apr 2018
publication

Early Antiretroviral Therapy Preserves Functional Follicular Helper T and HIV-Specific B Cells in the Gut Mucosa of HIV-1-Infected Individuals

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27 Feb 2018
event

GRS (Groupe de Réflexion SIDA) meeting: “Immune reconstitution in HIV infection”

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02 Feb 2018
event

Groupe de Réflexion SIDA (GRS) meeting: “Metabolism and HIV”

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30 Nov 2017
publication

Humanized mouse models to study pathophysiology and treatment of HIV infection.

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29 Nov 2017
publication

Genetically intact but functionally impaired HIV-1 Env glycoproteins in the T-cell reservoir

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31 Oct 2017
event

Groupe de Réflexion SIDA (GRS) meeting: “HIV vaccination strategies”

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19 Jun 2017
publication

What Are the Primary Limitations in B-Cell Affinity Maturation, and How Much Affinity Maturation Can We Drive with Vaccination? Lessons from the Antibody Response to HIV-1

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19 Jun 2017
publication

Impact of Antigen Density on the Binding Mechanism of IgG Antibodies

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31 May 2017
publication

HIV-Specific B Cell Frequency Correlates with Neutralization Breadth in Patients Naturally Controlling HIV-Infection

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18 Apr 2017
publication

Hunting Down the HIV-1 Reservoir: A Starring Role for Antibodies?

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06 Apr 2017
event

GRS (Groupe de Reflexion SIDA) meeting: “Residual risk of HIV sexual transmission”

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15 Mar 2017
event

Patrick Wilson seminar

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15 Feb 2017
event

Bernardo Reina San Martin seminar

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25 Jan 2017
publication

Lack of ADCC Breadth of Human Nonneutralizing Anti-HIV-1 Antibodies

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16 Jan 2017
publication

Antibody 10-1074 suppresses viremia in HIV-1-infected individuals

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14 Dec 2016
publication

Broadly neutralizing antibodies suppress post-transcytosis HIV-1 infectivity

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12 Sep 2016
publication

[Antibodies that kill HIV-1-infected cells]

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29 Jul 2016
publication

Scarcity of autoreactive human blood IgA(+) memory B cells

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03 Mar 2016
news

Antibodies capable of eliminating HIV-infected cells

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03 Mar 2016
publication

Elimination of HIV-1-infected cells by broadly neutralizing antibodies

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01 Mar 2016
publication

V1/V2 Neutralizing Epitope is Conserved in Divergent Non-M Groups of HIV-1

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12 Feb 2016
project

Group for AIDS Research

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07 Sep 2015
project

Intestinal and IgA B-cell responses to HIV-1

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07 Sep 2015
project

Clonal B cells in HCV-induced cryoglobulinemia vasculitis

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29 Jul 2015
project

Antiviral properties of broadly neutralizing HIV-1 antibodies

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29 Jul 2015
project

ERC-2013-StG HumAntiViruses

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11 Jul 2015
publication

Tailored immunogens for rationally designed antibody-based HIV-1 vaccines

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11 May 2015
team

Humoral Immunology

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22 Apr 2015
publication

Efficient generation of human IgA monoclonal antibodies

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21 Apr 2015
publication

Neutralization properties of simian immunodeficiency viruses infecting chimpanzees and gorillas

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18 Feb 2015
publication

AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges

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07 Feb 2015
publication

Amplification of highly mutated human Ig lambda light chains from an HIV-1 infected patient

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12 Dec 2014
publication

HIV antibodies. Antigen modification regulates competition of broad and narrow neutralizing HIV antibodies

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17 Sep 2014
publication

Drift of the HIV-1 envelope glycoprotein gp120 toward increased neutralization resistance over the course of the epidemic: a comprehensive study using the most potent and broadly neutralizing monoclonal antibodies

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16 Sep 2014
publication

Antibody B cell responses in HIV-1 infection

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25 Aug 2014
publication

Passive transfer of modest titers of potent and broadly neutralizing anti-HIV monoclonal antibodies block SHIV infection in macaques

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13 Jun 2014
publication

[HIV-1 cell-to-cell transmission and broadly neutralizing antibodies]

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25 Nov 2013
publication

Broadly neutralizing antibodies that inhibit HIV-1 cell to cell transmission

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30 Oct 2013
publication

Antibody-mediated immunotherapy of macaques chronically infected with SHIV suppresses viraemia

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16 Sep 2013
publication

HIV-1 suppression and durable control by combining single broadly neutralizing antibodies and antiretroviral drugs in humanized mice

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13 Sep 2013
publication

Antibodies in HIV-1 vaccine development and therapy

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03 Apr 2013
publication

HIV: Roadmaps to a vaccine

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28 Mar 2013
publication

Somatic mutations of the immunoglobulin framework are generally required for broad and potent HIV-1 neutralization

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30 Oct 2012
publication

Complex-type N-glycan recognition by potent broadly neutralizing HIV antibodies

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24 Oct 2012
publication

HIV therapy by a combination of broadly neutralizing antibodies in humanized mice

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23 Jul 2012
publication

Broad neutralization by a combination of antibodies recognizing the CD4 binding site and a new conformational epitope on the HIV-1 envelope protein

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30 Apr 2012
publication

Dll4-Notch signaling in Flt3-independent dendritic cell development and autoimmunity in mice

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04 Jan 2012
publication

Enhanced HIV-1 neutralization by antibody heteroligation

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02 Nov 2011
publication

Polyreactive antibodies in adaptive immune responses to viruses

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24 Oct 2011
publication

Differential regulation of self-reactivity discriminates between IgG+ human circulating memory B cells and bone marrow plasma cells

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08 Sep 2011
publication

Memory B cell antibodies to HIV-1 gp140 cloned from individuals infected with clade A and B viruses

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14 Jul 2011
publication

Sequence and structural convergence of broad and potent HIV antibodies that mimic CD4 binding

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30 Sep 2010
publication

Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligation

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02 Aug 2010
publication

Human anti-HIV-neutralizing antibodies frequently target a conserved epitope essential for viral fitness

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10 Mar 2010
publication

Anti-gp41 antibodies cloned from HIV-infected patients with broadly neutralizing serologic activity

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10 Aug 2009
publication

Feedback control of regulatory T cell homeostasis by dendritic cells in vivo

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01 May 2009
publication

ELISA testing of anti-desmoglein 1 and 3 antibodies in the management of pemphigus

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15 Mar 2009
publication

Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals

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25 Dec 2008
publication

A method for identification of HIV gp140 binding memory B cells in human blood

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14 Sep 2008
publication

Detection and characterization of anti-envoplakin linker autoantibodies in paraneoplastic pemphigus using specific bead-based assay

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19 Jun 2008
publication

B-cell depletion immunotherapy in pemphigus: effects on cellular and humoral immune responses

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10 Mar 2008
publication

Expression of pemphigus-autoantigen desmoglein 1 in human thymus

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01 Aug 2007
publication

A single cycle of rituximab for the treatment of severe pemphigus

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01 Nov 2006
publication

Immunogenetics of pemphigus: an update

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01 Nov 2006
publication

A truncated alternative spliced isoform of human desmoglein 1 contains a specific T cell epitope binding to the pemphigus foliaceus-associated HLA class II DRbeta1*0102 molecule

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01 Sep 2006
publication

Proteomic analysis of the autoantibody response following immunization with a single autoantigen

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01 Jun 2005
publication

Genetic factors in pemphigus

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01 Mar 2005
publication

[Molecular advances in pathogenesis of autoimmune blistering skin diseases]

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01 Jul 2004
publication

Anti-desmoglein 1 antibodies in Tunisian healthy subjects: arguments for the role of environmental factors in the occurrence of Tunisian pemphigus foliaceus

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01 Feb 2003
publication

Paraneoplastic pemphigus is associated with the DRB1*03 allele

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