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© Research
Publication : International immunology

Skewed V beta TCR repertoire of CD8+ T cells in murine Trypanosoma cruzi infection

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in International immunology - 01 Mar 1994

Leite-de-Moraes MC, Coutinho A, Hontebeyrie-Joskowicz M, Minoprio P, Eisen H, Bandeira A

Link to Pubmed [PMID] – 8186190

Int. Immunol. 1994 Mar;6(3):387-92

We have followed CD4 and CD8 TCR V beta repertoires during the acute phase of Trypanosoma cruzi infection in a resistant mouse strain (C57BL/6). No major changes were found in the V beta TCR distributions analyzed (covering roughly 40% of the TCR repertoire) in peripheral CD4 T lymphocytes, confirming the polyclonal nature of CD4 T cell responses. In contrast, in most animals, an over-representation of V beta 5 and V beta 14 TCR families was disclosed in the CD8 T cell compartment, superimposed on a predominantly polyclonal response. The preferential expansion of V beta 5+CD8+ T cells was also observed after infection of sensitive (C3H/HeJ, BALB/c) mouse strains. These observations suggest the existence of CD8 T cell-directed superantigenic activities associated with parasites.

http://www.ncbi.nlm.nih.gov/pubmed/8186190