Born and raised in Madrid (Spain), I moved to Paris to study at the Ecole Normale Supérieure. I earned my PhD in Physiology and Pathophysiology at the Université Pierre et Marie Curie-Paris 6 in 2009. During my doctoral training at the College de France, I investigated the formation and maturation of blood vessels during development and in ischemic diseases. As a postdoctoral fellow, I joined Frederic Geissmann’s lab, in the Centre of Molecular and Cellular Biology of Inflammation (CMCBI, King’s College London, UK), where I studied the development of macrophages. I was recruited as a Group leader in the Development and Stem Cell Biology Department at the Institut Pasteur where I head the G5 laboratory “Macrophages and endothelial cells”.
Ageing & Longevity
According to the WHO, the global percentage of people aged of more than 60 years will double from 11 to 22% between 2000 and 2050. Nowadays most of the elderly die of non-transmissible diseases […]
ERC-2016-StG _ResidentMacroPhage – Development, Maintenance and Functions of Resident Macrophages
Macrophages are professional phagocytic cells that orchestrate homeostatic and innate immune functions, via the scavenging of cells, debris, and pathogens, and the production of cytokines, both concurring to tissue homeostasis and repair. This project […]
Recipient of the Prix Claude Paoletti 2015
Recipient of the FSER young investigator award 2016
2022Erythro-myeloid progenitor origin of Hofbauer cells in the early mouse placenta., Development 2022 Apr; 149(8): .
2021Megakaryocyte production is sustained by direct differentiation from erythromyeloid progenitors in the yolk sac until midgestation., Immunity 2021 May; (): .
2021Yolk sac, but not hematopoietic stem cell-derived progenitors, sustain erythropoiesis throughout murine embryonic life., J Exp Med 2021 04; 218(4): .
2020Functionally distinct resident macrophage subsets differentially shape responses to infection in the bladder., Sci Adv 2020 Nov; 6(48): .
2020Ontogeny of arterial macrophages defines their functions in homeostasis and inflammation., Nat Commun 2020 09; 11(1): 4549.
2020A wave of bipotent T/ILC-restricted progenitors shapes the embryonic thymus microenvironment in a time-dependent manner., Blood 2021 Feb 25; 137(8): 1024-1036.
2017Identification Of Erythromyeloid Progenitors And Their Progeny In The Mouse Embryo By Flow Cytometry, J Vis Exp 2017 Jul;(125).
2017Erythro-myeloid progenitors can differentiate from endothelial cells and modulate embryonic vascular remodeling., Sci Rep 2017 03; 7(): 43817.
2016The Heterogeneity of Ly6C(hi) Monocytes Controls Their Differentiation into iNOS(+) Macrophages or Monocyte-Derived Dendritic Cells, Immunity 2016 Dec;45(6):1205-1218.
2016ANGPTL4-αvβ3 interaction counteracts hypoxia-induced vascular permeability by modulating Src signalling downstream of vascular endothelial growth factor receptor 2, J. Pathol. 2016 Aug;.
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