Timeline
Darragh Duffy
Labex Coordinator
01 Mar 2025
publication
Autoinflammatory encephalopathy due to PTPN1 haploinsufficiency: a case series.
Read more01 Jan 2025
publication
Comment on: Inflammatory plasma protein levels are elevated years before sarcoidosis diagnosis: a nested case-control study in Sweden.
Read more01 Jan 2025
publication
Efficacy of Ruxolitinib in Severe Pediatric Intra-Alveolar Hemorrhages Unrelated to COPA Mutations.
Read more01 Jan 2025
publication
Ultrasensitive interferons quantification reveals different cytokine profile secretion in inflammatory myopathies and can serve as biomarkers of activity in dermatomyositis.
Read more12 Nov 2024
publication
Increased mortality in diffuse systemic sclerosis patients with high circulating IFNα levels.
Read more11 Oct 2024
19 Sep 2024
02 Sep 2024
01 Sep 2024
28 Aug 2024
publication
Hereditary C1q Deficiency is Associated with Type 1 Interferon-Pathway Activation and a High Risk of Central Nervous System Inflammation.
Read more09 Jul 2024
publication
The brain microvasculature is a primary mediator of interferon-α neurotoxicity in human cerebral interferonopathies.
Read more07 May 2024
publication
Increased levels of GM-CSF and CXCL10 and low CD8+ memory stem T Cell count are markers of immunosenescence and severe COVID-19 in older people.
Read more06 May 2024
publication
Sarcoidosis immunopathogenesis – a new concept of maladaptive trained immunity
Read more07 Mar 2024
27 Feb 2024
event
Milieu Intérieur Satellite Symposium: Human cohort studies for a better understanding of immunity
Read more21 Feb 2024
project
Mise au point d’une méthode d’analyse de la réponse immunitaire physiologique (VARIMMET) : 2023-030
Read more14 Feb 2024
01 Feb 2024
01 Feb 2024
publication
Standardized high-dimensional spectral cytometry protocol and panels for whole blood immune phenotyping in clinical and translational studies.
Read more30 Jan 2024
publication
VEXAS syndrome is characterized by inflammasome activation and monocyte dysregulation.
Read more16 Jan 2024
01 Jan 2024
01 Dec 2023
publication
Unveiling Candida albicans intestinal carriage in healthy volunteers: the role of micro- and mycobiota, diet, host genetics and immune response.
Read more15 Nov 2023
news
New publication – Tuberculosis alters immune-metabolic pathways resulting in perturbed IL-1 responses
Read more05 Oct 2023
publication
Neutralizing antibody levels as a correlate of protection against SARS-CoV-2 infection: a modeling analysis.
Read more09 Aug 2023
01 Aug 2023
18 Jul 2023
publication
T cell migration and effector function differences in familial adenomatous polyposis patients with APC gene mutations
Read more19 Jun 2023
12 May 2023
publication
JAK Inhibition in Aicardi-Goutières Syndrome: a Monocentric Multidisciplinary Real-World Approach Study.
Read more01 Apr 2023
publication
Central Role of Macrophages and Nucleic Acid Release in Myasthenia Gravis Thymus.
Read more15 Mar 2023
project
PERT-SEVERE II – Impact de l’expression bactérienne et de la réponse immunitaire dans la gravité de la coqueluche
Read more17 Jan 2023
publication
Inactive disease in patients with lupus is linked to autoantibodies to type I interferons that normalize blood IFNα and B cell subsets.
Read more02 Jan 2023
publication
Osteonecrosis in patients with juvenile dermatomyositis: is it associated with anti-MDA5 autoantibody?
Read more01 Jan 2023
publication
Targeting the chemokine receptor CXCR4 with histamine analog to reduce inflammation in juvenile arthritis.
Read more05 Dec 2022
publication
Juvenile Neuropsychiatric Systemic Lupus Erythematosus: Identification of Novel Central Neuroinflammation Biomarkers.
Read more25 Nov 2022
publication
Defective activation and regulation of type I interferon immunity is associated with increasing COVID-19 severity.
Read more15 Nov 2022
publication
Enhanced TLR3 responsiveness in hepatitis C virus resistant women from the Irish anti-D cohort.
Read more06 Oct 2022
15 Jul 2022
news
Étude de la réponse immunitaire chez des patients infectés par le SARS-CoV-2 – CoVarImm
Read more28 Jun 2022
publication
Early IFNβ secretion determines variable downstream IL-12p70 responses upon TLR4 activation.
Read more20 Jun 2022
publication
Variability of Primary Sjögren’s Syndrome Is Driven by Interferon-α and Interferon-α Blood Levels Are Associated With the Class II HLA-DQ Locus.
Read more09 Jun 2022
publication
Interferon-α-mediated therapeutic resistance in early rheumatoid arthritis implicates epigenetic reprogramming.
Read more24 May 2022
publication
The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies
Read more28 Apr 2022
publication
Defects in mucosal immunity and nasopharyngeal dysbiosis in HSC-transplanted SCID patients with IL2RG/JAK3 deficiency.
Read more18 Apr 2022
publication
CXCR3 Expression Pattern on CD4+ T Cells and IP-10 Levels with Regard to the HIV-1 Reservoir in the Gut-Associated Lymphatic Tissue.
Read more31 Mar 2022
publication
Activation of NLRP3 Inflammasome in the Skin of Patients with Systemic and Cutaneous Lupus Erythematosus.
Read more28 Mar 2022
news
New publication – Defects in mucosal immunity and nasopharyngeal dysbiosis in HSC transplanted SCID patients with IL2RG/JAK3 deficiency
Read more09 Mar 2022
publication
Integrative genetic and immune cell analysis of plasma proteins in healthy donors identifies novel associations involving primary immune deficiency genes.
Read more23 Feb 2022
publication
Efficacy and tolerance of corticosteroids and methotrexate in patients with juvenile dermatomyositis: a retrospective cohort study.
Read more01 Feb 2022
01 Feb 2022
publication
Primary immune responses are negatively impacted by persistent herpesvirus infections in older people: results from an observational study on healthy subjects and a vaccination trial on subjects aged more than 70 years old.
Read more14 Jan 2022
publication
The risk of COVID-19 death is much greater and age-dependent with type I IFN autoantibodies.
Read more01 Jan 2022
publication
Changes in Systemic Regulatory T Cells, Effector T Cells, and Monocyte Populations Associated With Early-Life Stunting
Read more01 Jan 2022
publication
Tuberculosis alters immune-metabolic pathways resulting in perturbed IL-1 responses.
Read more01 Dec 2021
01 Dec 2021
publication
Type I interferon response and vascular alteration in chilblain-like lesions during the COVID-19 outbreak.
Read more17 Nov 2021
publication
Severe COVID-19 is associated with hyperactivation of the alternative complement pathway.
Read more16 Nov 2021
publication
Kinetics of the Severe Acute Respiratory Syndrome Coronavirus 2 Antibody Response and Serological Estimation of Time Since Infection.
Read more02 Nov 2021
publication
Immune Profiling Enables Stratification of Patients With Active Tuberculosis Disease or Mycobacterium tuberculosis Infection.
Read more01 Nov 2021
publication
Release of infectious virus and cytokines in nasopharyngeal swabs from individuals infected with non-alpha or alpha SARS-CoV-2 variants: an observational retrospective study.
Read more29 Oct 2021
publication
Multi-omic approach identifies a transcriptional network coupling innate immune response to proliferation in the blood of COVID-19 cancer patients.
Read more17 Sep 2021
01 Sep 2021
publication
Distinct systemic and mucosal immune responses during acute SARS-CoV-2 infection.
Read more23 Aug 2021
publication
Onset and Relapse of Juvenile Dermatomyositis Following Asymptomatic SARS-CoV-2 Infection.
Read more19 Aug 2021
publication
Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths.
Read more18 Aug 2021
01 Aug 2021
01 Aug 2021
publication
Immune checkpoint inhibitors increase T cell immunity during SARS-CoV-2 infection.
Read more17 Jul 2021
16 Jul 2021
publication
SARS-CoV-2 infection induces the dedifferentiation of multiciliated cells and impairs mucociliary clearance.
Read more04 Jun 2021
publication
Regulation of the acetylcholine/α7nAChR anti-inflammatory pathway in COVID-19 patients.
Read more17 May 2021
05 May 2021
publication
Ultrasensitive Detection of p24 in Plasma Samples from People with Primary and Chronic HIV-1 Infection.
Read more01 May 2021
publication
HIV DNA reservoir and elevated PD-1 expression of CD4 T-cell subsets particularly persist in the terminal ileum of HIV-positive patients despite cART.
Read more01 Apr 2021
publication
Differential Expression of Interferon-Alpha Protein Provides Clues to Tissue Specificity Across Type I Interferonopathies.
Read more01 Apr 2021
publication
Immune response profiling of patients with spondyloarthritis reveals signalling networks mediating TNF-blocker function in vivo.
Read more03 Mar 2021
12 Feb 2021
publication
JAK inhibitors are effective in a subset of patients with juvenile dermatomyositis: a monocentric retrospective study.
Read more01 Feb 2021
publication
Overview of STING-Associated Vasculopathy with Onset in Infancy (SAVI) Among 21 Patients.
Read more04 Jan 2021
publication
Gut microbiome stability and dynamics in healthy donors and patients with non-gastrointestinal cancers.
Read more04 Jan 2021
publication
TLR3 controls constitutive IFN-β antiviral immunity in human fibroblasts and cortical neurons.
Read more01 Jan 2021
01 Jan 2021
publication
Corrigendum: Unveiling Interindividual Variability of Human Fibroblast Innate Immune Response Using Robust Cell-Based Protocols.
Read more01 Jan 2021
publication
Altered Immune Phenotypes and HLA-DQB1 Gene Variation in Multiple Sclerosis Patients Failing Interferon β Treatment.
Read more01 Jan 2021
publication
Machine Learning-Based Single Cell and Integrative Analysis Reveals That Baseline mDC Predisposition Correlates With Hepatitis B Vaccine Antibody Response.
Read more10 Dec 2020
publication
Associations between untargeted plasma metabolomic signatures and gut microbiota composition in the Milieu Intérieur population of healthy adults.
Read more26 Nov 2020
02 Nov 2020
publication
Mutations in COPA lead to abnormal trafficking of STING to the Golgi and interferon signaling.
Read more23 Oct 2020
publication
Autoantibodies against type I IFNs in patients with life-threatening COVID-19.
Read more15 Oct 2020
publication
Interleukin-7/Interferon axis drives T-cell and salivary gland epithelial cell interactions in Sjögren’s syndrome.
Read more08 Oct 2020
news
Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients
Read more29 Sep 2020
news
Detection of autoantibodies against type I IFNs in patients as a cause of life-threatening COVID-19
Read more24 Sep 2020
publication
Inborn errors of type I IFN immunity in patients with life-threatening COVID-19.
Read more24 Sep 2020
publication
Dysregulation of tryptophan catabolism at the host-skin microbiota interface in Hidradenitis Suppurativa.
Read more19 Sep 2020
publication
Absence of Neuronal Autoantibodies in Neuropsychiatric Systemic Lupus Erythematosus.
Read more28 Aug 2020
event
PhD thesis defence Celine Posseme “Study of natural immune variability to dissect cytokine response pathways”
Read more01 Aug 2020
29 Jul 2020
13 Jul 2020
publication
Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients.
Read more02 Jul 2020
26 Jun 2020
22 Jun 2020
publication
Three Copies of Four Interferon Receptor Genes Underlie a Mild Type I Interferonopathy in Down Syndrome.
Read more19 Jun 2020
publication
Catatonia in a patient with Aicardi-Goutières syndrome efficiently treated with immunoadsorption.
Read more05 Jun 2020
publication
Innate immune stimulation of whole blood reveals IFN-1 hyper-responsiveness in type 1 diabetes.
Read more01 Jun 2020
publication
Antibody-coated microbiota in nasopharynx of healthy individuals and IVIg-treated patients with hypogammaglobulinemia.
Read more27 May 2020
publication
Angiopoietin-2 as a marker of endothelial activation is a good predictor factor for intensive care unit admission of COVID-19 patients.
Read more05 May 2020
publication
Associations between consumption of dietary fibers and the risk of cardiovascular diseases, cancers, type 2 diabetes, and mortality in the prospective NutriNet-Santé cohort.
Read more10 Apr 2020
05 Mar 2020
publication
The proteome of neutrophils in sickle cell disease reveals an unexpected activation of interferon alpha signaling pathway
Read more01 Jan 2020
publication
Neuromyelitis optica in patients with increased interferon alpha concentrations
Read more01 Jan 2020
publication
Systems Biology Methods Applied to Blood and Tissue for a Comprehensive Analysis of Immune Response to Hepatitis B Vaccine in Adults.
Read more01 Jan 2020
publication
Decreased Type I Interferon Production by Plasmacytoid Dendritic Cells Contributes to Severe Dengue.
Read more13 Dec 2019
publication
Severe type I interferonopathy and unrestrained interferon signaling due to a homozygous germline mutation in
Read more26 Nov 2019
26 Nov 2019
22 Nov 2019
publication
Anti-MDA5 juvenile idiopathic inflammatory myopathy: a specific subgroup defined by differentially enhanced interferon-α signalling
Read more05 Nov 2019
30 Oct 2019
publication
Use of ruxolitinib in COPA syndrome manifesting as life-threatening alveolar haemorrhage
Read more30 Oct 2019
publication
Inhibition of IFNα secretion in cells from patients with juvenile dermatomyositis under TBK1 inhibitor treatment revealed by single-molecular assay technology
Read more05 Oct 2019
publication
Risk factors associated with myasthenia gravis in thymoma patients: The potential role of thymic germinal centers
Read more05 Sep 2019
publication
Circulating interferon-α measured with a highly sensitive assay as a biomarker for juvenile inflammatory myositis activity
Read more01 Sep 2019
publication
A comprehensive assessment of demographic, environmental, and host genetic associations with gut microbiome diversity in healthy individuals.
Read more22 Aug 2019
10 Jul 2019
publication
Control of TLR7-mediated type I IFN signaling in pDCs through CXCR4 engagement-A new target for lupus treatment
Read more18 Jun 2019
14 Jun 2019
publication
Type I interferon in patients with systemic autoimmune rheumatic disease is associated with haematological abnormalities and specific autoantibody profiles
Read more30 May 2019
publication
Sex differences in IL-17 contribute to chronicity in male versus female urinary tract infection
Read more22 May 2019
publication
IP-10 contributes to the inhibition of mycobacterial growth in an ex vivo whole blood assay
Read more16 May 2019
event
Department of Immunology seminar: Lydia Lynch, Interdependence of Systemic and Cellular Immunometabolism (Immune Cells are What you Eat)
Read more01 May 2019
publication
Associations between usual diet and gut microbiota composition: results from the Milieu Intérieur cross-sectional study.
Read more29 Apr 2019
publication
Novel DSP Spectrin 6 Region Variant Causes Neonatal Erythroderma, Failure to Thrive, Severe Herpes Simplex Infections and Brain Lesions
Read more23 Apr 2019
08 Apr 2019
publication
Delineating the healthy human skin UV response and early induction of interferon pathway in cutaneous lupus erythematosus
Read more01 Apr 2019
07 Mar 2019
publication
Interferon signature in patients with STAT1 gain-of-function mutation is epigenetically determined
Read more18 Feb 2019
publication
Inhibition of the dipeptidyl peptidase DPP4 (CD26) reveals IL-33-dependent eosinophil-mediated control of tumor growth
Read more06 Dec 2018
01 Nov 2018
12 Oct 2018
project
CoSImmGEn-F : constitution d’une cohorte de sujets atteints de polypose adénomateuse familiale et porteurs d’une mutation du gène APC afin d’étudier le rôle de la génétique du système immunitaire et de l’environnement dans la maladie
Read more03 Oct 2018
publication
Efficacy of JAK1/2 inhibition in the treatment of chilblain lupus due to TREX1 deficiency
Read more24 Sep 2018
22 Sep 2018
07 Sep 2018
publication
First description of agonist and antagonist IP-10 in urine of patients with active TB
Read more05 Sep 2018
publication
Human thymopoiesis is influenced by a common genetic variant within the TCRA-TCRD locus.
Read more27 Jul 2018
publication
Human genetic variants and age are the strongest predictors of humoral immune responses to common pathogens and vaccines.
Read more25 Jul 2018
19 Jul 2018
publication
Identifying the etiology and pathophysiology underlying stunting and environmental enteropathy: study protocol of the AFRIBIOTA project.
Read more05 Jul 2018
publication
Interplay of DDP4 and IP-10 as a Potential Mechanism for Cell Recruitment to Tuberculosis Lesions
Read more01 Jul 2018
publication
Systemic DPP4 activity is reduced during primary HIV-1 infection and is associated with intestinal RORC+ CD4+ cell levels: a surrogate marker candidate of HIV-induced intestinal damage.
Read more29 Jun 2018
19 Jun 2018
publication
Plasmacytoid dendritic cells control dengue and Chikungunya virus infections via IRF7-regulated interferon responses
Read more14 Jun 2018
publication
Development and Validation of an Ultrasensitive Single Molecule Array Digital Enzyme-linked Immunosorbent Assay for Human Interferon-α
Read more01 Jun 2018
publication
JAK inhibitor improves type I interferon induced damage: proof of concept in dermatomyositis
Read more01 Jun 2018
publication
Comment on: ‘Aberrant tRNA processing causes an autoinflammatory syndrome responsive to TNF inhibitors’ by Giannelou : mutations in result in a constitutive activation of type I interferon signalling
Read more01 May 2018
publication
Milieu intérieur: Defining the boundaries of a healthy immune response for improved vaccination strategies
Read more03 Apr 2018
publication
Development and clinical validation of the Genedrive point-of-care test for qualitative detection of hepatitis C virus.
Read more22 Mar 2018
publication
T-cell biomarkers for diagnosis of tuberculosis: candidate evaluation by a simple whole blood assay for clinical translation
Read more01 Mar 2018
publication
Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors.
Read more24 Jan 2018
publication
Parallel derivation of isogenic human primed and naive induced pluripotent stem cells.
Read more16 Jan 2018
publication
Distinctive roles of age, sex, and genetics in shaping transcriptional variation of human immune responses to microbial challenges.
Read more31 Dec 2017
19 Dec 2017
28 Nov 2017
publication
Myogenic Progenitor Cells Exhibit Type I Interferon-Driven Proangiogenic Properties and Molecular Signature During Juvenile Dermatomyositis
Read more21 Sep 2017
publication
Standardized whole blood stimulation improves immunomonitoring of induced immune responses in multi-center study
Read more06 Sep 2017
publication
An in vitro diagnostic certified point of care single nucleotide test for IL28B polymorphisms
Read more31 Aug 2017
publication
Development of a bead-based multiplex assay for the analysis of the serological response against the six pathogens HAV, HBV, HCV, CMV, T. gondii and H. pylori
Read more13 Jul 2017
publication
Deconvolution of the Response to Bacillus Calmette-Guérin Reveals NF-κB-Induced Cytokines As Autocrine Mediators of Innate Immunity
Read more20 Apr 2017
publication
TBK1/IKKE blockade inhibits mutant STING mediated inflammatory response in patient cells
Read more18 Apr 2017
publication
Detection of interferon alpha protein reveals differential levels and cellular sources in disease
Read more15 Mar 2017
publication
Ultrasensitive HIV-1 p24 Assay Detects Single Infected Cells and Differences in Reservoir Induction by Latency Reversal Agents.
Read more20 Oct 2016
publication
Genetic Adaptation and Neandertal Admixture Shaped the Immune System of Human Populations
Read more06 Sep 2016
publication
Standardized Whole-Blood Transcriptional Profiling Enables the Deconvolution of Complex Induced Immune Responses.
Read more26 Aug 2016
25 Aug 2016
publication
Standardized Whole-Blood Transcriptional Profiling Enables the Deconvolution of Complex Induced Immune Responses
Read more24 Mar 2016
publication
Protein biomarkers discriminate Leishmania major-infected and non-infected individuals in areas endemic for cutaneous leishmaniasis
Read more29 Jan 2016
24 Sep 2015
10 Sep 2015
10 Sep 2015
10 Sep 2015
04 Aug 2015
16 Jul 2015
publication
Dynamic Changes of Post-Translationally Modified Forms of CXCL10 and Soluble DPP4 in HCV Subjects Receiving Interferon-Free Therapy
Read more11 Jul 2015
01 Apr 2015
publication
Automated flow cytometric analysis across large numbers of samples and cell types.
Read more01 Apr 2015
publication
Semi-automated and standardized cytometric procedures for multi-panel and multi-parametric whole blood immunophenotyping.
Read more01 Apr 2015
publication
The Milieu Intérieur study – an integrative approach for study of human immunological variance.
Read more01 Oct 2014
publication
Apolipoprotein H expression is associated with IL28B genotype and viral clearance in hepatitis C virus infection.
Read more20 Mar 2014
publication
Functional analysis via standardized whole-blood stimulation systems defines the boundaries of a healthy immune response to complex stimuli.
Read more18 Feb 2014
publication
The ABCs of viral hepatitis that define biomarker signatures of acute viral hepatitis
Read more07 May 2013
publication
CXCL10 antagonism and plasma sDPPIV correlate with increasing liver disease in chronic HCV genotype 4 infected patients
Read more08 Nov 2012
publication
Neutrophils transport antigen from the dermis to the bone marrow, initiating a source of memory CD8+ T cells
Read more04 Jan 2012
publication
Cutting edge: Protective effect of CX3CR1+ dendritic cells in a vaccinia virus pulmonary infection model
Read more15 Dec 2011
publication
Intradermal immunization triggers epidermal Langerhans cell mobilization required for CD8 T-cell immune responses
Read more09 May 2011
publication
CD56brightCD16+ NK cells: a functional intermediate stage of NK cell differentiation
Read more07 May 2011
publication
Targeting of HIV-p24 particle-based vaccine into differential skin layers induces distinct arms of the immune responses
Read more19 Mar 2010
14 Dec 2009
publication
Immunological memory transferred with CD4 T cells specific for tuberculosis antigens Ag85B-TB10.4: persisting antigen enhances protection
Read more07 Dec 2009
publication
Original encounter with antigen determines antigen-presenting cell imprinting of the quality of the immune response in mice
Read more08 Apr 2009
publication
Influence of antigen exposure on the loss of long-term memory to childhood vaccines in HIV-infected patients
Read more04 Dec 2008
publication
Nanoparticle-based targeting of vaccine compounds to skin antigen-presenting cells by hair follicles and their transport in mice
Read more15 Jan 2008
publication
Transgenic CD4 T cells (DO11.10) are destroyed in MHC-compatible hosts by NK cells and CD8 T cells
Read more01 Nov 2006
15 Feb 2006
publication