Timeline
Hugo Mouquet
Head of Structure
11 Jan 2024
publication
Early antiretroviral therapy favors post-treatment SIV control associated with the expansion of enhanced memory CD8+ T-cells.
Read more05 Jan 2024
event
Group de Reflexion SIDA (GRS) seminar: “New insights in the regulation of HIV expression and latency”
Read more13 Dec 2023
02 Nov 2023
publication
SARS-CoV-2 viral persistence in lung alveolar macrophages is controlled by IFN-γ and NK cells.
Read more25 Oct 2023
10 Oct 2023
10 Oct 2023
publication
HIV-1 treatment timing shapes the human intestinal memory B-cell repertoire to commensal bacteria.
Read more06 Oct 2023
publication
Mucosal application of the broadly neutralizing antibody 10-1074 protects macaques from cell-associated SHIV vaginal exposure.
Read more24 Aug 2023
news
New publication – Anti-V1/V3-glycan broadly HIV-1 neutralizing antibodies in a post-treatment controller
Read more06 Jul 2023
publication
Anti-V1/V3-glycan broadly HIV-1 neutralizing antibodies in a post-treatment controller.
Read more15 Mar 2023
project
CoVariant – Comprendre les déterminants de l’immunité muqueuse et optimiser le diagnostic de l’infection aux variants du SARS-CoV-2
Read more14 Feb 2023
publication
Resistance of Omicron subvariants BA.2.75.2, BA.4.6, and BQ.1.1 to neutralizing antibodies.
Read more03 Feb 2023
publication
Tocilizumab treated convalescent COVID-19 patients retain the cross-neutralization potential against SARS-CoV-2 variants.
Read more21 Dec 2022
publication
Full-Lung Prophylaxis against SARS-CoV-2 by One-Shot or Booster Intranasal Lentiviral Vaccination in Syrian Golden Hamsters.
Read more21 Dec 2022
publication
Full-Lung Prophylaxis against SARS-CoV-2 by One-Shot or Booster Intranasal Lentiviral Vaccination in Syrian Golden Hamsters
Read more17 Nov 2022
publication
Longitudinal analysis of serum neutralization of SARS-CoV-2 Omicron BA.2, BA.4, and BA.5 in patients receiving monoclonal antibodies.
Read more02 Nov 2022
event
Groupe de Reflexion SIDA (GRS) meeting: “Role of membraneless organelles in viral replication”
Read more01 Nov 2022
publication
Evolutionary trajectory of receptor binding specificity and promiscuity of the spike protein of SARS-CoV-2.
Read more19 Sep 2022
publication
The Spike-Stabilizing D614G Mutation Interacts with S1/S2 Cleavage Site Mutations To Promote the Infectious Potential of SARS-CoV-2 Variants.
Read more27 Aug 2022
21 Jul 2022
event
Groupe de Reflexion SIDA (GRS) seminar: “Functional and structural studies of the T cell response against two major human viruses: HIV-1 and SARS-CoV-2”
Read more07 Jul 2022
publication
NK cell spatial dynamics and IgA responses in gut-associated lymphoid tissues during SIV infections.
Read more04 Jul 2022
publication
Potent human broadly SARS-CoV-2-neutralizing IgA and IgG antibodies effective against Omicron BA.1 and BA.2.
Read more28 Jun 2022
publication
SHLD1 is dispensable for 53BP1-dependent V(D)J recombination but critical for productive class switch recombination.
Read more17 Jun 2022
news
New publication – Potent Human Broadly SARS-CoV-2 Neutralizing IgA and IgG Antibodies Effective Against Omicron BA.1 and BA.2
Read more01 Jun 2022
publication
Serum neutralization of SARS-CoV-2 Omicron sublineages BA.1 and BA.2 in patients receiving monoclonal antibodies.
Read more17 May 2022
publication
Structural insights of a highly potent pan-neutralizing SARS-CoV-2 human monoclonal antibody.
Read more27 Apr 2022
publication
An intranasal lentiviral booster reinforces the waning mRNA vaccine-induced SARS-CoV-2 immunity that it targets to lung mucosa.
Read more11 Apr 2022
publication
Transient viral exposure drives functionally-coordinated humoral immune responses in HIV-1 post-treatment controllers.
Read more08 Apr 2022
news
New publication – Epitope convergence of broadly HIV-1 neutralizing IgA and IgG antibody lineages in a viremic controller
Read more12 Mar 2022
publication
Fusogenicity and neutralization sensitivity of the SARS-CoV-2 Delta sublineage AY.4.2.
Read more07 Mar 2022
publication
Epitope convergence of broadly HIV-1 neutralizing IgA and IgG antibody lineages in a viremic controller.
Read more02 Feb 2022
02 Feb 2022
publication
Broadly neutralizing anti-HIV-1 antibodies tether viral particles at the surface of infected cells.
Read more01 Feb 2022
15 Dec 2021
publication
SARS-CoV-2 Alpha, Beta, and Delta variants display enhanced Spike-mediated syncytia formation.
Read more22 Oct 2021
13 Oct 2021
17 Sep 2021
publication
Sex Differences in the Evolution of Neutralizing Antibodies to Severe Acute Respiratory Syndrome Coronavirus 2.
Read more01 Sep 2021
publication
Distinct systemic and mucosal immune responses during acute SARS-CoV-2 infection.
Read more18 Aug 2021
publication
Bystander CD4 T-cell death is inhibited by broadly neutralizing anti-HIV antibodies only at levels blocking cell-to-cell viral transmission.
Read more14 Aug 2021
publication
A monocyte/dendritic cell molecular signature of SARS-CoV-2 related multisystem inflammatory syndrome in children (MIS-C) with severe myocarditis.
Read more08 Jul 2021
11 Jun 2021
news
COVID-19: sensitivity of the Indian variant (B.1.617.2) to monoclonal antibodies and sera from convalescent and vaccinated individuals
Read more18 May 2021
publication
Asymptomatic and symptomatic SARS-CoV-2 infections elicit polyfunctional antibodies.
Read more01 May 2021
publication
Sensitivity of infectious SARS-CoV-2 B.1.1.7 and B.1.351 variants to neutralizing antibodies.
Read more19 Apr 2021
publication
Mechanisms of HIV-1 evasion to the antiviral activity of chemokine CXCL12 indicate potential links with pathogenesis.
Read more18 Apr 2021
18 Apr 2021
18 Apr 2021
18 Apr 2021
01 Jan 2021
publication
CD32+CD4+ T Cells Sharing B Cell Properties Increase With Simian Immunodeficiency Virus Replication in Lymphoid Tissues.
Read more16 Dec 2020
publication
Intranasal vaccination with a lentiviral vector protects against SARS-CoV-2 in preclinical animal models.
Read more01 Dec 2020
30 Nov 2020
publication
TLR-9 agonist and CD40-targeting vaccination induces HIV-1 envelope-specific B cells with a diversified immunoglobulin repertoire in humanized mice.
Read more20 Oct 2020
08 Oct 2020
news
Potent human broadly neutralizing antibodies to hepatitis B virus from natural controllers
Read more02 Sep 2020
publication
A comparison of four serological assays for detecting anti–SARS-CoV-2 antibodies in human serum samples from different populations
Read more14 Aug 2020
06 Aug 2020
30 Jun 2020
publication
Broadly neutralizing antibodies potently inhibit cell-to-cell transmission of semen leukocyte-derived SHIV162P3.
Read more24 Jun 2020
publication
Potent human broadly neutralizing antibodies to hepatitis B virus from natural controllers.
Read more10 Jun 2020
28 Feb 2020
publication
Flow Cytometry Analysis of HIV-1 Env Conformations at the Surface of Infected Cells and Virions: Role of Nef, CD4, and SERINC5.
Read more05 Feb 2020
publication
Anti-HIV-1 antibodies trigger non-lytic complement deposition on infected cells.
Read more06 Jan 2020
04 Jul 2019
publication
TLR9 Signaling in HCV-Associated Atypical Memory B Cells Triggers Th1 and Rheumatoid Factor Autoantibody Responses
Read more10 May 2019
09 Apr 2019
publication
HIV-1 Envelope Recognition by Polyreactive and Cross-Reactive Intestinal B Cells
Read more08 Apr 2019
event
Groupe de Reflexion SIDA (GRS) seminar: “Determinants of HIV-1 broadly neutralizing antibody induction”
Read more04 Mar 2019
31 Jan 2019
21 Nov 2018
event
Groupe de Reflexion SIDA (GRS) seminar: “Tissue-like 3D environment shape modes of HIV-spread”
Read more18 Sep 2018
event
Groupe de Réflexion SIDA (GRS) seminar: “Defining Correlates of Immunology using Systems Serology”
Read more01 Aug 2018
29 May 2018
publication
Conformational Plasticity in Broadly Neutralizing HIV-1 Antibodies Triggers Polyreactivity
Read more22 May 2018
09 Apr 2018
publication
Early Antiretroviral Therapy Preserves Functional Follicular Helper T and HIV-Specific B Cells in the Gut Mucosa of HIV-1-Infected Individuals
Read more27 Feb 2018
02 Feb 2018
30 Nov 2017
publication
Humanized mouse models to study pathophysiology and treatment of HIV infection.
Read more29 Nov 2017
publication
Genetically intact but functionally impaired HIV-1 Env glycoproteins in the T-cell reservoir
Read more31 Oct 2017
19 Jun 2017
publication
What Are the Primary Limitations in B-Cell Affinity Maturation, and How Much Affinity Maturation Can We Drive with Vaccination? Lessons from the Antibody Response to HIV-1
Read more19 Jun 2017
31 May 2017
publication
HIV-Specific B Cell Frequency Correlates with Neutralization Breadth in Patients Naturally Controlling HIV-Infection
Read more18 Apr 2017
06 Apr 2017
15 Mar 2017
15 Feb 2017
25 Jan 2017
16 Jan 2017
14 Dec 2016
12 Sep 2016
29 Jul 2016
03 Mar 2016
03 Mar 2016
01 Mar 2016
12 Feb 2016
07 Sep 2015
07 Sep 2015
29 Jul 2015
29 Jul 2015
11 Jul 2015
11 May 2015
22 Apr 2015
21 Apr 2015
publication
Neutralization properties of simian immunodeficiency viruses infecting chimpanzees and gorillas
Read more18 Feb 2015
publication
AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges
Read more07 Feb 2015
publication
Amplification of highly mutated human Ig lambda light chains from an HIV-1 infected patient
Read more12 Dec 2014
publication
HIV antibodies. Antigen modification regulates competition of broad and narrow neutralizing HIV antibodies
Read more17 Sep 2014
publication
Drift of the HIV-1 envelope glycoprotein gp120 toward increased neutralization resistance over the course of the epidemic: a comprehensive study using the most potent and broadly neutralizing monoclonal antibodies
Read more16 Sep 2014
25 Aug 2014
publication
Passive transfer of modest titers of potent and broadly neutralizing anti-HIV monoclonal antibodies block SHIV infection in macaques
Read more13 Jun 2014
25 Nov 2013
30 Oct 2013
publication
Antibody-mediated immunotherapy of macaques chronically infected with SHIV suppresses viraemia
Read more16 Sep 2013
publication
HIV-1 suppression and durable control by combining single broadly neutralizing antibodies and antiretroviral drugs in humanized mice
Read more13 Sep 2013
03 Apr 2013
28 Mar 2013
publication
Somatic mutations of the immunoglobulin framework are generally required for broad and potent HIV-1 neutralization
Read more30 Oct 2012
publication
Complex-type N-glycan recognition by potent broadly neutralizing HIV antibodies
Read more24 Oct 2012
publication
HIV therapy by a combination of broadly neutralizing antibodies in humanized mice
Read more23 Jul 2012
publication
Broad neutralization by a combination of antibodies recognizing the CD4 binding site and a new conformational epitope on the HIV-1 envelope protein
Read more30 Apr 2012
publication
Dll4-Notch signaling in Flt3-independent dendritic cell development and autoimmunity in mice
Read more04 Jan 2012
02 Nov 2011
24 Oct 2011
publication
Differential regulation of self-reactivity discriminates between IgG+ human circulating memory B cells and bone marrow plasma cells
Read more08 Sep 2011
publication
Memory B cell antibodies to HIV-1 gp140 cloned from individuals infected with clade A and B viruses
Read more14 Jul 2011
publication
Sequence and structural convergence of broad and potent HIV antibodies that mimic CD4 binding
Read more30 Sep 2010
publication
Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligation
Read more02 Aug 2010
publication
Human anti-HIV-neutralizing antibodies frequently target a conserved epitope essential for viral fitness
Read more10 Mar 2010
publication
Anti-gp41 antibodies cloned from HIV-infected patients with broadly neutralizing serologic activity
Read more10 Aug 2009
01 May 2009
publication
ELISA testing of anti-desmoglein 1 and 3 antibodies in the management of pemphigus
Read more15 Mar 2009
publication
Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals
Read more25 Dec 2008
publication
A method for identification of HIV gp140 binding memory B cells in human blood
Read more14 Sep 2008
publication
Detection and characterization of anti-envoplakin linker autoantibodies in paraneoplastic pemphigus using specific bead-based assay
Read more19 Jun 2008
publication
B-cell depletion immunotherapy in pemphigus: effects on cellular and humoral immune responses
Read more10 Mar 2008
01 Aug 2007
01 Nov 2006
01 Nov 2006
publication
A truncated alternative spliced isoform of human desmoglein 1 contains a specific T cell epitope binding to the pemphigus foliaceus-associated HLA class II DRbeta1*0102 molecule
Read more01 Sep 2006
publication
Proteomic analysis of the autoantibody response following immunization with a single autoantigen
Read more01 Jun 2005
01 Mar 2005
01 Jul 2004
publication
Anti-desmoglein 1 antibodies in Tunisian healthy subjects: arguments for the role of environmental factors in the occurrence of Tunisian pemphigus foliaceus
Read more01 Feb 2003