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© Research
Publication : Parasite immunology

In vitro study of immunological events in human and experimental schistosomiasis: relationships between cytotoxic antibodies and circulating Schistosoma antigens

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Parasite immunology - 01 Jan 1980

Capron M, Carlier Y, Nzeyimana H, Minoprio P, Santoro F, Sellin B, Capron A

Link to Pubmed [PMID] – 7413247

Parasite Immunol. 1980;2(3):223-35

Complement-dependent cytotoxic antibodies were found in 54% of Schistosoma mansoni infected patients from Burundi and in 69 to 78% of Schistosoma mansoni ninfected Brazilian patients. The levels of cytotoxic Ab were not statistically different in sera from infected mothers and from their newborn children, suggesting a transfer through the placenta. A sandwich radioimmunoassay (SRIA) and the Radioimmunoprecipitaion-PEG assay (RIPEGA) technique were used in order to detect respectively total schistosome circulating soluble antigens (CSA) and schistosome antigen ‘4’ in sera from infected patients. An inverse relationship was found between the presence of cytotoxic Ab and both total CSA and antigen ‘4’. The cytotoxic Ab and total CSA levels were followed in five Erythrocebus patas monkeys for 30 weeks after Schistosoma mansoni infection. As in human schistosomiasis the presence of cytotoxic Ab was found to be inversely correlated with the presence of total CAS. The blocking role of Schistosoma mansoni antigens in a complexed form was suggested by the inhibitory effect of the ultracentrifugation pellet of infected human serum on the cytotoxic activity. Moreover, the CSA absorption of infected monkey serum by passage through an anti-CSA immunosorbent significantly increased the cytotoxic activity. Possible mechanisms for the inhibitory role of circulating immune complexes on complement-dependent cytotoxic activity are discussed.

http://www.ncbi.nlm.nih.gov/pubmed/7413247