ERC-2017-COG_BinD – Mitotic Bookmarking, Stem Cells and early Development
The goal of this project is to deliver a new theoretical framework to understand how transcription factors (TFs) sustain cell identity during developmental processes. Recognised as key drivers of cell fate acquisition, TFs are […]
Follicular growth and ovarian endocrine function
In mammals, ovaries contain a definite number of follicles, each containing a germ cell, the oocyte. The production of fertilizable ovocytes involves complex molecular, cellular, paracrine and endocrine mechanisms and requires a growth phase […]
Epiblast/Primitive Endoderm specification and differentiation during early mouse development
The mammalian preimplantation embryo is a model of choice to study these processes and derivation of stem cells from early embryos has generated a lot of interest for this period of development. Mammalian development […]
Inheritance of the pluripotency network’s activity
The preservation of pluripotency throughout cell division – self-renewal -, is strictly dependent on the highly efficient action of the pluripotency gene regulatory network. However, how TFs cope with replication and mitosis, two major […]
Notch Activity Sensor (NAS) transgenic mouse line
Because of the various levels of regulation of the Notch pathway, its activity cannot be easily deduced from the expression profiles of its components. In order to visualize Notch activity in situ at the cellular level, […]
2019CTCF confers local nucleosome resiliency after DNA replication and during mitosis, Elife 2019 Oct;8.
2019PDGF signaling in primitive endoderm cell survival is mediated by PI3K-mTOR through p53-independent mechanism, Stem Cells 2019 Mar;.
2019Transcription factor activity and nucleosome organization in mitosis, Genome Res. 2019 Jan;.
2018Mouse adult hematopoietic stem cells actively synthetize ribosomal RNA, RNA 2018 Dec;24(12):1803-1812.
2018Argonaute 2 Is Required for Extra-embryonic Endoderm Differentiation of Mouse Embryonic Stem Cells, Stem Cell Reports 2018 Jan;.
2017ICM conversion to epiblast by FGF/ERK inhibition is limited in time and requires transcription and protein degradation, Sci Rep 2017 Sep;7(1):12285.
2017Optimization of the production of knock-in alleles by CRISPR/Cas9 microinjection into the mouse zygote, Sci Rep 2017 Feb;7:42661.
2016Mitotic binding of Esrrb marks key regulatory regions of the pluripotency network, Nat. Cell Biol. 2016 Oct;.