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Immortalization of multiple cell types from transgenic mice using a transgene containing the vimentin promoter and a conditional oncogene

Eradication of hepatitis C virus RNA after alpha-interferon therapy

© Research

Publication : Proceedings of the National Academy of Sciences of the United States of America

Murine AIDS protects mice against experimental cerebral malaria: down-regulation by interleukin 10 of a T-helper type 1 CD4+ cell-mediated pathology

Team: Trypanosomatids Infectious Processes

Member: Paola Minoprio

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Published in Proceedings of the National Academy of Sciences of the United States of America - 16 Aug 1994

Eckwalanga M, Marussig M, Tavares MD, Bouanga JC, Hulier E, Pavlovitch JH, Minoprio P, Portnoï D, Rénia L, Mazier D

Link to Pubmed [PMID] – 8058763

Proc. Natl. Acad. Sci. U.S.A. 1994 Aug;91(17):8097-101

The retrovirus LP-BM5 murine leukemia virus induces murine AIDS in C57BL/6 mice that has many similarities with human AIDS; Plasmodium berghei ANKA causes experimental cerebral malaria in the same strain of mice. The outcome of malaria infection was studied in mice concurrently infected with the two pathogens. The retrovirus significantly reduced the gravity of the neurological manifestations associated with Plasmodium berghei ANKA infection. The protection against experimental cerebral malaria induced by murine AIDS increased with duration of viral infection and, hence, with the severity of the immunodeficiency. Interleukin 10, principally from splenic T cells, was shown to play a crucial role in this protection.

Published on: 16 Aug 1994