Timeline
Marcel Hollenstein
Head of Structure
13 Sep 2024
publication
Template-dependent DNA ligation for the synthesis of modified oligonucleotides.
Read more13 Sep 2024
publication
Template-dependent DNA ligation for the synthesis of modified oligonucleotides.
Read more12 Jul 2024
event
3rd Drug Discovery & Screening Symposium – “Innovative Therapeutics: Small Molecules and Biologics in Modern Medicine” – an ATC-DDS initiative
Read more08 Jul 2024
publication
A toolbox for enzymatic modification of nucleic acids with photosensitizers for photodynamic therapy
Read more18 Jun 2024
20 Nov 2023
publication
Expedient synthesis of l-heptose derived septacidin building blocks from l-glucose
Read more15 Nov 2023
01 Nov 2023
publication
Increasing the π-Expansive Ligands in Ruthenium(II) Polypyridyl Complexes: Synthesis, Characterization, and Biological Evaluation for Photodynamic Therapy Applications
Read more28 Aug 2023
15 Mar 2023
project
CoVariant – Comprendre les déterminants de l’immunité muqueuse et optimiser le diagnostic de l’infection aux variants du SARS-CoV-2
Read more01 Jan 2023
publication
Towards the controlled enzymatic synthesis of LNA containing oligonucleotides.
Read more15 Dec 2022
30 Nov 2022
publication
High-Content RNAi Phenotypic Screening Unveils the Involvement of Human Ubiquitin-Related Enzymes in Late Cytokinesis
Read more26 Oct 2022
publication
Ferrocene as a potential electrochemical reporting surrogate of abasic sites in DNA
Read more11 Sep 2022
26 Aug 2022
26 Aug 2022
publication
Benzoyl and pivaloyl as efficient protecting groups for controlled enzymatic synthesis of DNA and XNA oligonucleotides
Read more01 Jun 2022
publication
Evaluation of 3′-phosphate as a transient protecting group for controlled enzymatic synthesis of DNA and XNA oligonucleotides
Read more01 Jun 2022
publication
Evaluation of 3′-phosphate as a transient protecting group for controlled enzymatic synthesis of DNA and XNA oligonucleotides.
Read more08 Mar 2022
05 Jan 2022
publication
A ruthenium-oligonucleotide bioconjugated photosensitizing aptamer for cancer cell specific photodynamic therapy
Read more18 Nov 2021
31 Oct 2021
publication
A ruthenium-oligonucleotide bioconjugated photosensitizing aptamer for cancer cell specific photodynamic therapy
Read more01 Sep 2021
publication
A ruthenium-oligonucleotide bioconjugated photosensitizing aptamer for cancer cell specific photodynamic therapy
Read more07 Jul 2021
publication
Towards the enzymatic synthesis of phosphorothioate containing LNA oligonucleotides
Read more29 Apr 2021
27 Apr 2021
14 Apr 2021
22 Oct 2020
publication
Enzymatic Formation of an Artificial Base Pair Using a Modified Purine Nucleoside Triphosphate
Read more16 Jul 2020
publication
Enzymatic Construction of Artificial Base Pairs: The Effect of Metal Shielding
Read more06 Jul 2020
publication
Evolution of abiotic cubane chemistries in a nucleic acid aptamer allows selective recognition of a malaria biomarker.
Read more15 May 2020
07 May 2020
20 Mar 2020
19 Mar 2020
publication
Self‐Assembly of DNA and RNA Building Blocks Explored by Nitrogen‐14 NMR Crystallography: Structure and Dynamics
Read more25 Feb 2020
30 Jan 2020
publication
Ruthenium-initiated polymerization of lactide: a route to remarkable cellular uptake for photodynamic therapy of cancer
Read more30 Jan 2020
publication
Ruthenium-initiated polymerization of lactide: a route to remarkable cellular uptake for photodynamic therapy of cancer.
Read more23 Dec 2019
publication
Enzymatic Formation of an Artificial Base Pair Using a Modified Adenine Nucleoside Triphosphate
Read more13 Dec 2019
publication
On the Enzymatic Formation of Metal Base Pairs with Thiolated and pKa-Perturbed Nucleotides
Read more09 Sep 2019
event
Department of Structural biology and chemistry seminar: Dr; David M. Perrin, Selection of RNaseA-mimicking DNAzymes with amines, imidazoles, and guanidines that cleave RNA: from unnatural aptamer selections unto to the origin of life
Read more04 Sep 2019
event
Department of Structural Biology and Chemistry: David M. Perrin, Selection of RNaseA-mimicking DNAzymes with amines, imidazoles, and guanidines that cleave RNA: from unnatural aptamer selections unto to the origin of life
Read more19 Aug 2019
publication
Compatibility of 5-ethynyl-2’F-ANA UTP with in vitro selection for the generation of base-modified, nuclease resistant aptamers
Read more14 Jul 2019
17 May 2019
publication
Synthesis and Enzymatic Characterization of Sugar-Modified Nucleoside Triphosphate Analogs
Read more15 May 2019
29 Mar 2019
publication
Terminal Deoxynucleotidyl Transferase in the Synthesis and Modification of Nucleic Acids
Read more02 Feb 2019
publication
Towards the enzymatic formation of artificial metal base pairs with a carboxy-imidazole-modified nucleotide
Read more07 Dec 2018
07 Dec 2018
event
Seminar of the Structural Biology and Chemistry department: Mélanie Etheve-Quelquejeu
Read more21 Oct 2018
22 Aug 2018
22 Aug 2018
23 Jul 2018
publication
Shaping Rolling Circle Amplification Products into DNA Nanoparticles by Incorporation of Modified Nucleotides and Their Application to In Vitro and In Vivo Delivery of a Photosensitizer
Read more23 Jul 2018
06 Apr 2018
04 Apr 2018
24 Jan 2018
19 Jun 2017
01 May 2017
17 Mar 2017
04 Feb 2017
publication
New synthetic route to ethynyl-dUTP: A means to avoid formation of acetyl and chloro vinyl base-modified triphosphates that could poison SELEX experiments
Read more05 Dec 2016
publication
Rolling circle amplification with chemically modified nucleoside triphosphates
Read more12 Jan 2016
20 Nov 2015
14 Oct 2015
publication
Generation of long, fully modified, and serum-resistant oligonucleotides by rolling circle amplification
Read more14 Sep 2015
01 May 2015
publication
Probing the effect of minor groove interactions on the catalytic efficiency of DNAzymes 8-17 and 10-23
Read more25 Jan 2015
publication
A method for selecting modified DNAzymes without the use of modified DNA as a template in PCR
Read more17 Jul 2014
publication
Synthesis and biochemical characterization of tricyclothymidine triphosphate (tc-TTP)
Read more03 Apr 2014
02 Jul 2013
publication
Deoxynucleoside triphosphates bearing histamine, carboxylic acid, and hydroxyl residues–synthesis and biochemical characterization
Read more13 Mar 2013
publication
Toward the combinatorial selection of chemically modified DNAzyme RNase A mimics active against all-RNA substrates
Read more15 Nov 2012
publication
Nucleoside triphosphates–building blocks for the modification of nucleic acids
Read more20 Sep 2012
publication
Synthesis of deoxynucleoside triphosphates that include proline, urea, or sulfonamide groups and their polymerase incorporation into DNA
Read more05 May 2012
13 Jun 2011
10 Feb 2011
publication
Protein-inspired modified DNAzymes: dramatic effects of shortening side-chain length of 8-imidazolyl modified deoxyadenosines in selecting RNaseA mimicking DNAzymes
Read more01 Jan 2011
17 Aug 2009
publication
A DNAzyme with three protein-like functional groups: enhancing catalytic efficiency of M2+-independent RNA cleavage
Read more19 Jan 2009
publication
A self-cleaving DNA enzyme modified with amines, guanidines and imidazoles operates independently of divalent metal cations (M2+)
Read more01 Jan 2008
01 Jan 2008
15 Apr 2005
publication
Fluorinated olefinic peptide nucleic acid: synthesis and pairing properties with complementary DNA
Read more29 May 2003
publication
Synthesis and incorporation into PNA of fluorinated olefinic PNA (F-OPA) monomers
Read more01 May 2003
08 Jun 2000
publication