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© Christine Schmitt, Meriem El Ghachi, Jean-Marc Panaud
Bactérie Helicobacter pylori en microscopie électronique à balayage. Agent causal de pathologies de l'estomac : elle est responsable des gastrites chroniques, d'ulcères gastriques et duodénaux et elle joue un rôle important dans la genèse des cancers gastriques (adénocarcinomes et lymphomes).
Publication : Journal of leukocyte biology

Nod-like receptors in intestinal homeostasis, inflammation, and cancer

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of leukocyte biology - 07 Jun 2011

Werts C, Rubino S, Ling A, Girardin SE, Philpott DJ

Link to Pubmed [PMID] – 21653239

J. Leukoc. Biol. 2011 Sep;90(3):471-82

NLRs have been shown in a number of models to protect against microbial infection through their ability to participate in “pattern recognition” and their triggering of inflammatory pathways to control infection. Over the past few years, however, the role of NLRs, especially Nod1, Nod2, and NLRP3, in intestinal homeostasis has been highlighted. Indeed, these specific NLRs have been implicated in IBD, in particular, the association of Nod2 with CD, yet a clear understanding of how dysfunctional NLR activation leads to aberrant inflammation is still the focus of much investigation. In this review, we will examine how NLRs participate in the maintenance of gut homeostasis and how upset of this regulation can tip the balance toward chronic inflammation and intestinal cancer.

http://www.ncbi.nlm.nih.gov/pubmed/21653239