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About

Our team is interested in the role of ‘resident’ macrophages during development, homeostasis and tissue repair. Macrophages are professional phagocytic cells that scavenge dead/apoptotic cells, debris, macromolecules and pathogens, and also produce cytokines, both concurring to tissue homeostasis and repair. They belong to the innate immunity arm of the hematopoietic system.

Within the hematopoietic system that produces all blood cells, tissue ‘resident’ macrophages are a lineage of myeloid cells that arise from yolk sac-derived progenitors and that self-maintain in their tissue of residency, independently of adult hematopoietic stem cells (HSC).

Emergence of CX3CR1-GFP macrophages in the E9.5 to E10.5 embryo.
Emergence of CX3CR1-GFP macrophages in the E9.5 to E10.5 embryo.

Resident macrophages from the same lineage, such as liver Kupffer cells, brain microglia, epidermal Langerhans cells, lung alveolar macrophages…, display tissue-specific phenotypes, perform tissue-specific functions and have distinct gene expression profiles. Thus, resident macrophages are a unique system where the respective contributions of ontogeny and environment can be investigated. We will combine methods from the fields of immunology, developmental biology and angiogenesis to understand in vivo the development and lineage-specific function(s) of resident macrophages, thereby opening new venues of research into the interaction between macrophages and endothelial cells during development and in response to tissue damage.

Fetal macrophages in the developing E13.5 skin, heart and interdigital region in Cx3CR1-GFP embryos.
Fetal macrophages in the developing E13.5 skin, heart and interdigital region in Cx3CR1-GFP embryos.

 

 

Former Members

2000
2000
Name
Position
2015
2015
Vytaute Boreikaite
Undergraduate Student
2016
2016
Martin Plaud
Undergraduate Student
2015
2019
Javier Saenz Coronilla
Post-doc
2017
2019
Caroline Kaiser
Graduate Student
2015
2019
Edith Ollivier
Administrative Staff
2016
2020
Lorea Iturri
PhD student
2019
2023
Rebeca Ponce Landete
PhD student
2022
2022
Corentin Guichen
Master Student
2017
2022
Laina Freyer
Post-doc
2017
2023
Kémy Ade
Post-doc
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Transversal Project

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Contact

Phone: +33 (0)1 45 68 85 24 Email: elisa.gomez-perdiguero@pasteur.fr Address 25-28 Rue du Docteur Roux 75015, Paris France