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© Marie Prévost, Institut Pasteur
Image of a portion of a Xenopus oocyte expressing a channel receptor.
Event

Neuroscience Seminar Series : Structure-guided design of synthetic connectors for synaptic repair.

Scientific Fields
Diseases
Organisms
Applications
Technique
Date
01
Feb 2019
Time
11:30:00
Institut Pasteur, 75015 Paris, France
Address
Building: Jacques MONOD Room: Amphi Jacques MONOD
Location
2019-02-01 11:30:00 2019-02-01 13:00:00 Europe/Paris Neuroscience Seminar Series : Structure-guided design of synthetic connectors for synaptic repair. Based on proteomics, functional and structural data, it is likely that most, if not all, neurotransmitter receptors interact with protein partners across the synaptic cleft. We have recently published the structural and functional investigation […] Institut Pasteur, 75015 Paris, France Pierre-Jean Corringer pjcorrin@pasteur.fr

About

Based on proteomics, functional and structural data, it is likely that most, if not all, neurotransmitter receptors interact with protein partners across the synaptic cleft. We have recently published the structural and functional investigation of such a complex at cerebellar synapses, which involves the post-synaptic iGluR family member GluD2, the “soluble” bridge protein Cbln1, and the pre-synaptic Neurexin 1beta. Inspired by structural work, we moved on to develop synthetic connector proteins. I will discuss such an example, and its applications.

contact : pierre-jean.corringer@pasteur.fr

Location

Building: Jacques MONOD
Room: Amphi Jacques MONOD
Address: Institut Pasteur, 75015 Paris, France