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© Research
Publication : International immunology

Xid immunodeficiency imparts increased parasite clearance and resistance to pathology in experimental Chagas’ disease

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in International immunology - 01 May 1991

Minoprio P, Coutinho A, Spinella S, Hontebeyrie-Joskowicz M

Link to Pubmed [PMID] – 1911532

Int. Immunol. 1991 May;3(5):427-33

Infection of several mouse strains with Trypanosoma cruzi stimulates high levels of T and B lymphocyte activities which persist during the chronic phase and is followed by specific immunosuppression and severe autoimmune pathology. Infected BALB.Xid mice carrying an X-linked mutation and lacking CD5 B cells, display poor B cell responses to T. cruzi infection, accompanied by low levels of specific and non-specific immunoglobulins in the serum. However, these animals control parasitemia, do not show the wasting observed in BALB/c mice, and develop almost no pathology early in the chronic phase. The infection of (BALB.Xid female x BALB/c male) F1 animals shows that immunodefective males behave like Xid animals in contrast to females which respond as normal BALB/c mice. These results indicate that the Xid locus controls lymphocyte responses, parasite clearance and pathology in experimental Chagas’ disease.

http://www.ncbi.nlm.nih.gov/pubmed/1911532