Timeline

Catherine Werts

Group Leader

29 Jan 2025

publication

Myocarditis and neutrophil-mediated vascular leakage but not cytokine storm associated with fatal murine leptospirosis.

06 Feb 2024

project

Étude de la réponse immunitaire innée au cours de la Leptopirose : LEPTBLOOD (2023-029)

09 Dec 2023

publication

Leptospiral lipopolysaccharide dampens inflammation through upregulation of autophagy adaptor p62 and NRF2 signaling in macrophages.

04 Jan 2023

publication

Leptospira interrogans Prevents Macrophage Cell Death and Pyroptotic IL-1β Release through Its Atypical Lipopolysaccharide.

20 Jan 2022

team

U1306 – Host-Microbe interactions and pathophysiology

01 Jan 2022

publication

Pathogenic Leptospires Limit Dendritic Cell Activation Through Avoidance of TLR4 and TRIF Signaling.

01 Jan 2022

publication

Alive Pathogenic and Saprophytic Leptospires Enter and Exit Human and Mouse Macrophages With No Intracellular Replication.

07 Sep 2021

publication

Recent findings related to immune responses against leptospirosis and novel strategies to prevent infection.

07 Sep 2021

publication

Interaction of Leptospira with the Innate Immune System.

07 Sep 2021

publication

Leptospirosis: a Toll road from B lymphocytes.

01 Mar 2021

publication

Anti-Leptospira immunoglobulin profiling in mice reveals strain specific IgG and persistent IgM responses associated with virulence and renal colonization.

01 Aug 2020

publication

Leptospiral LPS escapes mouse TLR4 internalization and TRIF‑associated antimicrobial responses through O antigen and associated lipoproteins.

01 Jan 2020

publication

Role of TLR4 in Persistent Leptospira interrogans Infection: A Comparative In Vivo Study in Mice.

01 Jan 2020

publication

Phagocyte Escape of Leptospira: The Role of TLRs and NLRs.

01 Jan 2020

publication

In Vivo Imaging of Bioluminescent Leptospires.

01 Jan 2020

publication

The route of infection with Leptospira interrogans serovar Copenhageni affects the kinetics of bacterial dissemination and kidney colonization.

01 Jan 2020

publication

Escape of TLR5 Recognition by Leptospira spp.: A Rationale for Atypical Endoflagella.

01 Jan 2020

publication

Purification of LPS from Leptospira.

01 May 2019

publication

Innate immune memory through TLR2 and NOD2 contributes to the control of Leptospira interrogans infection.

04 Dec 2018

project

PTR66-2017 Role of Toll-Like and Nod-Like Receptors in the activation and functions of phagocytes infected with pathogenic Leptospira

01 Jan 2018

publication

Mycobacterial Phenolic Glycolipids Selectively Disable TRIF-Dependent TLR4 Signaling in Macrophages.

01 Dec 2017

publication

LipL21 lipoprotein binding to peptidoglycan enables Leptospira interrogans to escape NOD1 and NOD2 recognition.

01 Aug 2017

publication

Pre-treatment with Lactobacillus plantarum prevents severe pathogenesis in mice infected with Leptospira interrogans and may be associated with recruitment of myeloid cells.

15 May 2017

publication

LIM-Only Protein FHL2 Is a Negative Regulator of Transforming Growth Factor β1 Expression.

01 Jan 2017

publication

Animal Models of Leptospirosis: Of Mice and Hamsters.

08 Apr 2016

event

Journées du Département de Microbiologie

15 Oct 2015

publication

CCL20 Displays Antimicrobial Activity Against Cryptosporidium parvum, but Its Expression Is Reduced During Infection in the Intestine of Neonatal Mice.

14 Sep 2015

project

ERC-2007-Stg-202283-PGNfromSHAPEtoVIR

16 Jul 2015

team

Group: Innate Immunity and Leptospira

02 Jul 2015

project

Biology and Genetics of Bacterial Cell Wall

01 Jul 2015

publication

Common Cell Shape Evolution of Two Nasopharyngeal Pathogens.

11 May 2015

team

Biology and Genetics of Bacterial Cell Wall

01 Dec 2014

publication

Live imaging of bioluminescent leptospira interrogans in mice reveals renal colonization as a stealth escape from the blood defenses and antibiotics.

23 May 2014

publication

Flagellin/TLR5 signalling activates renal collecting duct cells and facilitates invasion and cellular translocation of uropathogenic Escherichia coli

30 Jan 2014

publication

Calcineurin/NFAT signaling and innate host defence: a role for NOD1-mediated phagocytic functions

01 Jan 2014

publication

Leptospira Interrogans induces fibrosis in the mouse kidney through Inos-dependent, TLR- and NLR-independent signaling pathways.

06 Sep 2013

publication

Poly(I:C)-induced protection of neonatal mice against intestinal Cryptosporidium parvum infection requires an additional TLR5 signal provided by the gut flora

01 Aug 2013

publication

LIM-only protein FHL2 activates NF-κB signaling in the control of liver regeneration and hepatocarcinogenesis.

12 Jun 2013

publication

Penicillin resistance compromises Nod1-dependent proinflammatory activity and virulence fitness of neisseria meningitidis.

31 Jan 2013

publication

Cyclosporine A impairs nucleotide binding oligomerization domain (Nod1)-mediated innate antibacterial renal defenses in mice and human transplant recipients

01 Jan 2013

publication

Intestinal CD103+ dendritic cells are key players in the innate immune control of Cryptosporidium parvum infection in neonatal mice.

01 Jun 2012

publication

The effect of bulgecin A on peptidoglycan metabolism and physiology of Helicobacter pylori.

15 Mar 2012

publication

Downregulation of the Na/K-ATPase pump by leptospiral glycolipoprotein activates the NLRP3 inflammasome.

01 Sep 2011

publication

Nod-like receptors in intestinal homeostasis, inflammation, and cancer.

19 May 2010

publication

TLR9-dependent induction of intestinal alpha-defensins by Toxoplasma gondii

12 Mar 2010

publication

Heat shock protein gp96 and NAD(P)H oxidase 4 play key roles in Toll-like receptor 4-activated apoptosis during renal ischemia/reperfusion injury

27 Jul 2009

publication

TLR4- and TLR2-mediated B cell responses control the clearance of the bacterial pathogen, Leptospira interrogans

05 Mar 2009

publication

Heat shock protein gp96 interacts with protein phosphatase 5 and controls toll-like receptor 2 (TLR2)-mediated activation of extracellular signal-regulated kinase (ERK) 1/2 in post-hypoxic kidney cells

27 Nov 2008

publication

Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis.

01 Mar 2008

publication

The ubiquitin-editing enzyme A20 restricts nucleotide-binding oligomerization domain containing 2-triggered signals

01 Feb 2008

publication

[Molecular cross talk between Toxoplasma gondii and the host immune system].

01 Sep 2007

publication

Nod1 and Nod2 induce CCL5/RANTES through the NF-kappaB pathway.

01 Apr 2007

publication

Role of Nods in bacterial infection.

19 Jan 2007

publication

Simple method for repurification of endotoxins for biological use

01 Oct 2006

publication

Toxoplasma gondii and subversion of the immune system.

01 Oct 2006

publication

Renal collecting duct epithelial cells react to pyelonephritis-associated Escherichia coli by activating distinct TLR4-dependent and -independent inflammatory pathways

01 Sep 2006

publication

Role of AmiA in the morphological transition of Helicobacter pylori and in immune escape.

01 May 2006

publication

TIR, CARD and PYRIN: three domains for an antimicrobial triad

01 Nov 2005

publication

Differential TLR recognition of leptospiral lipid A and lipopolysaccharide in murine and human cells.

22 Aug 2005

publication

The frameshift mutation in Nod2 results in unresponsiveness not only to Nod2- but also Nod1-activating peptidoglycan agonists

01 Aug 2005

publication

Synergistic stimulation of human monocytes and dendritic cells by Toll-like receptor 4 and NOD1- and NOD2-activating agonists.

01 Oct 2004

publication

Toll-like receptor 2-dependent bacterial sensing does not occur via peptidoglycan recognition.

24 Mar 2004

publication

A methylated phosphate group and four amide-linked acyl chains in leptospira interrogans lipid A. The membrane anchor of an unusual lipopolysaccharide that activates TLR2

24 Mar 2004

publication

Enzymatic synthesis of lipid A molecules with four amide-linked acyl chains. LpxA acyltransferases selective for an analog of UDP-N-acetylglucosamine in which an amine replaces the 3″-hydroxyl group

02 Jan 2004

publication

Helicobacter pylori heat shock protein 60 mediates interleukin-6 production by macrophages via a toll-like receptor (TLR)-2-, TLR-4-, and myeloid differentiation factor 88-independent mechanism.

15 Jul 2003

publication

Toll-like receptor-mediated tumor necrosis factor and interleukin-10 production differ during systemic inflammation.

20 Feb 2003

publication

Inhibition by eicosapentaenoic acid of IL-1beta-induced PGHS-2 expression in human microvascular endothelial cells: involvement of lipoxygenase-derived metabolites and p38 MAPK pathway.

01 Aug 2002

publication

TNF-alpha, inefficient by itself, potentiates IL-1beta-induced PGHS-2 expression in human pulmonary microvascular endothelial cells: requirement of NF-kappaB and p38 MAPK pathways.

24 Jul 2001

publication

First evidence for a restriction-modification system in Leptospira sp

01 Apr 2001

publication

Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism

01 Jun 1994

publication

A role for residue 151 of LamB in bacteriophage lambda adsorption: possible steric effect of amino acid substitutions

01 Feb 1994

publication

Adsorption of bacteriophage lambda on the LamB protein of Escherichia coli K-12: point mutations in gene J of lambda responsible for extended host range

01 May 1993

publication

Construction and first characterization of two reciprocal hybrids between LamB from Escherichia coli K12 and Klebsiella pneumoniae

01 Apr 1993

publication

Immunological relatedness of the LamB proteins among members of Enterobacteriaceae

01 Jun 1992

publication

DNA sequence analysis of the lamB gene from Klebsiella pneumoniae: implications for the topology and the pore functions in maltoporin

01 Feb 1991

publication

A genetic system to elicit and monitor antipeptide antibodies without peptide synthesis

01 Jan 1991

publication

A little guide for advanced search:

Myocarditis and neutrophil-mediated vascular leakage but not cytokine storm associated with fatal murine leptospirosis.

Étude de la réponse immunitaire innée au cours de la Leptopirose : LEPTBLOOD (2023-029)

Leptospiral lipopolysaccharide dampens inflammation through upregulation of autophagy adaptor p62 and NRF2 signaling in macrophages.

Leptospira interrogans Prevents Macrophage Cell Death and Pyroptotic IL-1β Release through Its Atypical Lipopolysaccharide.

U1306 – Host-Microbe interactions and pathophysiology

Pathogenic Leptospires Limit Dendritic Cell Activation Through Avoidance of TLR4 and TRIF Signaling.

Alive Pathogenic and Saprophytic Leptospires Enter and Exit Human and Mouse Macrophages With No Intracellular Replication.

Recent findings related to immune responses against leptospirosis and novel strategies to prevent infection.

Interaction of Leptospira with the Innate Immune System.

Leptospirosis: a Toll road from B lymphocytes.

Anti-Leptospira immunoglobulin profiling in mice reveals strain specific IgG and persistent IgM responses associated with virulence and renal colonization.

Leptospiral LPS escapes mouse TLR4 internalization and TRIF‑associated antimicrobial responses through O antigen and associated lipoproteins.

Role of TLR4 in Persistent Leptospira interrogans Infection: A Comparative In Vivo Study in Mice.

Phagocyte Escape of Leptospira: The Role of TLRs and NLRs.

In Vivo Imaging of Bioluminescent Leptospires.

The route of infection with Leptospira interrogans serovar Copenhageni affects the kinetics of bacterial dissemination and kidney colonization.

Escape of TLR5 Recognition by Leptospira spp.: A Rationale for Atypical Endoflagella.

Purification of LPS from Leptospira.

Innate immune memory through TLR2 and NOD2 contributes to the control of Leptospira interrogans infection.

PTR66-2017 Role of Toll-Like and Nod-Like Receptors in the activation and functions of phagocytes infected with pathogenic Leptospira

Mycobacterial Phenolic Glycolipids Selectively Disable TRIF-Dependent TLR4 Signaling in Macrophages.

LipL21 lipoprotein binding to peptidoglycan enables Leptospira interrogans to escape NOD1 and NOD2 recognition.

Pre-treatment with Lactobacillus plantarum prevents severe pathogenesis in mice infected with Leptospira interrogans and may be associated with recruitment of myeloid cells.

LIM-Only Protein FHL2 Is a Negative Regulator of Transforming Growth Factor β1 Expression.

Animal Models of Leptospirosis: Of Mice and Hamsters.

Journées du Département de Microbiologie

CCL20 Displays Antimicrobial Activity Against Cryptosporidium parvum, but Its Expression Is Reduced During Infection in the Intestine of Neonatal Mice.

ERC-2007-Stg-202283-PGNfromSHAPEtoVIR

Group: Innate Immunity and Leptospira

Biology and Genetics of Bacterial Cell Wall

Common Cell Shape Evolution of Two Nasopharyngeal Pathogens.

Biology and Genetics of Bacterial Cell Wall

Live imaging of bioluminescent leptospira interrogans in mice reveals renal colonization as a stealth escape from the blood defenses and antibiotics.

Flagellin/TLR5 signalling activates renal collecting duct cells and facilitates invasion and cellular translocation of uropathogenic Escherichia coli

Calcineurin/NFAT signaling and innate host defence: a role for NOD1-mediated phagocytic functions

Leptospira Interrogans induces fibrosis in the mouse kidney through Inos-dependent, TLR- and NLR-independent signaling pathways.

Poly(I:C)-induced protection of neonatal mice against intestinal Cryptosporidium parvum infection requires an additional TLR5 signal provided by the gut flora

LIM-only protein FHL2 activates NF-κB signaling in the control of liver regeneration and hepatocarcinogenesis.

Penicillin resistance compromises Nod1-dependent proinflammatory activity and virulence fitness of neisseria meningitidis.

Cyclosporine A impairs nucleotide binding oligomerization domain (Nod1)-mediated innate antibacterial renal defenses in mice and human transplant recipients

Intestinal CD103+ dendritic cells are key players in the innate immune control of Cryptosporidium parvum infection in neonatal mice.

The effect of bulgecin A on peptidoglycan metabolism and physiology of Helicobacter pylori.

Downregulation of the Na/K-ATPase pump by leptospiral glycolipoprotein activates the NLRP3 inflammasome.

Nod-like receptors in intestinal homeostasis, inflammation, and cancer.

TLR9-dependent induction of intestinal alpha-defensins by Toxoplasma gondii

Heat shock protein gp96 and NAD(P)H oxidase 4 play key roles in Toll-like receptor 4-activated apoptosis during renal ischemia/reperfusion injury

TLR4- and TLR2-mediated B cell responses control the clearance of the bacterial pathogen, Leptospira interrogans

Heat shock protein gp96 interacts with protein phosphatase 5 and controls toll-like receptor 2 (TLR2)-mediated activation of extracellular signal-regulated kinase (ERK) 1/2 in post-hypoxic kidney cells

Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis.

The ubiquitin-editing enzyme A20 restricts nucleotide-binding oligomerization domain containing 2-triggered signals

[Molecular cross talk between Toxoplasma gondii and the host immune system].

Nod1 and Nod2 induce CCL5/RANTES through the NF-kappaB pathway.

Role of Nods in bacterial infection.

Simple method for repurification of endotoxins for biological use

Toxoplasma gondii and subversion of the immune system.

Renal collecting duct epithelial cells react to pyelonephritis-associated Escherichia coli by activating distinct TLR4-dependent and -independent inflammatory pathways

Role of AmiA in the morphological transition of Helicobacter pylori and in immune escape.

TIR, CARD and PYRIN: three domains for an antimicrobial triad

Differential TLR recognition of leptospiral lipid A and lipopolysaccharide in murine and human cells.

The frameshift mutation in Nod2 results in unresponsiveness not only to Nod2- but also Nod1-activating peptidoglycan agonists

Synergistic stimulation of human monocytes and dendritic cells by Toll-like receptor 4 and NOD1- and NOD2-activating agonists.

Toll-like receptor 2-dependent bacterial sensing does not occur via peptidoglycan recognition.

A methylated phosphate group and four amide-linked acyl chains in leptospira interrogans lipid A. The membrane anchor of an unusual lipopolysaccharide that activates TLR2

Enzymatic synthesis of lipid A molecules with four amide-linked acyl chains. LpxA acyltransferases selective for an analog of UDP-N-acetylglucosamine in which an amine replaces the 3″-hydroxyl group

Helicobacter pylori heat shock protein 60 mediates interleukin-6 production by macrophages via a toll-like receptor (TLR)-2-, TLR-4-, and myeloid differentiation factor 88-independent mechanism.

Toll-like receptor-mediated tumor necrosis factor and interleukin-10 production differ during systemic inflammation.

Inhibition by eicosapentaenoic acid of IL-1beta-induced PGHS-2 expression in human microvascular endothelial cells: involvement of lipoxygenase-derived metabolites and p38 MAPK pathway.

TNF-alpha, inefficient by itself, potentiates IL-1beta-induced PGHS-2 expression in human pulmonary microvascular endothelial cells: requirement of NF-kappaB and p38 MAPK pathways.

First evidence for a restriction-modification system in Leptospira sp

Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism

A role for residue 151 of LamB in bacteriophage lambda adsorption: possible steric effect of amino acid substitutions

Adsorption of bacteriophage lambda on the LamB protein of Escherichia coli K-12: point mutations in gene J of lambda responsible for extended host range

Construction and first characterization of two reciprocal hybrids between LamB from Escherichia coli K12 and Klebsiella pneumoniae

Immunological relatedness of the LamB proteins among members of Enterobacteriaceae

DNA sequence analysis of the lamB gene from Klebsiella pneumoniae: implications for the topology and the pore functions in maltoporin

A genetic system to elicit and monitor antipeptide antibodies without peptide synthesis

Permissive sites and topology of an outer membrane protein with a reporter epitope