Epigénomique, Prolifération et Identité Cellulaire

The study of ES cells has not escaped the recent explosion of regulatory lncRNA biology: from the thousands of lncRNAs that have been identified across the mouse genome a large subset is expressed in […]

To maintain the undifferentiated state, ES cells need to keep silent differentiation genes. However, the genetic invalidation of key systems of epigenetic repression (Polycomb, H3K9 and CpG methylation) does not impair ES cells self-renewal. This suggests that […]

Self-renewing ES cells display dramatic cell-to-cell variability in the expression level of key transcription factors such as Nanog. Whereas Nanog-positive cells self-renew efficiently, Nanog-negative cells are prone to differentiate. Although these two populations can dynamically inter-convert, very […]