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© Research
Publication : Trends in immunology

Antibody B cell responses in HIV-1 infection

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Trends in immunology - 16 Sep 2014

Mouquet H

Link to Pubmed [PMID] – 25240985

Trends Immunol. 2014 Nov;35(11):549-61

In rare cases, B cells can supply HIV-1-infected individuals with unconventional antibodies equipped to neutralize the wide diversity of viral variants. Innovations in single-cell cloning, high-throughput sequencing, and structural biology methods have enabled the capture and thorough characterization of these exceptionally potent broadly neutralizing antibodies (bNAbs). Here, I review the recent findings in humoral responses to HIV-1, focusing on the interplay between naturally occurring bNAbs and the virus both at systemic and mucosal levels. In this context, I discuss how an improved understanding of bNAb generation may provide invaluable insight into the fundamental mechanisms governing adaptive B cell responses to viruses, and how this knowledge is currently contributing to the development of vaccine and therapeutic strategies against HIV-1.

http://www.ncbi.nlm.nih.gov/pubmed/25240985