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Content 2
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
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Scientific Fields
Diseases
Organisms
Applications
Technique
Starting Date
01
Dec 2015
Ending Date
31
Dec 2017
Status
Ongoing
Members
5
Structures
2

About

Mycobacterium abscessus (M. abs) is an emerging pathogen causing lung infections in cystic fibrosis patients. Although the environmental reservoir of M. abs is currently unknown, M. abs possesses a gene pool dedicated to a life at the water-plant interface. Amoebae are an integral part of this environment, especially those of the genus Acanthamoeba. We recently demonstrated that coculture of M. abs within amoebae confers to this mycobacterial strains an increased virulence, observed with our aerosol mouse model of infection (Bakala N’Goma et al., 2015). A complete RNAseq experiment should help us to better understand the underlying mechanisms, by comparing the messenger RNAs produce by M. abs in contact with amoeba or not. We think indeed that the increased infectivity of M. abs in mice is linked to the accumulation of a “virulence” capital acquired during its intra-amoeba life.