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© Marie Prévost, Institut Pasteur
Image of a portion of a Xenopus oocyte expressing a channel receptor.
Scientific Fields
Diseases
Organisms
Applications
Technique
Date
26
Apr 2017
Time
11:00:00
28 Rue du Dr Roux, 75015 Paris, France
Address
Building: Centre François Jacob
Location
2017-04-26 11:00:00 2017-04-26 00:00:00 Europe/Paris Neuroscience – unité Récepteurs-Canaux Lab Seminar Prof. Gergely LUKACS Department of Physiology – McGill University (Montreal, Canada) Molecular players and mechanisms of plasma membrane proteostasis in health and diseases ; cystic fibrosis and beyond. abstract Preserving the function of the […] 28 Rue du Dr Roux, 75015 Paris, France Grazyna Faure-Kuzminska grazyna.faure-kuzminska@pasteur.fr

About

Prof. Gergely LUKACS

Department of Physiology – McGill University (Montreal, Canada)

Molecular players and mechanisms of plasma membrane proteostasis in health and diseases ; cystic fibrosis and beyond.

abstract
Preserving the function of the plasma membrane proteome is pivotal for cellular and organism physiology to coordinate cell-cell communications, development, differentiation, signaling, metabolism and transport. Using the cystic fibrosis transmembrane conductance regulator (CFTR) variants and other model proteins, we queried the molecular and cellular basis of two fundamental and complementary aspects of the quality control of plasma membrane proteins.  Based on the results, we propose a model that  incorporates two functionally opposite, but complementary pathways as fate determinants of metastable and non-native plasma membrane proteins; the ubiquitination-dependent lysosomal degradation pathway and the molecular chaperone-mediated refolding route. Highlights of the functional duality of molecular chaperones systems in these process will be discussed, including evidence suggesting the capacity of chaperones to partially suppress mutations imposed conformational perturbations of CFTR at the cell surface and at the single molecule level in vitro.

Location

Building: Centre François Jacob
Address: 28 Rue du Dr Roux, 75015 Paris, France