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© Christelle Durand
Microscopie d'un neurone. Le marquage jaune montre les synapses.

About

Our group gathers psychiatrists, neuroscientists and geneticists to understand the causes of autism spectrum disorders (ASD). We previously identified one synaptic pathway associated with ASD – the NLGN-NRXN-SHANK pathway. This pathway is known for playing a role in synapse formation and in the balance of excitation and inhibition within the brain. In parallel, we identified the first mutations within the melatonin pathway, which could contribute to the sleep problems observed in individuals with ASD. Our results highlight the genetic heterogeneity of ASD, but also point at common pathways that could constitute relevant targets for new treatments. We are currently performing a thorough genomic and clinical profiling of a large number of individuals (>1000 families with ASD) using high-throughput genotyping/sequencing, biochemistry and brain imaging. In parallel, we are focusing on a set of mutations that we identified in genes related to the synapse (NLGN, SHANK, CNTN) by studying in depth their functional impact at the clinical and neuronal levels. Especially, we are exploring new ways of modulating the observed deficits by using human induced pluripotent stem cells (iPSC) and animal models. Our group is developing new methods for analyzing whole genome and brain imaging data as well as new paradigms for characterizing mouse social and vocal behaviors.

Our recent papers on bioRxiv !

Both rare and common genetic variants contribute to autism in the Faroe Islands
Claire Leblond, Freddy Cliquet, Coralie Carton, Guillaume Huguet, Alexandre Mathieu, Thomas Kergrohen, Julien Buratti, Nathalie Lemière, Laurence Cuisset, Thierry Bienvenu, Anne Boland, Jean-François Deleuze, Tormodur Stora, Rannva Biskupstoe, Jónrit Halling, Guðrið Andorsdóttir, Eva Billstedt, Christopher Gillberg Thomas Bourgeron

Live Mouse Tracker: real-time behavioral analysis of groups of mice
Fabrice de Chaumont, Elodie Ey, Nicolas Torquet, Thibault Lagache, Stephane Dallongeville, Albane Imbert, Thierry Legou, Anne-Marie Le Sourd, Philippe Faure, Thomas Bourgeron, Jean-Christophe Olivo-Marin

 


Experimenting with reproducibility in bioinformatics
Yang-Min Kim, Jean-Baptiste Poline, Guillaume Dumas

 

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Gothenburg 2006 08 30 Pressreleasepicture for free publication. Christopher Gillberg Bild: Magnus Gotander, Bilduppdraget

Christopher Gillberg is Professor of Child and Adolescent Psychiatry at the University of Gothenburg, Sweden, since the mid 1980s. He heads the Gillberg Neuropsychiatry Centre. He is also a Chief Physician at the Sahlgrenska University Hospital and one of the world’s most experienced, clinically active, child- and adolescent psychiatrists, with over 40 years of extensive clinical work in treatment of patients and families with complex psychiatric/neurodevelopmental problems.

Christopher Gillberg is affiliated to the “Human Genetics and Cognitive Functions” unit of the Institut Pasteur since 2015. We are working together for more than 15 years on understanding the genetic and environmental factors associated with autism.

To visit the Gillberg Neuropsychiatry Centre please go to http://gillbergcentre.gu.se/english

NEWS !!  You can download the slides of Christopher Gillberg here: autism-plus-versus-autism-pure-institut-pasteur-sept-2016

Pictures & Media

IMI EU-AIMS project (EN)

Fondation Bettencourt Schueller (FR)

S3 Odéon Sciences, Santé et Société (FR)

Contact

 

Thomas Bourgeron

Institut Pasteur
25 rue du Docteur Roux, 75015, Paris
France

e-mail : thomasb@pasteur.fr (cc. cbaran@pasteur.fr)
Phone : (33) 1 40 61 34 20
Fax : (33) 1 40 61 34 21