Timeline

Paola Minoprio
Head of Structure
14 Feb 2019
project

Private: PTR 403 – Generation and validation of innovative tools for 2D- and 3D-real time imaging of trypanosomatid parasites in their mammalian hosts

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12 Sep 2015
project

T. vivax-Diag

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12 Sep 2015
project

ChagasDiag

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12 Aug 2015
publication

Global Gene Expression Profiling through the Complete Life Cycle of Trypanosoma vivax

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02 Jul 2015
project

Chagas

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11 May 2015
team

Trypanosomatids Infectious Processes

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12 Apr 2015
publication

Phylogenetic and syntenic data support a single horizontal transference to a Trypanosoma ancestor of a prokaryotic proline racemase implicated in parasite evasion from host defences

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25 Jul 2013
publication

In vivo imaging of trypanosomes for a better assessment of host-parasite relationships and drug efficacy

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16 Apr 2013
publication

Combined approaches for drug design points the way to novel proline racemase inhibitor candidates to fight Chagas’ disease

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03 Jan 2013
publication

Non-invasive in vivo study of the Trypanosoma vivax infectious process consolidates the brain commitment in late infections

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27 Dec 2011
publication

Genetic engineering of Trypanosoma (Dutonella) vivax and in vitro differentiation under axenic conditions

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13 Sep 2011
publication

Drug discovery targeting amino acid racemases

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10 Aug 2010
publication

Trypanosoma vivax infections: pushing ahead with mouse models for the study of Nagana. II. Immunobiological dysfunctions

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10 Aug 2010
publication

Trypanosoma vivax infections: pushing ahead with mouse models for the study of Nagana. I. Parasitological, hematological and pathological parameters

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01 Jun 2010
publication

Intravenous immunoglobulin increases survival time in the acute phase of experimental Chagas disease

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01 Dec 2009
publication

Inhibition of Trypanosoma cruzi proline racemase affects host-parasite interactions and the outcome of in vitro infection

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01 Dec 2009
publication

Inhibition of Trypanosoma cruzi proline racemase affects host-parasite interactions and the outcome of in vitro infection

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01 Jul 2009
publication

Proline racemases: insights into Trypanosoma cruzi peptides containing D-proline

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13 Feb 2009
publication

Proline racemases are conserved mitogens: characterization of a Trypanosoma vivax proline racemase

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12 Sep 2007
publication

Molecular and structural discrimination of proline racemase and hydroxyproline-2-epimerase from nosocomial and bacterial pathogens

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30 Jan 2006
publication

Crystal structure, catalytic mechanism, and mitogenic properties of Trypanosoma cruzi proline racemase

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01 Oct 2005
publication

Trypanosoma cruzi proline racemases are involved in parasite differentiation and infectivity

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01 May 2003
publication

Biochemical characterization of proline racemases from the human protozoan parasite Trypanosoma cruzi and definition of putative protein signatures

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01 Oct 2002
publication

Immunotherapy of Trypanosoma cruzi infections

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01 Sep 2002
publication

Increased Trypanosoma cruzi invasion and heart fibrosis associated with high transforming growth factor beta levels in mice deficient in alpha(2)-macroglobulin

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01 May 2001
publication

Parasite polyclonal activators: new targets for vaccination approaches?

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01 Feb 2001
publication

Significant association between the skewed natural antibody repertoire of Xid mice and resistance to Trypanosoma cruzi infection

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01 Aug 2000
publication

A B-cell mitogen from a pathogenic trypanosome is a eukaryotic proline racemase

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01 Feb 2000
publication

Lymphocyte polyclonal activation: a pitfall for vaccine design against infectious agents

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01 Feb 2000
publication

Changes in the cytokine profile of lupus-prone mice (NZB/NZW)F1 induced by Plasmodium chabaudi and their implications in the reversal of clinical symptoms

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01 Dec 1999
publication

Theileria annulata in CD5(+) macrophages and B1 B cells

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01 Aug 1999
publication

A Trypanosoma cruzi alkaline antigen induces polyclonal B-cell activation of normal murine spleen cells by T-cell-independent, BCR-directed stimulation

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01 Mar 1999
publication

Partial protection of mice against Trypanosoma cruzi after immunizing with the TcY 72 antigenic preparation

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01 Feb 1999
publication

X-linked immunodeficiency affects the outcome of Schistosoma mansoni infection in the murine model

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01 Jun 1998
publication

A 24,000 MW Trypanosoma cruzi antigen is a B-cell activator

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01 Feb 1997
publication

Evidence for a protective role of tumor necrosis factor in the acute phase of Trypanosoma cruzi infection in mice

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01 Aug 1996
publication

V beta 6-bearing T cells are involved in resistance to Trypanosoma cruzi infection in XID mice

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01 Jun 1996
publication

Murine acariasis. II. Immunological dysfunction and evidence for chronic activation of Th-2 lymphocytes

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01 Mar 1996
publication

The influence of T cell subsets on Trypanosoma cruzi multiplication in different organs

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01 Mar 1996
publication

Ig-isotype patterns of primary and secondary B cell responses to Plasmodium chabaudi chabaudi correlate with IFN-gamma and IL-4 cytokine production with CD45RB expression by CD4+ spleen cells

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01 Feb 1996
publication

Intranasal inoculation of Bordetella bronchiseptica in mice induces long-lasting antibody and T-cell mediated immune responses

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01 Jan 1996
publication

Chagas’ disease is attenuated in mice lacking gamma delta T cells

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01 Aug 1995
publication

The relative impact of bacterial virulence and host genetic background on cytokine expression during Mycobacterium avium infection of mice

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01 May 1995
publication

Defects in the regulation of anti-DNA antibody production in aged lupus-prone (NZB x NZW)F1 mice: analysis of T-cell lymphokine synthesis

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01 Mar 1995
publication

In vivo evidence for a non-T cell origin of interleukin-5

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01 Sep 1994
publication

Role of gamma interferon and tumor necrosis factor alpha during T-cell-independent and -dependent phases of Mycobacterium avium infection

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16 Aug 1994
publication

Murine AIDS protects mice against experimental cerebral malaria: down-regulation by interleukin 10 of a T-helper type 1 CD4+ cell-mediated pathology

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01 Jul 1994
publication

Role of interleukin-6 in the induction of protective T cells during mycobacterial infections in mice

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01 Jul 1994
publication

Increase of B-lymphocyte number and activity during experimental murine schistosomiasis mansoni

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01 Mar 1994
publication

Skewed V beta TCR repertoire of CD8+ T cells in murine Trypanosoma cruzi infection

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01 Jan 1994
publication

Endogenous IL-10 and IFN-gamma production controls thymic cell proliferation in mice acutely infected by Trypanosoma cruzi

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15 Oct 1993
publication

Xid-associated resistance to experimental Chagas’ disease is IFN-gamma dependent

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01 May 1992
publication

CD5 B cells. Potential role in the (auto)immune responses to Trypanosoma cruzi infection

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01 Jan 1992
publication

V-region-related and -unrelated immunosuppression accompanying infections

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01 May 1991
publication

Xid immunodeficiency imparts increased parasite clearance and resistance to pathology in experimental Chagas’ disease

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01 Feb 1991
publication

Chagas’ disease: Trypanosoma cruzi vs. the host immune system

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01 Feb 1991
publication

Is TNF alpha involved in early susceptibility of Trypanosoma cruzi-infected C3H/He mice?

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01 Feb 1991
publication

Chagas’ disease: CD5 B-cell-dependent Th2 pathology?

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01 Dec 1989
publication

Immunobiology of murine T. cruzi infection: the predominance of parasite-nonspecific responses and the activation of TCRI T cells

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01 Nov 1989
publication

Further phenotypic characterization of target cells for bovine leukemia virus experimental infection in sheep

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01 Jul 1989
publication

Susceptible mice present higher macrophage activation than resistant mice during infections with myotropic strains of Trypanosoma cruzi

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01 Jun 1989
publication

Indiscriminate representation of VH-gene families in the murine B lymphocyte responses to Trypanosoma cruzi

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01 Jan 1989
publication

Preferential expansion of Ly-1 B and CD4- CD8- T cells in the polyclonal lymphocyte responses to murine T. cruzi infection

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01 Nov 1988
publication

Lymphocyte subpopulations and clonal repertoires participate in immune response to acute T. cruzi infection

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01 Nov 1988
publication

Depletion of L3T4+ T lymphocytes during acute Trypanosoma cruzi infection abolish macrophage and B lymphocyte activation but not tissue inflammatory reaction

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01 Nov 1988
publication

Most B cells in acute Trypanosoma cruzi infection lack parasite specificity

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01 May 1988
publication

Parasitic load increases and myocardial inflammation decreases in Trypanosoma cruzi-infected mice after inactivation of helper T cells

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15 Jul 1987
publication

Suppression of polyclonal antibody production in Trypanosoma cruzi-infected mice by treatment with anti-L3T4 antibodies

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01 Dec 1986
publication

Polyclonal lymphocyte responses to murine Trypanosoma cruzi infection. II. Cytotoxic T lymphocytes

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01 Dec 1986
publication

Polyclonal lymphocyte responses to murine Trypanosoma cruzi infection. I. Quantitation of both T- and B-cell responses

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01 Jul 1986
publication

Persistence of polyclonal B cell activation with undetectable parasitemia in late stages of experimental Chagas’ disease

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01 Jan 1980
publication

In vitro study of immunological events in human and experimental schistosomiasis: relationships between cytotoxic antibodies and circulating Schistosoma antigens

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