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© Pierre Gounon
Entrée de Listeria dans une cellule épithéliale (Grossissement X 10000). Image colorisée.

About

Our Unit investigates the molecular and cellular basis of the infection by Listeria monocytogenes, a model pathogen for the study of the intracellular parasitism. L. monocytogenes is responsible for severe foodborne infections. This bacterium is characterized by its ability to cross three host barriers -the intestinal, blood-brain or feto-placental barriers- and to invade several cell types in which it multiplies. L. monocytogenes moves in the cytosol of infected cells and spreads from cell to cell using an original propelling process; i.e. cell actin polymerization at one pole of the bacteria.

Our present activity focuses on:

  1. the identification and characterization of new non-coding RNAs involved in virulence, as well as new RNA-mediated regulations;
  2. the investigation of new molecular pathways involved in bacterial entry into host cells and cell-to-cell spread;
  3. organelle dynamics during infection;
  4. the systematic analysis of post-translational modifications of host molecules during infection, in particular SUMOylation;
  5. chromatin remodeling upon infection;
  6. the characterization of new bacterial virulence factors identified by post-genomic approaches or by their effect on cellular responses;
  7. in-depth understanding of the intestinal phase of the L. monocytogenes infection by analyzing the impact of commensals on L. monocytogenes growth and the bacterial effect on the intestinal tissue.

In many of these research themes, we try to generalize our findings to other bacterial models.

The “Unité des Interactions Bactéries-Cellules” (UIBC) is associated with Inserm (INSERM U604) and with INRA (INRA USC2020)

 

Former Members

2000
2000
Name
Position
2014
2020
Alice Lebreton
2014
2020
Nicole King
2014
2020
Nina Sesto
2014
2020
Hélène Bierne
Permanent Researcher
2014
2020
Ascel Samba-Louaka
2014
2020
Amy Palmer
2014
2020
Alexander Eskandarian
2014
2020
Goran Lakisic
2014
2020
Christel Archambaud
2014
2020
Hana Jilani-Salah
2014
2020
Serge Mostowy
2014
2020
Laurent Dortet
2014
2020
Zongfu Wu
2014
2020
Matteo Bonazzi
2014
2020
Nicolas Personnic
2014
2020
Serawit Bruck
2014
2020
Damien Balestrino
2014
2020
Alejandro Toledo-Arana
2014
2020
Esteban Veiga
2014
2020
Christophe Sabet
2014
2020
Marc Lecuit
Head of Structure
2014
2020
Olivier Disson
Permanent Researcher
2014
2020
Nadia Khelef
2014
2020
Francis Repoila
2014
2020
Pierre Mandin
2014
2020
Stéphanie Dupuis
2014
2020
Juan Martinez
2014
2020
Stéphanie Seveau
2014
2020
Didier Cabanes
2014
2020
Sandra Sousa
2014
2020
Eugénie Huillet
2014
2020
Jorgen Johansson
2014
2020
Jeffrey Mellin
Post-doc
2014
2020
Christophe Becavin
Research Engineer
2014
2020
Mélanie Hamon
Head of Structure
2014
2020
Francis Impens
Post-doc
2014
2020
Théodore Grenier
Undergraduate Student
2014
2020
Kattia Nunez Montero
Graduate Student
2014
2020
Barbara Villoing
Undergraduate Student
2014
2020
Natasha Kafai
Undergraduate Student
2014
2020
Andreas Kühbacher
PhD Student
2014
2020
Yulia Redko Hamel
Post-doc
2014
2020
Steven Rolland
Undergraduate Student
2014
2020
Mikael Koutero
PhD Student
2014
2020
Véronique Villiers
Technician
2014
2020
Julien Karim Malet
PhD Student
2014
2020
Juan Jose Quereda Torres
Post-doc
2014
2020
Javier Pizarro-Cerda
Head of Structure
2014
2020
Lilliana Radoshevich
Post-doc
2014
2020
Daryl David
Post-doc
2014
2020
Jorge Pereira
PhD Student
2014
2020
Laurence Maranghi
Technician
2014
2020
Edith Gouin
Research Engineer
2014
2020
Giulia Spano
Undergraduate Student
2014
2020
Olivier Dussurget
Permanent Researcher
2014
2020
Fabrizia Stavru
Permanent Researcher
2014
2020
Melodie Duval
Post-doc
2014
2020
Matthew Eldridge
Post-doc
2014
2020
Nathalie Rolhion
Post-doc
2014
2020
Zerrin Uzum
Post-doc
2014
2020
Jazmin Meza Torres
PhD Student
2014
2020
Anna Spier
PhD Student
2014
2020
Marie-Anne Nahori
Research Engineer
2014
2020
To Nam Tham
Research Engineer
2014
2020
Stevens Robertin
Undergraduate Student
2014
2020
Youssouf Boina Boina
2014
2020
Alessandro Pagliuso
Post-doc
2014
2020
Sabrina Jabs
Post-doc
2014
2020
Filipe Carvalho
Post-doc

Projects

Transversal Project

Fundings

Partners

Publications

Download

Pictures & Media

Listeria monocytogenes, a unique model in infection biology

Youtube links: English | French


Lectures

iBiology Research Talks: “The Bacterial Pathogen Listeria monocytogenes” (Pascale Cossart)


American Society for Microbiology – Virtual Lectures:Listeria monocytogenes: A multifaceted model… and a reference by Pascale Cossart, PhD


Interviews (video & podcast)

Les entretiens de médecine/sciences: Pascale Cossart (Microbiologist, Institut Pasteur Paris)

“Pascale Cossart: à la chasse aux bactéries”La marche des sciences (France Culture), 25 February 2016 “La nouvelle microbiologie”La tête au carré (France Inter), 9 June 2016 “Cher Alan Turing”La marche des sciences (France Culture), 23 June 2016 (starts at minute 48)

Contact

Bacteria-cell interactions Unit – INSERM U604 – INRA USC2020 Department of Cell biology and Infection 25 rue du Docteur Roux -75724 PARIS Cedex 15-France. Tel : + 33 (1) 45 68 88 41 (secretary: + 33 (1) 40 61 30 32) Fax : + 33 (1) 86 46 79 49 E-mail : pascale.cossart@pasteur.fr