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About

COVID-19 Confinement / Lockdown 

De supers conseils du service de pédopsychiatrie du Professeur Richard Delorme à l’Hôpital Robert Debré !

Some really good advices from the child psychiatry Dept of Professor Richard Delorme at Robert Debré Hospital (soon in English and Spanish) !

https://www.pedopsydebre.org/fiches-pratiques

Our group gathers psychiatristsneuroscientists and geneticists to understand the causes of autism. We previously identified one synaptic pathway associated with autism – the NLGN-NRXN-SHANK pathway. This pathway is known for playing a role in synapse formation and the balance of excitation and inhibition within the brain. In parallel, we identified the first mutations within the melatonin pathway, which could contribute to the sleep problems observed in individuals with autism.

Our results highlight the genetic heterogeneity of autism, but also point at common pathways that could constitute relevant knowledge for new treatments targeting the clinical symptoms often associated with autism such as intellectual disabilities or epilepsy. We are currently performing a thorough genomic and clinical profiling of a large number of individuals (> 1000 families with autism) using high-throughput genotyping/sequencing, biochemistry and brain imaging. In parallelwe are focusing on a set of mutations that we identified in genes related to the synapse (NLGN, SHANK, CNTN) by studying in depth their functional impact at the clinical and neuronal levels. Especiallywe are exploring new ways of modulating the observed deficits by using human induced pluripotent stem cells (iPSC) and animal models.

Our group is also developing new methods for analyzing whole genome and brain imaging data as well as new paradigms for characterizing mice social and vocal behaviors.

Our recent papers !

Spontaneous social communication in laboratory mice – placing ultrasonic vocalizations in their behavioral context
Ey et al.

 

Autism-associated SHANK3 mutations impair maturation of neuromuscular junctions and striated muscles

Anne-Kathrin Lutz et al. 

Systematic detection of divergent brain proteins in human evolution and their roles in cognition Guillaume DumasSimon Malesys, Thomas Bourgeron

Polygenic architecture of human neuroanatomical diversity

Anne Biton,Nicolas Traut,Jean-Baptiste PolineBenjamin S. AribisalaMark E. BastinRobin BülowSimon R. CoxIan J. DearyHans J. GrabeSaskia HagenaarsRyota HashimotoSusana Muñoz ManiegaMatthias NauckNatalie A. RoyleAlexander TeumerMaria Valdes HernandezUwe VölkerJoanna M. WardlawKatharina WittfeldAlzheimer’s Disease Neuroimaging Initiative,Thomas Bourgeron,Roberto Toro

figure1

Real-time analysis of the behaviour of groups of mice via a depth-sensing camera and machine learning Fabrice de Chaumont, Elodie Ey, Nicolas Torquet, Thibault Lagache, Stephane Dallongeville, Albane Imbert, Thierry Legou, Anne-Marie Le Sourd, Philippe Faure, Thomas Bourgeron, Jean-Christophe Olivo-Marin

Both rare and common genetic variants contribute to autism in the Faroe Islands
Claire Leblond, Freddy Cliquet, Coralie Carton, Guillaume Huguet, Alexandre Mathieu, Thomas Kergrohen, Julien Buratti, Nathalie Lemière, Laurence Cuisset, Thierry Bienvenu, Anne Boland, Jean-François Deleuze, Tormodur Stora, Rannva Biskupstoe, Jónrit Halling, Guðrið Andorsdóttir, Eva Billstedt, Christopher Gillberg Thomas Bourgeron

Members

Former Members

2000
2000
Name
Position
2009
2013
Oriane Mercati
PhD Student
2009
2015
Guillaume Huguet
Post-doc
2014
2015
Sophie Calderari
Post-doc
2014
2015
Julien Van Gils
Undergraduate Student
2012
2015
Julien Buratti
Research Engineer
2012
2016
Laura Gouder Desjardin
PhD Student
2013
2016
Anna Bonnet
PhD Student
2008
2017
Anne-Marie Le Sourd
Technician
2016
2018
Thomas Kergrohen
Research Engineer
2013
2018
Marion Benabou
PhD Student
2018
2018
Anna Banki
Graduate Student
2013
2018
Coralie Carton
PhD Student
2008
2018
Isabelle Cloëz-Tayarani
Permanent Researcher
2012
2018
Ophélie Foubet
PhD Student
2008
2019
Corinne Baran
Administrative Staff
2008
2019
Hany Goubran-Botros
Research Engineer
2019
2019
Sandrine Fartek
Graduate Student
2015
2019
Allain-Thibeault Ferhat
PhD Student
2016
2019
Oscar Bauer
PhD Student
2018
2020
Amaury Vaysse
Research Engineer
2014
2020
Anita Beggiato
PhD Student
2015
2020
Nicolas Traut
Research Engineer
2009
2020
Élodie Ey
Permanent Researcher
2013
2020
Guillaume Dumas
Permanent Researcher
2016
2020
Yang-Min Kim
PhD Student
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Affiliated members

Gothenburg 2006 08 30 Pressreleasepicture for free publication. Christopher Gillberg Bild: Magnus Gotander, Bilduppdraget Christopher Gillberg is Professor of Child and Adolescent Psychiatry at the University of Gothenburg, Sweden, since the mid 1980s. He heads the Gillberg Neuropsychiatry Centre. He is also a Chief Physician at the Sahlgrenska University Hospital and one of the world’s most experienced, clinically active, child- and adolescent psychiatrists, with over 40 years of extensive clinical work in treatment of patients and families with complex psychiatric/neurodevelopmental problems. Christopher Gillberg is affiliated to the “Human Genetics and Cognitive Functions” unit of the Institut Pasteur since 2015. We are working together for more than 15 years on understanding the genetic and environmental factors associated with autism. To visit the Gillberg Neuropsychiatry Centre please go to http://gillbergcentre.gu.se/english

NEWS !!  You can download the slides of Christopher Gillberg here: autism-plus-versus-autism-pure-institut-pasteur-sept-2016

Pictures & Media

IMI EU-AIMS project (EN)

Fondation Bettencourt Schueller (FR)

S3 Odéon Sciences, Santé et Société (FR)

Contact

Thomas Bourgeron Institut Pasteur 25 rue du Docteur Roux, 75015, Paris France e-mail : thomasb@pasteur.fr (cc. ghfc1@pasteur.fr) Phone : (33) 1 40 61 34 20 Fax : (33) 1 40 61 34 21