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© Research
Publication : Memórias do Instituto Oswaldo Cruz

Partial protection of mice against Trypanosoma cruzi after immunizing with the TcY 72 antigenic preparation

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Memórias do Instituto Oswaldo Cruz - 01 Mar 1999

Gomes YM, Abath FG, Nakazawa M, Minoprio P, Vouldoukis I, Monjour L

Link to Pubmed [PMID] – 10224522

Mem. Inst. Oswaldo Cruz 1999 Mar-Apr;94(2):167-72

A 72 kDa Trypanosoma cruzi glycoprotein recognized by the 164C11 monoclonal antibody (IgM isotype) was purified by preparative electrophoresis. The antigenic preparation obtained, named TcY 72, was used to immunize C57Bl/10 mice. The following results were observed after immunization: (1) induction of higher titres of IgG than IgM antibodies, as evaluated by indirect immunofluorescence; (2) significant DTH after injection of epimastigotes in mice footpads; (3) peak parasitemia in immunized mice was significantly reduced and animals were negative by 13 days post-infection, although the mice still succumb to infection; (4) the phenotypic analysis of spleen cell populations showed a decrease in the CD4/CD8 ratio in immunized mice. Taken as a whole, these findings indicate that TcY 72 is immunogenic and potentially important for protective immunity.

http://www.ncbi.nlm.nih.gov/pubmed/10224522