Ligne de temps

Marcel Hollenstein
Responsable de Structure
01 Sep 2021
publication

A ruthenium-oligonucleotide bioconjugated photosensitizing aptamer for cancer cell specific photodynamic therapy

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07 Jul 2021
publication

Towards the enzymatic synthesis of phosphorothioate containing LNA oligonucleotides

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29 Apr 2021
publication

Enzymatic construction of metal-mediated nucleic acid base pairs

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27 Apr 2021
publication

Recent progress in non-native nucleic acid modifications

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14 Apr 2021
publication

Stealth Fluorescence Labeling for Live Microscopy Imaging of mRNA Delivery

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22 Oct 2020
publication

Enzymatic Formation of an Artificial Base Pair Using a Modified Purine Nucleoside Triphosphate

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16 Jul 2020
publication

Enzymatic Construction of Artificial Base Pairs: The Effect of Metal Shielding

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06 Jul 2020
publication

Evolution of abiotic cubane chemistries in a nucleic acid aptamer allows selective recognition of a malaria biomarker.

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15 May 2020
publication

Orthogonal Genetic Systems

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07 May 2020
publication

Enzymatic synthesis of biphenyl-DNA oligonucleotides

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20 Mar 2020
project

Field Test for Rabies Diagnostic (FiTeRaD)

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19 Mar 2020
publication

Self‐Assembly of DNA and RNA Building Blocks Explored by Nitrogen‐14 NMR Crystallography: Structure and Dynamics

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25 Feb 2020
news

iGEM Pasteur Paris Team 2019 – DIANE Project

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30 Jan 2020
publication

Ruthenium-initiated polymerization of lactide: a route to remarkable cellular uptake for photodynamic therapy of cancer.

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30 Jan 2020
publication

Ruthenium-initiated polymerization of lactide: a route to remarkable cellular uptake for photodynamic therapy of cancer

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23 Dec 2019
publication

Enzymatic Formation of an Artificial Base Pair Using a Modified Adenine Nucleoside Triphosphate

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13 Dec 2019
publication

On the Enzymatic Formation of Metal Base Pairs with Thiolated and pKa-Perturbed Nucleotides

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09 Sep 2019
event

Department of Structural biology and chemistry seminar: Dr; David M. Perrin, Selection of RNaseA-mimicking DNAzymes with amines, imidazoles, and guanidines that cleave RNA: from unnatural aptamer selections unto to the origin of life

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04 Sep 2019
event

Department of Structural Biology and Chemistry: David M. Perrin, Selection of RNaseA-mimicking DNAzymes with amines, imidazoles, and guanidines that cleave RNA: from unnatural aptamer selections unto to the origin of life

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19 Aug 2019
publication

Compatibility of 5-ethynyl-2’F-ANA UTP with in vitro selection for the generation of base-modified, nuclease resistant aptamers

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14 Jul 2019
publication

Nucleic acid enzymes based on functionalized nucleosides

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17 May 2019
publication

Synthesis and Enzymatic Characterization of Sugar-Modified Nucleoside Triphosphate Analogs

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15 May 2019
publication

Chemical methods for the modification of RNA

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29 Mar 2019
publication

Terminal Deoxynucleotidyl Transferase in the Synthesis and Modification of Nucleic Acids

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02 Feb 2019
publication

Towards the enzymatic formation of artificial metal base pairs with a carboxy-imidazole-modified nucleotide

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02 Jan 2019
team

Chimie Organique

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07 Dec 2018
event

Seminar Structural Biochemistry and Chemistry Department: Dr. Shana Sturla

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07 Dec 2018
event

Seminar of the Structural Biology and Chemistry department: Mélanie Etheve-Quelquejeu

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21 Oct 2018
publication

Incorporation of a minimal nucleotide into DNA

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22 Aug 2018
project

Expansion of the genetic alphabet with metal base pairs

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22 Aug 2018
project

Therapeutic tools based on nucleic acids

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23 Jul 2018
publication

Shaping Rolling Circle Amplification Products into DNA Nanoparticles by Incorporation of Modified Nucleotides and Their Application to In Vitro and In Vivo Delivery of a Photosensitizer

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23 Jul 2018
publication

Tetrahedral DNAzymes for enhanced intracellular gene-silencing activity

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06 Apr 2018
event

Seminar of the Department of Structural Biology and Chemistry

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04 Apr 2018
publication

Aptamer chemistry

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24 Jan 2018
publication

DNA Synthesis by Primer Exchange Reaction Cascades

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19 Jun 2017
publication

Enzymatic Synthesis of 7’,5’-Bicyclo-DNA Oligonucleotides

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01 May 2017
publication

On the enzymatic incorporation of an imidazole nucleotide into DNA

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17 Mar 2017
project

Synthesis of chemically modified nucleoside triphosphates

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04 Feb 2017
publication

New synthetic route to ethynyl-dUTP: A means to avoid formation of acetyl and chloro vinyl base-modified triphosphates that could poison SELEX experiments

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05 Dec 2016
publication

Rolling circle amplification with chemically modified nucleoside triphosphates

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12 Jan 2016
team

Chimie bioorganique des acides nucléiques

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20 Nov 2015
publication

DNA Catalysis: The Chemical Repertoire of DNAzymes

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14 Oct 2015
publication

Generation of long, fully modified, and serum-resistant oligonucleotides by rolling circle amplification

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14 Sep 2015
publication

Generation of Aptamers with an Expanded Chemical Repertoire

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01 May 2015
publication

Probing the effect of minor groove interactions on the catalytic efficiency of DNAzymes 8-17 and 10-23

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25 Jan 2015
publication

A method for selecting modified DNAzymes without the use of modified DNA as a template in PCR

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17 Jul 2014
publication

Synthesis and biochemical characterization of tricyclothymidine triphosphate (tc-TTP)

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03 Apr 2014
publication

Nucleoside triphosphates–from synthesis to biochemical characterization

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02 Jul 2013
publication

Deoxynucleoside triphosphates bearing histamine, carboxylic acid, and hydroxyl residues–synthesis and biochemical characterization

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13 Mar 2013
publication

Toward the combinatorial selection of chemically modified DNAzyme RNase A mimics active against all-RNA substrates

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15 Nov 2012
publication

Nucleoside triphosphates–building blocks for the modification of nucleic acids

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20 Sep 2012
publication

Synthesis of deoxynucleoside triphosphates that include proline, urea, or sulfonamide groups and their polymerase incorporation into DNA

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05 May 2012
publication

Polymerase incorporation of pyrene-nucleoside triphosphates

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13 Jun 2011
publication

A divalent metal-dependent self-cleaving DNAzyme with a tyrosine side chain

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10 Feb 2011
publication

Protein-inspired modified DNAzymes: dramatic effects of shortening side-chain length of 8-imidazolyl modified deoxyadenosines in selecting RNaseA mimicking DNAzymes

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01 Jan 2011
publication

Expanding the catalytic repertoire of DNAzymes by modified nucleosides

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17 Aug 2009
publication

A DNAzyme with three protein-like functional groups: enhancing catalytic efficiency of M2+-independent RNA cleavage

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19 Jan 2009
publication

A self-cleaving DNA enzyme modified with amines, guanidines and imidazoles operates independently of divalent metal cations (M2+)

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01 Jan 2008
publication

In vitro selection of a DNAzyme with three modified nucleotides

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01 Jan 2008
publication

A highly selective DNAzyme sensor for mercuric ions

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15 Apr 2005
publication

Fluorinated olefinic peptide nucleic acid: synthesis and pairing properties with complementary DNA

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29 May 2003
publication

Synthesis and incorporation into PNA of fluorinated olefinic PNA (F-OPA) monomers

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01 May 2003
publication

Fluorinated peptide nucleic acid

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08 Jun 2000
publication

Diborane nitrogenrammonia plasma chemistry investigated by infrared absorption spectroscopy

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