Based on proteomics, functional and structural data, it is likely that most, if not all, neurotransmitter receptors interact with protein partners across the synaptic cleft. We have recently published the structural and functional investigation of such a complex at cerebellar synapses, which involves the post-synaptic iGluR family member GluD2, the “soluble” bridge protein Cbln1, and the pre-synaptic Neurexin 1beta. Inspired by structural work, we moved on to develop synthetic connector proteins. I will discuss such an example, and its applications.
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