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© Research
Publication : Nature immunology

Constant replenishment from circulating monocytes maintains the macrophage pool in the intestine of adult mice

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Nature immunology - 24 Aug 2014

Bain CC, Bravo-Blas A, Scott CL, Gomez Perdiguero E, Geissmann F, Henri S, Malissen B, Osborne LC, Artis D, Mowat AM

Link to Pubmed [PMID] – 25151491

Nat. Immunol. 2014 Oct;15(10):929-37

The paradigm that macrophages that reside in steady-state tissues are derived from embryonic precursors has never been investigated in the intestine, which contains the largest pool of macrophages. Using fate-mapping models and monocytopenic mice, together with bone marrow chimera and parabiotic models, we found that embryonic precursor cells seeded the intestinal mucosa and demonstrated extensive in situ proliferation during the neonatal period. However, these cells did not persist in the intestine of adult mice. Instead, they were replaced around the time of weaning by the chemokine receptor CCR2-dependent influx of Ly6C(hi) monocytes that differentiated locally into mature, anti-inflammatory macrophages. This process was driven largely by the microbiota and had to be continued throughout adult life to maintain a normal intestinal macrophage pool.

http://www.ncbi.nlm.nih.gov/pubmed/25151491