Ecole thématique – Bioinformatics of protein-protein interactions for wet lab scientists
Background on the genetics of ASD
Autism spectrum disorders are a heterogeneous group of pervasive neurodevelopmental disorders affecting approximately 1% of the population. The diagnosis of ASD is based on impairments in reciprocal social communication and stereotyped behaviors. Behind the […]
Phelan McDermid Syndrome: from mechanisms to treatments
Phelan-McDermid syndrome (PMS) is a neurodevelopmental disorder with non-specific clinical features. The main symptoms are hypotonia, intellectual disability (ID), absent or delayed speech together with minor dysmorphic features. More than half of the patients […]
The serotonin-NAS-melatonin pathway and susceptibility to ASD
Sleep difficulties are a major concern for families with ASD, but are often considered as an epiphenomenon, and therefore do not catch the attention of the medical and scientific community. In 2008, we reported […]
2017Heritability of the melatonin synthesis variability in autism spectrum disorders, Sci Rep 2017 Dec;7(1):17746.
2017A framework to identify contributing genes in patients with Phelan-McDermid syndrome, NPJ Genom Med 2017;2:32.
2016CNTN6 mutations are risk factors for abnormal auditory sensory perception in autism spectrum disorders, Mol. Psychiatry 2017 Apr;22(4):625-633.
2016An inter-species protein-protein interaction network across vast evolutionary distance, Mol. Syst. Biol. 2016;12(4):865.
2015Genome-wide replication landscape of Candida glabrata, BMC Biol. 2015;13:69.
2015Protein domain-level landscape of cancer-type-specific somatic mutations, PLoS Comput. Biol. 2015 Mar;11(3):e1004147.
2014A proteome-scale map of the human interactome network, Cell 2014 Nov;159(5):1212-26.
2014A chaperome subnetwork safeguards proteostasis in aging and neurodegenerative disease, Cell Rep 2014 Nov;9(3):1135-50.
2014Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage, Genes Dev. 2014 Sep;28(17):1957-75.
2013Exploration of binary virus-host interactions using an infectious protein complementation assay, Mol. Cell Proteomics 2013 Oct;12(10):2845-55.
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