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© Research
Laboratory

Trypanosomatids Infectious Processes

Department of Global Health

About

The Trypanosomatids Infectious Processes team studies experimental models of Chagas’ disease and Animal Sleeping sickness, two of the ”most neglected diseases” that afflict the poor and powerless in developing regions of sub-Saharan Africa, Asia and the Americas. Together they cause an estimated 500,000 to 1 million deaths annually. Chagas’ disease, the third largest disease burden in Latin America, is cause by Trypanosoma cruzi. It affects at least 15 million people and 100 million people are at risk. Human and animal sleeping sickness (Nagana) trypanosomosis is a major public health concern in 35 sub-Saharan countries. The livestock challenge, which is mainly caused by Trypanosoma vivax, causes about 3 million cattle deaths annually, has a severe impact on African’s agriculture, and was recently introduced into South America and Mauritius.The team has recently drawn its attention to other protozoan parasites of the trypanosomatid family which are equally triggering “neglected diseases” : Leishmania donovani/L. infantum and L. major, responsible respectively for Visceral and Cutaneous Leishmaniasis. Leishmaniasis threaten about 350 million people in 98 countries or territories around the world, most particularly in Asia, Eastern and Northern Africa and the Mediterranean and Amazonian bassins.  No vaccines have yet been developed against these seriously disabling or life-threatening illnesses.

Tcruzi Tvivax Leish

 Our projects address fundamental questions centered on the better understanding of the host immune system disturbances triggered by Trypanosomatids infectious processes. For that the team uses multidisciplinary approaches to identify and validate molecules that play a role in virulence, parasite escape and persistance. Most particularly, the Trypanosomatids Infectious Processes team aims to identify critical molecules for parasite metabolic pathways that could be involved in the acquisition of infectivity, in the deregulation of the immune system of the host or playing a role in the pathogenesis. The team has developed genetic parasitic outfits for validating potential therapeutic and targets and diagnostic tools using in vitro and in vivo real-time imaging. Our general goals are the identification of specific biomarkers for late, chronic, stages of those diseases and to develop new molecules that could be at the origin of innovative therapeutic and diagnostic approaches.

The Laboratory of Trypanosomatids Infectious Processes holds a “Chaire Franco Brésilienne PASTEUR/USP” together with the University of Sao Paulo and is a Host Laboratory of the Graduate School “Complexity of the Living”, Université Pierre et Marie Curie, Paris 6.

Former Members

2000
2000
Name
Position
2015
2018
Jocelyne Alexandre
Lab assistant
2015
2018
Marcelo Alves Ferreira
Group Leader
2015
2018
Delphine Autheman
Post-doc
2015
2018
Jean-Christophe Barale
Group Leader
2015
2018
Asma Ben Meriem
PhD Student
2015
2018
Armand Berneman
Research Engineer
2015
2018
Julienne Blonbou
2015
2018
Stéphanie Bosne
Post-doc
2015
2018
Anabela Cordeiro da Silva
Head of Structure
2015
2018
Nathalie Chamond
Group Leader
2015
2018
Marcia Cury El Cheikh
Group Leader
2015
2018
Simon D’Archivio
Post-doc
2015
2018
Wim Mauritis Degrave
Head of Structure
2015
2018
Poliana Deolindo
Post-doc
2015
2018
Paula Ferreira
Head of Structure
2015
2018
Nicolas Gangneux
Technician
2015
2018
Sophie Goyard
2015
2018
Maira Goytia
Project Manager
2015
2018
Christophe Grégoire
Group Leader
2015
2018
Adriana Gruppi
Head of Structure
2015
2018
Muneaki Hashimoto
Permanent Researcher
2015
2018
Cristina Henriques
2015
2018
Hervé Lecoeur
Research Engineer
2015
2018
Carolina Montes
Group Leader
2015
2018
Patricia Maria Lourenço Dutra
Head of Structure
2015
2018
Daniel Martel
PhD Student
2015
2018
Bernardo Reina San Martin
Head of Structure
2015
2018
Eline Rouault
Technician
2015
2018
Eduardo Cesar Santos Lima
Director of Department
2015
2018
Jennifer da Silva
PhD Student
2015
2018
Nancy Starobinas
Group Leader
2015
2018
Brigitte Thierry
2015
2018
Françoise Thouron
2015
2018
Mariana C. Waghabi
Project Manager
2015
2018
Rafael Muniz Guedes
Post-doc
2015
2018
Carla Monadeli Rodrigues
PhD Student
2015
2018
Marine Leroux
Graduate Student
2015
2018
Laurence Boutout
Administrative Staff
2015
2018
Marie-Jesus Rojas
Technician
2015
2018
Martine Belin
Administrative Staff
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Contact

Phone: +33.1.4568.8615
Email: paola.minoprio@pasteur.fr

Address
25-28 Rue du Docteur Roux
75015, Paris
France