Michel Cohen-Tannoudji

The goal of this project is to deliver a new theoretical framework to understand how transcription factors (TFs) sustain cell identity during developmental processes. Recognised as key drivers of cell fate acquisition, TFs are […]

In mammals, ovaries contain a definite number of follicles, each containing a germ cell, the oocyte. The production of fertilizable ovocytes involves complex molecular, cellular, paracrine and endocrine mechanisms and requires a growth phase […]

The mammalian preimplantation embryo is a model of choice to study these processes and derivation of stem cells from early embryos has generated a lot of interest for this period of development. Mammalian development […]

The preservation of pluripotency throughout cell division – self-renewal -, is strictly dependent on the highly efficient action of the pluripotency gene regulatory network. However, how TFs cope with replication and mitosis, two major […]

Self-renewing ES cells display dramatic cell-to-cell variability in the expression level of key transcription factors such as Nanog. Whereas Nanog-positive cells self-renew efficiently, Nanog-negative cells are prone to differentiate. Although these two populations can dynamically inter-convert, very […]

Because of the various levels of regulation of the Notch pathway, its activity cannot be easily deduced from the expression profiles of its components. In order to visualize Notch activity in situ at the cellular level, […]

      The H-2Z1 transgenic line which exhibits a striking and unexpected expression profile. In this line, lacZ expression in the cerebral cortex is restricted to a subset of layer IV neurons and delineates precisely […]