Timeline

Pierre-Jean Corringer
Head of Structure
02 Sep 2019
event

PhD defense – Solène Lefebvre – “Applications de la fluorescence pour la caractérisation structurale et dynamique d’intermédiaires conformationnels des récepteurs-canaux pentamériques” – Department of Neuroscience

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24 Jan 2019
event

Neuroscience Seminar Series : Structure-guided design of synthetic connectors for synaptic repair.

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09 Apr 2018
publication

Crystal structures of a pentameric ion channel gated by alkaline pH show a widely open pore and identify a cavity for modulation

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27 Feb 2018
project

Toxins and nanobodies as subtype-specific ligands and allosteric modulators of nicotinic acetylcholine receptors (PTR Nicobinder)

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27 Feb 2018
project

Discovery of allosteric modulators specifically targeting α5-containing nAChRs. (ANR-Nicofive)

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27 Feb 2018
publication

The dual-gate model for pentameric ligand-gated ion channels activation and desensitization

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24 Jan 2018
project

MECANICOC

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27 Dec 2017
publication

Full mutational mapping of titratable residues helps to identify proton-sensors involved in the control of channel gating in the Gloeobacter violaceus pentameric ligand-gated ion channel

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30 Nov 2017
publication

Interaction of Synthetic Human SLURP-1 with the Nicotinic Acetylcholine Receptors

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14 Apr 2017
event

Neuroscience – unité Récepteurs-Canaux Lab Seminar

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15 Jul 2016
publication

Interaction of three-finger proteins from snake venoms and from mammalian brain with the cys-loop receptors and their models

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06 Jun 2016
publication

Phosphorylation state-dependent modulation of spinal glycine receptors alleviates inflammatory pain

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27 May 2016
publication

Rattlesnake Phospholipase A2 Increases CFTR-Chloride Channel Current and Corrects ∆F508CFTR Dysfunction: Impact in Cystic Fibrosis

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04 May 2016
publication

Emerging Molecular Mechanisms of Signal Transduction in Pentameric Ligand-Gated Ion Channels

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05 Feb 2016
publication

Neurotoxic phospholipase A2 from rattlesnake as a new ligand and new regulator of prokaryotic receptor GLIC (proton-gated ion channel from G. violaceus)

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14 May 2015
publication

Ethanol Modulation is Quantitatively Determined by the Transmembrane Domain of Human α1 Glycine Receptors

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01 Apr 2015
publication

The nicotinic acetylcholine receptor: From molecular biology to cognition

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17 Feb 2015
publication

Allosteric and hyperekplexic mutant phenotypes investigated on an α1 glycine receptor transmembrane structure

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21 Sep 2014
team

Channel Receptors

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17 Sep 2014
department

Neuroscience

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23 Dec 2013
publication

Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation

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01 Oct 2013
publication

Intermediate closed state for glycine receptor function revealed by cysteine cross-linking

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04 Jun 2013
publication

Identification of cinnamic acid derivatives as novel antagonists of the prokaryotic proton-gated ion channel GLIC

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05 Mar 2013
publication

Structural sensitivity of a prokaryotic pentameric ligand-gated ion channel to its membrane environment

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12 Feb 2013
publication

Structural basis for ion permeation mechanism in pentameric ligand-gated ion channels

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03 Oct 2012
publication

Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines

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06 Jun 2012
publication

Structure and pharmacology of pentameric receptor channels: from bacteria to brain

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13 May 2012
publication

A locally closed conformation of a bacterial pentameric proton-gated ion channel

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23 Dec 2011
publication

[X-ray structures of general anesthetics bound to their molecular targets]

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20 Oct 2011
publication

Unravelling the conformational plasticity of the extracellular domain of a prokaryotic nAChR homologue in solution by NMR

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05 Jul 2011
publication

Functional prokaryotic-eukaryotic chimera from the pentameric ligand-gated ion channel family

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05 Jul 2011
publication

Structural basis for alcohol modulation of a pentameric ligand-gated ion channel

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29 Jun 2011
publication

Discrimination of agonists versus antagonists of nicotinic ligands based on docking onto AChBP structures

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20 Jan 2011
publication

X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel

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14 Aug 2010
publication

3D structure and allosteric modulation of the transmembrane domain of pentameric ligand-gated ion channels

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22 Mar 2010
publication

One-microsecond molecular dynamics simulation of channel gating in a nicotinic receptor homologue

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07 Dec 2009
publication

Atomic structure and dynamics of pentameric ligand-gated ion channels: new insight from bacterial homologues

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21 Nov 2009
publication

Anesthetic sensitivity of the Gloeobacter violaceus proton-gated ion channel

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13 Nov 2009
publication

Crystal structure of the extracellular domain of a bacterial ligand-gated ion channel

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01 Sep 2009
publication

Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system

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05 Nov 2008
publication

X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation

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08 Oct 2008
publication

Regional differential effects of chronic nicotine on brain alpha 4-containing and alpha 6-containing receptors

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10 Dec 2006
publication

A prokaryotic proton-gated ion channel from the nicotinic acetylcholine receptor family

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31 Oct 2006
publication

Implications of the quaternary twist allosteric model for the physiology and pathology of nicotinic acetylcholine receptors

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03 Feb 2006
publication

Nicotine enhances intracellular nicotinic receptor maturation: a novel mechanism of neural plasticity?

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19 May 2005
publication

Nicotine upregulates its own receptors through enhanced intracellular maturation

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01 Apr 2005
publication

Normal mode analysis suggests a quaternary twist model for the nicotinic receptor gating mechanism

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05 Feb 2004
publication

An extracellular protein microdomain controls up-regulation of neuronal nicotinic acetylcholine receptors by nicotine

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01 Feb 2004
publication

Distinct subcellular targeting of fluorescent nicotinic alpha 3 beta 4 and serotoninergic 5-HT3A receptors in hippocampal neurons

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01 May 2003
publication

An H-bond between two residues from different loops of the acetylcholine binding site contributes to the activation mechanism of nicotinic receptors

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01 Dec 2002
publication

The diversity of subunit composition in nAChRs: evolutionary origins, physiologic and pharmacologic consequences

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25 Sep 2002
publication

Allosteric transitions of Torpedo acetylcholine receptor in lipids, detergent and amphipols: molecular interactions vs. physical constraints

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26 Feb 2002
publication

Experimentally based model of a complex between a snake toxin and the alpha 7 nicotinic receptor

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13 Mar 2001
publication

A method for soluble overexpression of the alpha7 nicotinic acetylcholine receptor extracellular domain

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20 Feb 2001
publication

Desensitization of neuronal nicotinic acetylcholine receptors conferred by N-terminal segments of the beta 2 subunit

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22 Sep 2000
publication

Molecular determinants by which a long chain toxin from snake venom interacts with the neuronal alpha 7-nicotinic acetylcholine receptor

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13 Jun 2000
publication

Structural differences in the two agonist binding sites of the Torpedo nicotinic acetylcholine receptor revealed by time-resolved fluorescence spectroscopy

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30 Mar 2000
publication

Molecular characterization of the specificity of interactions of various neurotoxins on two distinct nicotinic acetylcholine receptors

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01 Jan 2000
publication

Nicotinic receptors at the amino acid level

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01 May 1999
publication

Improved secondary structure predictions for a nicotinic receptor subunit: incorporation of solvent accessibility and experimental data into a two-dimensional representation

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01 Apr 1999
publication

Mutational analysis of the charge selectivity filter of the alpha7 nicotinic acetylcholine receptor

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01 May 1998
publication

Brain nicotinic receptors: structure and regulation, role in learning and reinforcement

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01 Apr 1998
publication

Functional determinants by which snake and cone snail toxins block the alpha 7 neuronal nicotinic acetylcholine receptors

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01 Feb 1998
publication

Ivermectin: a positive allosteric effector of the alpha7 neuronal nicotinic acetylcholine receptor

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15 Jan 1998
publication

Critical elements determining diversity in agonist binding and desensitization of neuronal nicotinic acetylcholine receptors

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10 Nov 1997
publication

Paradoxical allosteric effects of competitive inhibitors on neuronal alpha7 nicotinic receptor mutants

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01 Nov 1996
publication

Identification of calcium binding sites that regulate potentiation of a neuronal nicotinic acetylcholine receptor

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01 Jan 1996
publication

Nicotinic receptors and brain plasticity

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19 May 1995
publication

Identification of a new component of the agonist binding site of the nicotinic alpha 7 homooligomeric receptor

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01 Feb 1995
publication

CCKA, but not CCKB, agonists suppress the hyperlocomotion induced by endogenous enkephalins, protected from enzymatic degradation by systemic RB 101

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01 Jan 1993
publication

CCK-B agonist or antagonist activities of structurally hindered and peptidase-resistant Boc-CCK4 derivatives

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01 Nov 1992
publication

[Study of induced effects by selective CCKB agonists cholecystokinin in the nociception and behavior in rodents]

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01 Jun 1992
publication

[3H]pBC 264, a suitable probe for studying cholecystokinin-B receptors: binding characteristics in rodent brains and comparison with [3H]SNF 8702

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13 Sep 1989
publication

[3H]pBC 264, first highly potent and very selective radioligand for CCK-B receptors

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