Born and raised in Madrid (Spain), I moved to Paris to study at the Ecole Normale Supérieure. I earned my PhD in Physiology and Pathophysiology at the Université Pierre et Marie Curie-Paris 6 in 2009. During my doctoral training at the College de France, I investigated the formation and maturation of blood vessels during development and in ischemic diseases. As a postdoctoral fellow, I joined Frederic Geissmann’s lab, in the Centre of Molecular and Cellular Biology of Inflammation (CMCBI, King’s College London, UK), where I studied the development of macrophages. I was recruited as a Group leader in the Development and Stem Cell Biology Department at the Institut Pasteur where I head the G5 laboratory “Macrophages and endothelial cells”.
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Transversal Projects
Projects
CV
Recipient of the Prix Claude Paoletti 2015
Recipient of the FSER young investigator award 2016
Publications
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2021Megakaryocyte production is sustained by direct differentiation from erythromyeloid progenitors in the yolk sac until midgestation., Immunity 2021 May; (): .
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2021Yolk sac, but not hematopoietic stem cell-derived progenitors, sustain erythropoiesis throughout murine embryonic life., J Exp Med 2021 Apr; 218(4): .
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2020Functionally distinct resident macrophage subsets differentially shape responses to infection in the bladder., Sci Adv 2020 Nov; 6(48): .
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2020Ontogeny of arterial macrophages defines their functions in homeostasis and inflammation., Nat Commun 2020 09; 11(1): 4549.
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2020A wave of bipotent T/ILC-restricted progenitors shapes the embryonic thymus microenvironment in a time-dependent manner., Blood 2021 Feb 25; 137(8): 1024-1036.
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2017Identification Of Erythromyeloid Progenitors And Their Progeny In The Mouse Embryo By Flow Cytometry, J Vis Exp 2017 Jul;(125).
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2017Erythro-myeloid progenitors can differentiate from endothelial cells and modulate embryonic vascular remodeling., Sci Rep 2017 03; 7(): 43817.
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2016The Heterogeneity of Ly6C(hi) Monocytes Controls Their Differentiation into iNOS(+) Macrophages or Monocyte-Derived Dendritic Cells, Immunity 2016 Dec;45(6):1205-1218.
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2016ANGPTL4-αvβ3 interaction counteracts hypoxia-induced vascular permeability by modulating Src signalling downstream of vascular endothelial growth factor receptor 2, J. Pathol. 2016 Aug;.
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2016Development and function of tissue resident macrophages in mice, Semin. Immunol. 2015 Dec;27(6):369-78.
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