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  • Director of Center
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Scientific Fields
Diseases
Organisms
Applications
Technique
Starting Date
01
Jul 2015
Ending Date
29
Jun 2018
Status
Ongoing
Members
7
Structures
4

About

GRAVITY allows for rapid visualization and analysis of all the exonic variants stored in a database or in a VCF file by mapping them on an interaction network. It is designed as a plugin for the Cytoscape platform (http://cytoscape.org).

This data analysis can either be specifically oriented towards knowns pathways involved in ASD (e.g. glutamatergic synapse pathway) or known set of genes from specialized databanks (e.g. SFARI), either be exploratory by looking at the whole exome.

Screenshot of GRAVITY
Screenshot of GRAVITY where we can see all the mutations carried by the patient 1005201323-NICE-BER on the SFARI genes. The selected gene, SHANK3, carries a de novo mutation for which the details are visible on the right side.

It can help with the regular trio analysis (a proband with his parents) such as finding de novo mutations, or recessive mutations, but also allows to visualize the mutation burden on a gene, or a group of gene, for an individual. This is done by comparing his number of mutation to the other patients or to controls.

Additionally we can quickly find back in a cohort all the individuals carrying mutations in a given gene or pathway, making it easier for the clinician to build and validate hypothesis.

The development of this tool is still in progress.

Documentation and tool available at http://gravity.pasteur.fr.

Fundings