My research involves developping innovative and systematic computational approaches to analyze genomics and proteomics data of increasing quantity and quality. My goal is to characterize the mechanisms by which genomes, proteomes and interactomes evolve and how their perturbation can lead to different cellular states. In Prof. Bourgeron’s lab, I study the human protein interaction network to characterize complex genotype-phenotype relationships in the context of autism spectrum disorders. You can find more information on My Research Portal.
(FR) Étude des facteurs génétiques impliqués dans l’autisme et les troubles apparentés (projet “C07/C16”)
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PARIS: Paris Autism Research International Sib-Pair Study
The Paris Autism Research International Sib-pair (PARIS) Study has been launched as a collaborative project by Prof. M. Leboyer (Paris) and Prof. C. Gillberg (Göteborg) in the 2000s. Its main goal is to join […]
Around 1% of children are diagnosed with autism spectrum disorders (ASD), yet there are currently no drugs designed specifically to treat their main symptoms. Working to change this is the IMI-funded EU-AIMS project. The […]
Background on the genetics of ASD
Autism spectrum disorders (ASD) are a heterogeneous group of pervasive neurodevelopmental disorders affecting approximately 1% of the population. The diagnosis of ASD is based on impairments in reciprocal social communication and stereotyped behaviors. Behind […]
Protected: Risk and Resilience in Neuropsychiatry
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Phelan-McDermid Syndrome: from mechanisms to treatments
Our team identified the first mutations in the SHANK3 gene, showing it’s role in autism and Phelan-McDermid Syndrome (PMS). Thanks to a donation from the French Association of Phelan-McDermid Syndrome, we will continue the […]
The serotonin-NAS-melatonin pathway and susceptibility to ASD
Sleep difficulties are a major concern for families with ASD, but are often considered as an epiphenomenon, and therefore do not catch the attention of the medical and scientific community. In 2008, we reported […]
GeneTrek is an online tool that enables users to explore the association of human genes to neurodevelopmental disorders. Users can explore their own gene list or any of the curated gene list. Once queried, […]
2022Genetic Heterogeneity Shapes Brain Connectivity in Psychiatry., Biol Psychiatry 2022 Sep; (): .
2022Genetic correlates of phenotypic heterogeneity in autism., Nat Genet 2022 Sep; 54(9): 1293-1304.
2021Operative list of genes associated with autism and neurodevelopmental disorders based on database review., Mol Cell Neurosci 2021 Jun; 113(): 103623.
2020A reference map of the human binary protein interactome., Nature 2020 Apr; 580(7803): 402-408.
2017Heritability of the melatonin synthesis variability in autism spectrum disorders., Sci Rep 2017 Dec; 7(1): 17746.
2017A framework to identify contributing genes in patients with Phelan-McDermid syndrome., NPJ Genom Med 2017 ; 2(): 32.
2016CNTN6 mutations are risk factors for abnormal auditory sensory perception in autism spectrum disorders, Mol. Psychiatry 2017 04;22(4):625-633.
2016An inter-species protein-protein interaction network across vast evolutionary distance., Mol Syst Biol 2016 Apr; 12(4): 865.
2015Genome-wide replication landscape of Candida glabrata, BMC Biol. 2015 Sep;13:69.
2015Protein domain-level landscape of cancer-type-specific somatic mutations., PLoS Comput Biol 2015 Mar; 11(3): e1004147.
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