Timeline

Marcel Hollenstein
Head of Structure
09 Sep 2019
event

Department of Structural biology and chemistry seminar: Dr; David M. Perrin, Selection of RNaseA-mimicking DNAzymes with amines, imidazoles, and guanidines that cleave RNA: from unnatural aptamer selections unto to the origin of life

Read more
04 Sep 2019
event

Department of Structural Biology and Chemistry: David M. Perrin, Selection of RNaseA-mimicking DNAzymes with amines, imidazoles, and guanidines that cleave RNA: from unnatural aptamer selections unto to the origin of life

Read more
19 Aug 2019
publication

Compatibility of 5-ethynyl-2’F-ANA UTP with in vitro selection for the generation of base-modified, nuclease resistant aptamers

Read more
14 Jul 2019
publication

Nucleic acid enzymes based on functionalized nucleosides

Read more
17 May 2019
publication

Synthesis and Enzymatic Characterization of Sugar-Modified Nucleoside Triphosphate Analogs

Read more
15 May 2019
publication

Chemical methods for the modification of RNA

Read more
29 Mar 2019
publication

Terminal Deoxynucleotidyl Transferase in the Synthesis and Modification of Nucleic Acids

Read more
02 Feb 2019
publication

Towards the enzymatic formation of artificial metal base pairs with a carboxy-imidazole-modified nucleotide

Read more
07 Dec 2018
event

Seminar Structural Biochemistry and Chemistry Department: Dr. Shana Sturla

Read more
07 Dec 2018
event

Seminar of the Structural Biology and Chemistry department: Mélanie Etheve-Quelquejeu

Read more
21 Oct 2018
publication

Incorporation of a minimal nucleotide into DNA

Read more
22 Aug 2018
project

Expansion of the genetic alphabet with metal base pairs

Read more
22 Aug 2018
project

Therapeutic tools based on nucleic acids

Read more
23 Jul 2018
publication

Shaping Rolling Circle Amplification Products into DNA Nanoparticles by Incorporation of Modified Nucleotides and Their Application to In Vitro and In Vivo Delivery of a Photosensitizer

Read more
23 Jul 2018
publication

Tetrahedral DNAzymes for enhanced intracellular gene-silencing activity

Read more
06 Apr 2018
event

Seminar of the Department of Structural Biology and Chemistry

Read more
04 Apr 2018
publication

Aptamer chemistry

Read more
24 Jan 2018
publication

DNA Synthesis by Primer Exchange Reaction Cascades

Read more
19 Jun 2017
publication

Enzymatic Synthesis of 7’,5’-Bicyclo-DNA Oligonucleotides

Read more
01 May 2017
publication

On the enzymatic incorporation of an imidazole nucleotide into DNA

Read more
17 Mar 2017
project

Synthesis of chemically modified nucleoside triphosphates

Read more
04 Feb 2017
publication

New synthetic route to ethynyl-dUTP: A means to avoid formation of acetyl and chloro vinyl base-modified triphosphates that could poison SELEX experiments

Read more
05 Dec 2016
publication

Rolling circle amplification with chemically modified nucleoside triphosphates

Read more
12 Jan 2016
team

Bioorganic chemistry of nucleic acids

Read more
20 Nov 2015
publication

DNA Catalysis: The Chemical Repertoire of DNAzymes

Read more
14 Oct 2015
publication

Generation of long, fully modified, and serum-resistant oligonucleotides by rolling circle amplification

Read more
14 Sep 2015
publication

Generation of Aptamers with an Expanded Chemical Repertoire

Read more
01 May 2015
publication

Probing the effect of minor groove interactions on the catalytic efficiency of DNAzymes 8-17 and 10-23

Read more
25 Jan 2015
publication

A method for selecting modified DNAzymes without the use of modified DNA as a template in PCR

Read more
17 Jul 2014
publication

Synthesis and biochemical characterization of tricyclothymidine triphosphate (tc-TTP)

Read more
03 Apr 2014
publication

Nucleoside triphosphates–from synthesis to biochemical characterization

Read more
02 Jul 2013
publication

Deoxynucleoside triphosphates bearing histamine, carboxylic acid, and hydroxyl residues–synthesis and biochemical characterization

Read more
13 Mar 2013
publication

Toward the combinatorial selection of chemically modified DNAzyme RNase A mimics active against all-RNA substrates

Read more
15 Nov 2012
publication

Nucleoside triphosphates–building blocks for the modification of nucleic acids

Read more
20 Sep 2012
publication

Synthesis of deoxynucleoside triphosphates that include proline, urea, or sulfonamide groups and their polymerase incorporation into DNA

Read more
05 May 2012
publication

Polymerase incorporation of pyrene-nucleoside triphosphates

Read more
13 Jun 2011
publication

A divalent metal-dependent self-cleaving DNAzyme with a tyrosine side chain

Read more
10 Feb 2011
publication

Protein-inspired modified DNAzymes: dramatic effects of shortening side-chain length of 8-imidazolyl modified deoxyadenosines in selecting RNaseA mimicking DNAzymes

Read more
01 Jan 2011
publication

Expanding the catalytic repertoire of DNAzymes by modified nucleosides

Read more
17 Aug 2009
publication

A DNAzyme with three protein-like functional groups: enhancing catalytic efficiency of M2+-independent RNA cleavage

Read more
19 Jan 2009
publication

A self-cleaving DNA enzyme modified with amines, guanidines and imidazoles operates independently of divalent metal cations (M2+)

Read more
01 Jan 2008
publication

In vitro selection of a DNAzyme with three modified nucleotides

Read more
01 Jan 2008
publication

A highly selective DNAzyme sensor for mercuric ions

Read more
15 Apr 2005
publication

Fluorinated olefinic peptide nucleic acid: synthesis and pairing properties with complementary DNA

Read more
29 May 2003
publication

Synthesis and incorporation into PNA of fluorinated olefinic PNA (F-OPA) monomers

Read more
01 May 2003
publication

Fluorinated peptide nucleic acid

Read more
08 Jun 2000
publication

Diborane nitrogenrammonia plasma chemistry investigated by infrared absorption spectroscopy

Read more