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Scientific Fields
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Published in The Journal of infectious diseases - 07 Mar 2021

Grzelak L, Velay A, Madec Y, Gallais F, Staropoli I, Schmidt-Mutter C, Wendling MJ, Meyer N, Planchais C, Rey D, Mouquet H, Reix N, Glady L, Hansmann Y, Bruel T, De Séze J, Fontanet A, Gonzalez M, Schwartz O, Fafi-Kremer S,

Link to Pubmed [PMID] – 33693749

Link to DOI – jiab12710.1093/infdis/jiab127

J Infect Dis 2021 Mar; ():

We measured Anti-Spike (S), Nucleoprotein (N) and neutralizing antibodies (NAbs) in sera from 308 RT-qPCR + healthcare workers with mild disease, collected at two time-points up to 6 months after symptom onset. At Month 1 (M1), anti-S and N antibody levels were higher in males > 50 years or with a body mass index (BMI) > 25. At M3-6, anti-S and anti-N antibodies were detected in 99% and 59% of individuals, respectively. Anti-S antibodies and NAbs declined faster in males than in females, independently of age and BMI, suggesting an association of sex with evolution of the humoral response.

https://pubmed.ncbi.nlm.nih.gov/33693749