Mariette Matondo • Research - Institut Pasteur

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member
team
department
center
program_project
nrc
whocc
project
software
tool
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Administrative Staff
Assistant Professor
Associate Professor
Clinical Research Assistant
Full Professor
Graduate Student
Lab assistant
Non-permanent Researcher
Permanent Researcher
Pharmacist
PhD Student
Physician
Post-doc
Project Manager
Research Associate
Research Engineer
Retired scientist
Technician
Undergraduate Student
Veterinary
Visiting Scientist

Appointments

Deputy Director of Center
Deputy Director of Department
Deputy Director of National Reference Center
Deputy Head of Facility
Director of Center
Director of Department
Director of Institute
Director of National Reference Center
Group Leader
Head of Facility
Head of Operations
Head of Structure
Honorary President of the Departement
Labex Coordinator

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30 Publications

About

I have been the manager of the Pasteur Proteomics facility since September 2013. I am responsible for the operations of the proteomics platform and the coordination of the different ongoing projects. I did my PhD research in the group of Dr. Bernard Monsarrat and Dr. Odile Schiltz at the Institute of Pharmacology and Structural Biology (IPBS, University Paul Sabatier, UPS, also known as Toulouse III, France). As part of my PhD work, I used high-resolution mass spectrometers, including the LTQ-Orbitrap, in combination with various quantitative proteomic approaches. My focus was on stable isotope labelling strategies (SILAC and ICAT) to study the proteasome inhibitor effect in acute myeloid leukaemia cells. I then moved to the Institute of Molecular Systems Biology in Eidgenössische Technische Hochschule (ETH Zürich) as a post-doctoral fellow in the group of Professor Ruedi Aebersold. I worked on multiple projects using mass spectrometry to assess changes in protein abundance and posttranslational modifications, e.g., ubiquitin, SUMO, and chlorination of proteins using discovery-driven and targeted mass spectrometry. During this time, I utilised the new data independent acquisition mode developed in Ruedi Aebersold Lab, namely SWATH-MS.

Projects

Landscape of protein ubiquitylation during infection by CNF1-producing uropathogenic E. coli

Emmanuel Lemichez (PI)

CNF1 is a toxin that catalyzes the permanent activation of host RhoA, Rac1 and Cdc42 small GTPases by selective deamidation of a glutamine residue into a glutamic acid. This 1 dalton post-translational modification can […]

Role of tubulin glutamylation in flagellum construction (TUBGLUFLA)

Philippe Bastin (PI)

Cilia and flagella are essential eukaryotic organelles composed of an evolutionary conserved structure of 9 doublet microtubules that are similar but not equivalent. We propose that a tubulin post-translational modification called glutamylation could act […]

SUPERCPLX

Marco Bellinzoni (PI)

Acyl-CoAs are the major metabolic carriers of carbon in living organisms. The most conserved ways to their synthesis include the oxidative decarboxylation of α-ketoacids carried out by three distinct enzymatic machineries: the pyruvate dehydrogenase […]

PTR 539 – A multilevel systems approach to elucidate the host-Leishmania interactome and to identify host targets for anti-leishmanial drug discovery

Joo Hwan No (PI)

Our PTR project investigates at the complex interface between the intracellular pathogen Leishmania and its macrophage host cell. We will apply systems-wide analyses to elucidate the molecular mechanisms underlying the reciprocal metabolic relationship between […]

Post translational modifications (PTM)

Mariette Matondo (PI)

Post translational modifications (PTMs) are known to play pivotal roles in cellular physiology and disease, but only a few of the over 300 currently known modifications are extensively investigated in proteomic studies. The most […]

Interaction Proteomics

Mariette Matondo (PI)

Affinity Purification Mass Spectrometry (AP-MS) is the method of choice to study protein-protein interactions (PPI) and complexes under near physiological conditions. A protein of interest – the bait – is purified by either a […]

Quantitative Proteomics

Mariette Matondo (PI)

Within cells, proteins are the real effectors of all activities. The expression of certain proteins changes upon cell stimulation or stress (with virus, inhibitors or bacteria), or when cells differentiate or turn into a […]

Publications

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Published on: 07 Feb 2015 • Modified on: 19 Dec 2017