Génétique Humaine et Fonctions Cognitives

We implement and develop data analysis pipelines to process large neuroimaging-genetics datasets, and participate in the analysis of several very large international consortia. We have developed online and offline interactive tools to examine the […]

Human brain anatomy is strikingly diverse and highly inheritable: genetic factors may explain up to 80% of its variability. Genome-wide scans looking for associations between genomic polymorphism and neuroanatomical variability identify, however, just a […]

Autism spectrum disorders are a heterogeneous group of pervasive neurodevelopmental disorders affecting approximately 1% of the population. The diagnosis of ASD is based on impairments in reciprocal social communication and stereotyped behaviors. Behind the […]

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The project SoNeTAA combines human-human and human-machine interactions with electroencephalography (EEG) recording to approach social cognition from a situated and reciprocal standpoint. The project especially focuses on Autism Spectrum Disorders and aims to bridge […]

Recent progress in sequencing and bioinformatics methods have given access to ancient DNA. This project aims at understanding the differential evolutionary pressure on the key proteins implicated in the nervous system, especially those related […]

Phelan-McDermid syndrome (PMS) is a neurodevelopmental disorder with non-specific clinical features. The main symptoms are hypotonia, intellectual disability (ID), absent or delayed speech together with minor dysmorphic features. More than half of the patients […]

To tackle the genetic and phenotypic heterogeneity of ASD, our group is part of several national and international consortia that provide the specific expertise required to explore different facets of ASD. In France, our […]

In order to characterize the mechanisms leading to autism spectrum disorders, we are studying several mouse models. These models are mutated in a gene of interest that has been associated with ASD in genetic […]

Sleep difficulties are a major concern for families with ASD, but are often considered as an epiphenomenon, and therefore do not catch the attention of the medical and scientific community. In 2008, we reported […]

Our group is exploring the human brain using Magnetic Resonance Imaging (MRI) and electroencephalogram (EEG). These approaches are combined with our genetic data in order to better understand the genetic and phenotypic diversity of […]

GRAVITY allows for rapid visualization and analysis of all the exonic variants stored in a database or in a VCF file by mapping them on an interaction network. It is designed as a plugin […]

Patients stratification with Graph-regularized Non-negative Matrix Factorization (GNMF) in Python.

BrainBox (http://brainbox.pasteur.fr) is a web application developed by the Groupe de Neuroanatomie appliquée et théorique de l’Unité de génétique humaine et fonctions cognitives. BrainBox lets you visualise and segment collaboratively any brain MRI dataset available […]

MicroDraw is a web application to visualise and annotate collaboratively high resolution histology data. Annotations are vectorial, and you can use boolean operations to combine, subtract and split regions. You can point MicroDraw to […]

The Brain Catalogue is a collaborative platform for comparative neuroanatomy. Our aim is to celebrate the diversity of the vertebrate brain by making high quality data, open and freely available to everyone. You can […]

BrainSpell is a web platform for the collaborative annotation of the neuroimaging literature. You can use BrainSpell here: http://brainspell.pasteur.fr

This web application allows the exchange of mouse vocalisation recording files. https://mousetube.pasteur.fr/ You can be part of the community by clicking here.

This tool allows you to visualize protein-protein interactions at different developmental periods and in different regions of the human brain : http://ppiviz.pasteur.fr/