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© Research
Publication : Annales de l'Institut Pasteur. Immunology

Parasitic load increases and myocardial inflammation decreases in Trypanosoma cruzi-infected mice after inactivation of helper T cells

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Annales de l'Institut Pasteur. Immunology - 01 May 1988

Russo M, Starobinas N, Minoprio P, Coutinho A, Hontebeyrie-Joskowicz M

Link to Pubmed [PMID] – 2901844

Ann. Inst. Pasteur Immunol. 1988 May-Jun;139(3):225-36

In order to characterize the role played by CD4+ T lymphocytes in the immunopathology of acute Trypanosoma cruzi infection, we compared the numbers of blood and tissue parasites and the heart inflammatory reaction in normal and anti-CD4 antibody-treated C3H mice. Treatment of mice with anti-CD4 mAb during acute infection markedly inhibited T-helper-cell-dependent activities, as measured by peritoneal macrophage activation and immunoglobulin secretion by splenic B lymphocytes. After in vivo inactivation of helper T cells, the number of blood and tissue parasites significantly increased, while the inflammatory cellular infiltrates of heart muscles diminished. Our results indicate that CD4+ T lymphocytes play a dual role in the immunopathology of acute experimental Chagas’ disease.

http://www.ncbi.nlm.nih.gov/pubmed/2901844