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© Research
Publication : Cold Spring Harbor perspectives in biology

What Are the Primary Limitations in B-Cell Affinity Maturation, and How Much Affinity Maturation Can We Drive with Vaccination? Lessons from the Antibody Response to HIV-1

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Cold Spring Harbor perspectives in biology - 19 Jun 2017

Victora GD, Mouquet H

Link to Pubmed [PMID] – 28630079

Cold Spring Harb Perspect Biol 2017 Jun;

Most broadly neutralizing antibodies to HIV-1 have in common an extreme degree of somatic hypermutation (SHM), which correlates with their ability to neutralize multiple viral strains. However, achieving such extreme SHM by immunization remains a challenge. Here, we discuss how antigenic variation during HIV-1 infection may work to exacerbate SHM by permitting multiple iterative cycles of affinity maturation in germinal centers, and speculate on how this could be recapitulated through vaccination.

https://www.ncbi.nlm.nih.gov/pubmed/28630079