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About

Our group gathers psychiatrists, neuroscientists and geneticists to understand the causes of Autism Spectrum Disorders (ASD). We previously identified one synaptic pathway associated with ASD – the NLGN-NRXN-SHANK pathway. This pathway is known for playing a role in synapse formation and the balance of excitation and inhibition within the brain. In parallel, we identified the first mutations within the melatonin pathway, which could contribute to the sleep problems often observed in individuals with ASD. Our results highlight the genetic heterogeneity of ASD, but also point at common pathways that could constitute relevant knowledge for new treatments targeting the clinical symptoms often associated with ASD such as intellectual disabilities or epilepsy. We are currently performing a thorough genomic and clinical profiling of a large number of individuals (> 1000 families with ASD) using high-throughput genotyping/sequencing, biochemistry and brain imaging. In parallel, we are focusing on a set of mutations that we identified in genes related to the synapse (NLGN, SHANK, CNTN) by studying in depth their functional impact at the clinical and neuronal levels. Especially, we are exploring new ways of modulating the observed deficits by using human induced pluripotent stem cells (iPSC) and animal models. Our group is also developing new methods for analyzing whole genome and brain imaging data as well as new paradigms for characterizing mice social and vocal behaviors.

To learn more about Autism Spectrum Disorders, visit our Autism page.

Find great advice from the Child Psychiatry Department of Pr Richard Delorme (Robert-Debré Hospital) on CléPsy.

Our recent contributions

GeneTrek is an online tool (currently in development) that enables users to explore the association of human genes to neuro-developmental disorders. Users can explore their own gene list or curated gene list. Once queried, GeneTrek describes whether the genes are included in known neurodevelopmental disorder gene lists.

Operative list of genes associated with autism and neurodevelopmental disorders based on database review Leblond et al. 2021

Genome-wide analysis of gene dosage in 24,092 individuals estimates that 10,000 genes modulate cognitive ability Huguet et al. 2021

Spontaneous social communication in laboratory mice – placing ultrasonic vocalizations in their behavioral context Ey, De Chaumont & Bourgeron. 2020

figure1Real-time analysis of the behaviour of groups of mice via a depth-sensing camera and machine learning De Chaumont et al. 2019

Autism-associated SHANK3 mutations impair maturation of neuromuscular junctions and striated muscles Lutz et al. 2020

 Systematic detection of divergent brain proteins in human evolution and their roles in cognition Dumas Malesys & Bourgeron 2019

Polygenic architecture of human neuroanatomical diversity Biton et al. 2019

Decreased phenol sulfotransferase activities associated with hyperserotonemia in autism spectrum disorders Pagan et al. 2021

Mass-spectrometry analysis of the human pineal proteome during night and day and in autism Dumas et al. 2021

Interactive Psychometrics for Autism With the Human Dynamic Clamp: Interpersonal Synchrony From Sensorimotor to Sociocognitive Domains Baillin et al. 2020

Both rare and common genetic variants contribute to autism in the Faroe Islands Leblond et al. 2019

Members

Former Members

2000
2000
Name
Position
2009
2013
Oriane Mercati
PhD Student
2009
2015
Guillaume Huguet
Post-doc
2014
2015
Sophie Calderari
Post-doc
2014
2015
Julien Van Gils
Undergraduate Student
2012
2015
Julien Buratti
Research Engineer
2012
2016
Laura Gouder Desjardin
PhD Student
2013
2016
Anna Bonnet
PhD Student
2008
2017
Anne-Marie Le Sourd
Technician
2016
2018
Thomas Kergrohen
Research Engineer
2013
2018
Marion Benabou
PhD Student
2018
2018
Anna Banki
Graduate Student
2013
2018
Coralie Carton
PhD Student
2008
2018
Isabelle Cloëz-Tayarani
Permanent Researcher
2012
2018
Ophélie Foubet
PhD Student
2008
2019
Corinne Baran
Administrative Staff
2008
2019
Hany Goubran-Botros
Research Engineer
2019
2019
Sandrine Fartek
Graduate Student
2015
2019
Allain-Thibeault Ferhat
PhD Student
2016
2019
Oscar Bauer
PhD Student
2018
2020
Amaury Vaysse
Research Engineer
2014
2020
Anita Beggiato
PhD Student
2015
2020
Nicolas Traut
Research Engineer
2009
2020
Élodie Ey
Permanent Researcher
2013
2020
Guillaume Dumas
Permanent Researcher
2016
2020
Yang-Min Kim
PhD Student
2019
2020
Yann Beauxis-Aussalet
Research Engineer
2018
2021
Julien Fumey
Project manager
2020
2021
Thuy-Linh Le
Post-doc
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Affiliated members

Gothenburg 2006 08 30 Pressreleasepicture for free publication. Christopher Gillberg Bild: Magnus Gotander, Bilduppdraget Christopher Gillberg is Professor of Child and Adolescent Psychiatry at the University of Gothenburg, Sweden, since the mid 1980s. He heads the Gillberg Neuropsychiatry Centre. He is also a Chief Physician at the Sahlgrenska University Hospital and one of the world’s most experienced, clinically active, child- and adolescent psychiatrists, with over 40 years of extensive clinical work in treatment of patients and families with complex psychiatric/neurodevelopmental problems. Christopher Gillberg is affiliated to the “Human Genetics and Cognitive Functions” unit of the Institut Pasteur since 2015. We are working together for more than 15 years on understanding the genetic and environmental factors associated with autism. To visit the Gillberg Neuropsychiatry Centre please go to http://gillbergcentre.gu.se/english

NEWS !!  You can download the slides of Christopher Gillberg here: autism-plus-versus-autism-pure-institut-pasteur-sept-2016

Pictures & Media

IMI EU-AIMS project (EN)

Fondation Bettencourt Schueller (FR)

S3 Odéon Sciences, Santé et Société (FR)