Sex Differences in the Evolution of Neutralizing Antibodies to Severe Acute Respiratory Syndrome Coronavirus 2. - Research

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Group Leader
Head of Facility
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The establishment of variant surface glycoprotein monoallelic expression revealed by single-cell RNA-seq of Trypanosoma brucei in the tsetse fly salivary glands.

High-throughput identification of viral termini and packaging mechanisms in virome datasets using PhageTermVirome

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Published in The Journal of infectious diseases - 17 Sep 2021

Grzelak L, Velay A, Madec Y, Gallais F, Staropoli I, Schmidt-Mutter C, Wendling MJ, Meyer N, Planchais C, Rey D, Mouquet H, Reix N, Glady L, Hansmann Y, Bruel T, De Sèze J, Fontanet A, Gonzalez M, Schwartz O, Fafi-Kremer S,

Link to Pubmed [PMID] – 33693749

Link to DOI – 10.1093/infdis/jiab127

J Infect Dis 2021 09; 224(6): 983-988

We measured anti-spike (S), nucleoprotein (N), and neutralizing antibodies in sera from 308 healthcare workers with a positive reverse-transcription quantitative polymerase chain reaction result for severe acute respiratory syndrome coronavirus 2 and with mild disease, collected at 2 timepoints up to 6 months after symptom onset. At month 1, anti-S and -N antibody levels were higher in male participants aged >50 years and participants with a body mass index (BMI) >25 kg/m2. At months 3-6, anti-S and anti-N antibodies were detected in 99% and 59% of individuals, respectively. Anti-S antibodies and neutralizing antibodies declined faster in men than in women, independent of age and BMI, suggesting an association of sex with evolution of the humoral response.

https://pubmed.ncbi.nlm.nih.gov/33693749

Published on: 17 Sep 2021 • Modified on: 19 Apr 2022