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© Research
Publication : Parasite immunology

Intravenous immunoglobulin increases survival time in the acute phase of experimental Chagas disease

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Parasite immunology - 01 Jun 2010

Olivieri BP, Vasconcellos R, Nóbrega A, Minoprio P, Kaveri SV, Araújo-Jorge TC

Link to Pubmed [PMID] – 20500678

Parasite Immunol. 2010 Jun;32(6):464-9

Chagas disease induced by Trypanosoma cruzi (Tc) infection is an important cause of mortality and morbidity affecting the cardiovascular system for which presently available therapies are insufficient and largely inadequate. Intravenous immunoglobulin (IVIg) is a therapeutic preparation containing normal polyspecific IgG obtained from plasma pools of several thousand healthy donors and is used in several autoimmune, inflammatory and infectious diseases. In the study of heart from mice chronically infected with Tc, we observed that IVIg restores type 1 atrioventricular block or bradycardia. In the present study, we investigated the effects of IVIg in acute Tc infection. Intravenous immunoglobulin administration after the first week of infection was associated with an increase in survival time. Taken together, results observed in the chronic and in the acute phase associate IVIg treatment with a favourable outcome in T. cruzi infection.

http://www.ncbi.nlm.nih.gov/pubmed/20500678