Timeline
Pierre-Jean Corringer
Head of Structure
12 Feb 2024
publication
The Nicotinic Acetylcholine Receptor and its Pentameric Homologs: Toward an Allosteric Mechanism of Signal Transduction at the Atomic Level.
Read more08 Feb 2024
01 Feb 2024
publication
Short-chain mono-carboxylates as negative modulators of allosteric transitions in Gloeobacter violaceus ligand-gated ion channel, and impact of a pre-β5 strand (Loop Ω) double mutation on crotonate, not butyrate effect.
Read more25 Sep 2023
publication
An original potentiating mechanism revealed by the cryo-EM structures of the human α7 nicotinic receptor in complex with nanobodies.
Read more25 May 2023
publication
Generation of nanobodies acting as silent and positive allosteric modulators of the α7 nicotinic acetylcholine receptor.
Read more07 Apr 2023
publication
Fumarate as positive modulator of allosteric transitions in the pentameric ligand-gated ion channel GLIC: Requirement of an intact vestibular pocket.
Read more13 Feb 2023
publication
Illumination of a progressive allosteric mechanism mediating the glycine receptor activation.
Read more27 Jan 2023
event
Department of Neuroscience seminar Vladan Lučić (Max Planck Institute of Biochemistry, Germany) – Architecture of synaptic protein assemblies by cryo-electron tomography
Read more22 Dec 2022
publication
Design of crotoxin-based peptides with potentiator activity targeting the ΔF508NBD1 Cystic Fibrosis Transmembrane Conductance Regulator.
Read more18 Nov 2022
publication
Conformational state-dependent regulation of GABAA receptor diffusion and subsynaptic domains.
Read more14 Oct 2022
publication
Lateral fenestrations in the extracellular domain of the glycine receptor contribute to the main chloride permeation pathway.
Read more30 Sep 2021
publication
Mutational analysis to explore long-range allosteric couplings involved in a pentameric channel receptor pre-activation and activation.
Read more01 Feb 2021
publication
Alterations in nicotinic receptor alpha5 subunit gene differentially impact early and later stages of cocaine addiction: a translational study in transgenic rats and patients.
Read more23 Oct 2020
14 Nov 2019
event
DPT NEUROSCIENCE – Thesis defence : Mariano GENERA – Structural and functional study of the human phosphatase PTPN3 and its interaction with oncogenic viruses.
Read more08 Oct 2019
08 Oct 2019
08 Oct 2019
02 Sep 2019
event
PhD defense – Solène Lefebvre – “Applications de la fluorescence pour la caractérisation structurale et dynamique d’intermédiaires conformationnels des récepteurs-canaux pentamériques” – Department of Neuroscience
Read more29 Mar 2019
publication
Large Intracellular Domain-Dependent Effects of Positive Allosteric Modulators on Glycine Receptors
Read more24 Jan 2019
event
Neuroscience Seminar Series : Structure-guided design of synthetic connectors for synaptic repair.
Read more12 Dec 2018
publication
Electrostatics, proton sensor, and networks governing the gating transition in GLIC, a proton-gated pentameric ion channel
Read more31 Oct 2018
04 Sep 2018
15 May 2018
publication
The dual-gate model for pentameric ligand-gated ion channels activation and desensitization.
Read more09 Apr 2018
publication
Crystal structures of a pentameric ion channel gated by alkaline pH show a widely open pore and identify a cavity for modulation
Read more27 Feb 2018
project
Toxins and nanobodies as subtype-specific ligands and allosteric modulators of nicotinic acetylcholine receptors (PTR Nicobinder)
Read more27 Feb 2018
project
Discovery of allosteric modulators specifically targeting α5-containing nAChRs. (ANR-Nicofive)
Read more24 Jan 2018
27 Dec 2017
publication
Full mutational mapping of titratable residues helps to identify proton-sensors involved in the control of channel gating in the Gloeobacter violaceus pentameric ligand-gated ion channel
Read more30 Nov 2017
publication
Interaction of Synthetic Human SLURP-1 with the Nicotinic Acetylcholine Receptors
Read more14 Apr 2017
15 Jul 2016
publication
Interaction of three-finger proteins from snake venoms and from mammalian brain with the cys-loop receptors and their models
Read more06 Jun 2016
publication
Phosphorylation state-dependent modulation of spinal glycine receptors alleviates inflammatory pain
Read more27 May 2016
publication
Rattlesnake Phospholipase A2 Increases CFTR-Chloride Channel Current and Corrects ∆F508CFTR Dysfunction: Impact in Cystic Fibrosis
Read more04 May 2016
publication
Emerging Molecular Mechanisms of Signal Transduction in Pentameric Ligand-Gated Ion Channels
Read more05 Feb 2016
publication
Neurotoxic phospholipase A2 from rattlesnake as a new ligand and new regulator of prokaryotic receptor GLIC (proton-gated ion channel from G. violaceus)
Read more14 May 2015
publication
Ethanol Modulation is Quantitatively Determined by the Transmembrane Domain of Human α1 Glycine Receptors
Read more03 Mar 2015
publication
Allosteric and hyperekplexic mutant phenotypes investigated on an α1 glycine receptor transmembrane structure.
Read more21 Sep 2014
23 Dec 2013
publication
Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation
Read more01 Oct 2013
publication
Intermediate closed state for glycine receptor function revealed by cysteine cross-linking
Read more04 Jun 2013
publication
Identification of cinnamic acid derivatives as novel antagonists of the prokaryotic proton-gated ion channel GLIC
Read more05 Mar 2013
publication
Structural sensitivity of a prokaryotic pentameric ligand-gated ion channel to its membrane environment
Read more12 Feb 2013
publication
Structural basis for ion permeation mechanism in pentameric ligand-gated ion channels
Read more03 Oct 2012
publication
Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines
Read more06 Jun 2012
publication
Structure and pharmacology of pentameric receptor channels: from bacteria to brain
Read more13 May 2012
publication
A locally closed conformation of a bacterial pentameric proton-gated ion channel
Read more23 Dec 2011
20 Oct 2011
publication
Unravelling the conformational plasticity of the extracellular domain of a prokaryotic nAChR homologue in solution by NMR
Read more05 Jul 2011
publication
Functional prokaryotic-eukaryotic chimera from the pentameric ligand-gated ion channel family
Read more05 Jul 2011
publication
Structural basis for alcohol modulation of a pentameric ligand-gated ion channel
Read more29 Jun 2011
publication
Discrimination of agonists versus antagonists of nicotinic ligands based on docking onto AChBP structures
Read more20 Jan 2011
publication
X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel
Read more14 Aug 2010
publication
3D structure and allosteric modulation of the transmembrane domain of pentameric ligand-gated ion channels
Read more22 Mar 2010
publication
One-microsecond molecular dynamics simulation of channel gating in a nicotinic receptor homologue
Read more07 Dec 2009
publication
Atomic structure and dynamics of pentameric ligand-gated ion channels: new insight from bacterial homologues
Read more21 Nov 2009
13 Nov 2009
publication
Crystal structure of the extracellular domain of a bacterial ligand-gated ion channel
Read more01 Sep 2009
publication
Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system
Read more05 Nov 2008
publication
X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation
Read more08 Oct 2008
publication
Regional differential effects of chronic nicotine on brain alpha 4-containing and alpha 6-containing receptors
Read more10 Dec 2006
publication
A prokaryotic proton-gated ion channel from the nicotinic acetylcholine receptor family
Read more31 Oct 2006
publication
Implications of the quaternary twist allosteric model for the physiology and pathology of nicotinic acetylcholine receptors
Read more03 Feb 2006
publication
Nicotine enhances intracellular nicotinic receptor maturation: a novel mechanism of neural plasticity?
Read more19 May 2005
publication
Nicotine upregulates its own receptors through enhanced intracellular maturation
Read more01 Apr 2005
publication
Normal mode analysis suggests a quaternary twist model for the nicotinic receptor gating mechanism
Read more05 Feb 2004
publication
An extracellular protein microdomain controls up-regulation of neuronal nicotinic acetylcholine receptors by nicotine
Read more01 Feb 2004
publication
Distinct subcellular targeting of fluorescent nicotinic alpha 3 beta 4 and serotoninergic 5-HT3A receptors in hippocampal neurons
Read more01 May 2003
publication
An H-bond between two residues from different loops of the acetylcholine binding site contributes to the activation mechanism of nicotinic receptors
Read more01 Dec 2002
publication
The diversity of subunit composition in nAChRs: evolutionary origins, physiologic and pharmacologic consequences
Read more25 Sep 2002
publication
Allosteric transitions of Torpedo acetylcholine receptor in lipids, detergent and amphipols: molecular interactions vs. physical constraints
Read more26 Feb 2002
publication
Experimentally based model of a complex between a snake toxin and the alpha 7 nicotinic receptor
Read more13 Mar 2001
publication
A method for soluble overexpression of the alpha7 nicotinic acetylcholine receptor extracellular domain
Read more20 Feb 2001
publication
Desensitization of neuronal nicotinic acetylcholine receptors conferred by N-terminal segments of the beta 2 subunit
Read more22 Sep 2000
publication
Molecular determinants by which a long chain toxin from snake venom interacts with the neuronal alpha 7-nicotinic acetylcholine receptor
Read more13 Jun 2000
publication
Structural differences in the two agonist binding sites of the Torpedo nicotinic acetylcholine receptor revealed by time-resolved fluorescence spectroscopy
Read more30 Mar 2000
publication
Molecular characterization of the specificity of interactions of various neurotoxins on two distinct nicotinic acetylcholine receptors
Read more01 Jan 2000
01 May 1999
publication
Improved secondary structure predictions for a nicotinic receptor subunit: incorporation of solvent accessibility and experimental data into a two-dimensional representation
Read more01 Apr 1999
publication
Mutational analysis of the charge selectivity filter of the alpha7 nicotinic acetylcholine receptor
Read more01 May 1998
publication
Brain nicotinic receptors: structure and regulation, role in learning and reinforcement
Read more01 Apr 1998
publication
Functional determinants by which snake and cone snail toxins block the alpha 7 neuronal nicotinic acetylcholine receptors
Read more01 Feb 1998
publication
Ivermectin: a positive allosteric effector of the alpha7 neuronal nicotinic acetylcholine receptor
Read more15 Jan 1998
publication
Critical elements determining diversity in agonist binding and desensitization of neuronal nicotinic acetylcholine receptors
Read more10 Nov 1997
publication
Paradoxical allosteric effects of competitive inhibitors on neuronal alpha7 nicotinic receptor mutants
Read more01 Nov 1996
publication
Identification of calcium binding sites that regulate potentiation of a neuronal nicotinic acetylcholine receptor
Read more01 Jan 1996
19 May 1995
publication
Identification of a new component of the agonist binding site of the nicotinic alpha 7 homooligomeric receptor
Read more01 Feb 1995
publication
CCKA, but not CCKB, agonists suppress the hyperlocomotion induced by endogenous enkephalins, protected from enzymatic degradation by systemic RB 101
Read more01 Jan 1993
publication
CCK-B agonist or antagonist activities of structurally hindered and peptidase-resistant Boc-CCK4 derivatives
Read more01 Nov 1992
publication
[Study of induced effects by selective CCKB agonists cholecystokinin in the nociception and behavior in rodents]
Read more01 Jun 1992
publication
[3H]pBC 264, a suitable probe for studying cholecystokinin-B receptors: binding characteristics in rodent brains and comparison with [3H]SNF 8702
Read more13 Sep 1989
publication