Search anything and hit enter
  • Teams
  • Members
  • Projects
  • Events
  • Calls
  • Jobs
  • publications
  • Software
  • Tools
  • Network
  • Equipment

A little guide for advanced search:

  • Tip 1. You can use quotes "" to search for an exact expression.
    Example: "cell division"
  • Tip 2. You can use + symbol to restrict results containing all words.
    Example: +cell +stem
  • Tip 3. You can use + and - symbols to force inclusion or exclusion of specific words.
    Example: +cell -stem
e.g. searching for members in projects tagged cancer
Search for
Count
IN
OUT
Content 1
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Content 2
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Search
Go back
Scroll to top
Share
Scientific Fields
Diseases
Organisms
Applications
Technique
Starting Date
01
Jul 2015
Ending Date
29
Jun 2018
Status
Ongoing
Members
8
Structures
4

About

Gravity (for Gene inteRaction Analysis of Variants in Individuals: a Tool for You) provides a visualisation of genetic data from SNP array, whole genome and whole exome data in the context of protein-protein interactions. In addition, it allows the user to dynamically filter on sequencing quality or allelic frequency, or to focus on specific pathways of interest. The tool integrates analyses of mutation pattern across full cohorts of patients and their relatives, identifying multiple hits in individuals and providing a precise characterisation of the variants.

Gravity takes as an input a Gemini database generated from a variant calling file containing all the variants identified in a cohort. As an output, the visualisation of the variants found in an individual or in a family includes the network representation, the full annotation of each variant, i.e. frequency, deleteriousness and inheritance patterns, as well as cohort details on other carrying individuals. The network representation, as well as the gene annotation and sequencing parameters, can be exported through Cytoscape functions or tab-separated files.

Gravity helps in the interpretation of the combined effect of multiple mutations within different pathways of interest in the patients, setting the stage for better patient stratification and potentially more precise and personalised therapeutic strategies.

Documentation and tool available at http://gravity.pasteur.fr.

 

Screenshot of GRAVITY
Screenshot of GRAVITY where we can see all the mutations carried by the patient 1005201323-NICE-BER on the SFARI genes. The selected gene, SHANK3, carries a de novo mutation for which the details are visible on the right side.

Fundings