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© Olivier Schwartz, Institut Pasteur
Publication : Current opinion in virology

Advances in human monoclonal antibody therapy for HBV infection.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Current opinion in virology - 02 Feb 2022

Beretta M, Mouquet H,

Link to Pubmed [PMID] – 35123237

Link to DOI – S1879-6257(22)00012-810.1016/j.coviro.2022.101205

Curr Opin Virol 2022 Feb; 53(): 101205

HBV neutralizing antibodies target the viral envelope antigens (HBsAg) and confer long-term immune protection in vaccinees and infected humans who seroconvert. They recognize various HBsAg epitopes, and can be armed with Fc-dependent effector functions essential for eliminating infected cells and stimulating adaptive immunity. Hundreds of HBsAg-specific monoclonal antibodies (mAbs) were produced from the early 80’s, but it is only recently that bona fide human anti-HBV mAbs were generated from vaccinees and seroconverters. Neutralizing HBV mAbs have in vivo prophylactic and therapeutic efficacy in animal models, and the capacity to decrease antigenemia and viremia in infected humans. Thus, polyfunctional, potent and broad human HBV neutralizing mAbs offer novel opportunities to develop effective interventions to prevent and treat HBV infection. Here, we summarize recent findings on the humoral immune response to HBV, and explore the potential of human HBV neutralizing mAbs as immunotherapeutics to help achieving a functional cure for HBV.

https://pubmed.ncbi.nlm.nih.gov/35123237