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© Research
Project

PTR66-2017 Role of Toll-Like and Nod-Like Receptors in the activation and functions of phagocytes infected with pathogenic Leptospira

Scientific Fields
Diseases
Organisms
Applications
Technique
Starting Date
04
Dec 2018
Status
Ongoing
Members
3

About

We showed that Leptospira escape recognition by some innate immune receptors of the Toll-like (TLR) and Nod-Like families (NLR). We wonder whether this escape is responsible for the deficient phagocytic activity towards leptospires or the lack of immune memory impairing vaccination.
In this PTR in collaboration with Mariko Matsui and Julie Cagliero (IPNC) and Jessica Quintin (IP), we aim to study in vitro and ex vivo how pathogenic leptospires are recognized and processed by phagocytes (macrophages, neutrophils and dendritic cells), using mouse and human cells. We will focus on their recognition or escape from pathways linked to activation of TLR or NLR.
We will also test trained immunity approaches to enhance the phagocytic defense against pathogenic leptospires, and hopefully alleviate experimental leptospirosis, in mice and hamsters.