Mouse Genetics Course
This five-week intensive laboratory and lecture course covers the analysis of gene function at all levels: the gene and its product, the cell and its interactions, the embryonic tissues and the entire animal. This […]
ERC-2017-COG_BinD – Mitotic Bookmarking, Stem Cells and early Development
The goal of this project is to deliver a new theoretical framework to understand how transcription factors (TFs) sustain cell identity during developmental processes. Recognised as key drivers of cell fate acquisition, TFs are […]
Follicular growth and ovarian endocrine function
In mammals, ovaries contain a definite number of follicles, each containing a germ cell, the oocyte. The production of fertilizable ovocytes involves complex molecular, cellular, paracrine and endocrine mechanisms and requires a growth phase […]
Epiblast/Primitive Endoderm specification and differentiation during early mouse development
The mammalian preimplantation embryo is a model of choice to study these processes and derivation of stem cells from early embryos has generated a lot of interest for this period of development. Mammalian development […]
Inheritance of the pluripotency network’s activity
The preservation of pluripotency throughout cell division – self-renewal -, is strictly dependent on the highly efficient action of the pluripotency gene regulatory network. However, how TFs cope with replication and mitosis, two major […]
The epigenetic foundation of gene expression heterogeneity
Self-renewing ES cells display dramatic cell-to-cell variability in the expression level of key transcription factors such as Nanog. Whereas Nanog-positive cells self-renew efficiently, Nanog-negative cells are prone to differentiate. Although these two populations can dynamically inter-convert, very […]
Notch Activity Sensor (NAS) transgenic mouse line
Because of the various levels of regulation of the Notch pathway, its activity cannot be easily deduced from the expression profiles of its components. In order to visualize Notch activity in situ at the cellular level, […]
2019CTCF confers local nucleosome resiliency after DNA replication and during mitosis, Elife 2019 Oct;8.
2019PDGF signaling in primitive endoderm cell survival is mediated by PI3K-mTOR through p53-independent mechanism, Stem Cells 2019 Mar;.
2019Transcription factor activity and nucleosome organization in mitosis, Genome Res. 2019 Jan;.
2018Notchless defines a stage-specific requirement for ribosome biogenesis during lineage progression in adult skeletal myogenesis, Development 2018 Nov;145(23).
2018Mouse adult hematopoietic stem cells actively synthetize ribosomal RNA, RNA 2018 Dec;24(12):1803-1812.
2018Argonaute 2 Is Required for Extra-embryonic Endoderm Differentiation of Mouse Embryonic Stem Cells, Stem Cell Reports 2018 Jan;.
2017ICM conversion to epiblast by FGF/ERK inhibition is limited in time and requires transcription and protein degradation, Sci Rep 2017 Sep;7(1):12285.
2017A multiscale model of early cell lineage specification including cell division, Npj Systems Biology and Applications, 3(1), 16..
2017A multiscale model of early cell lineage specification including cell division, NPJ Syst Biol Appl 2017;3:16.
2017Optimization of the production of knock-in alleles by CRISPR/Cas9 microinjection into the mouse zygote, Sci Rep 2017 Feb;7:42661.
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