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© Marie Prévost, Institut Pasteur
Image of a portion of a Xenopus oocyte expressing a channel receptor.
Publication : Neuroreport

Regional differential effects of chronic nicotine on brain alpha 4-containing and alpha 6-containing receptors

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Neuroreport - 08 Oct 2008

Even N, Cardona A, Soudant M, Corringer PJ, Changeux JP, Cloëz-Tayarani I

Link to Pubmed [PMID] – 18797314

Neuroreport 2008 Oct;19(15):1545-50

Chronic nicotine upregulates central nicotinic acetylcholine receptors (nAChRs), a plasticity process thought to contribute to its addictive properties. To analyze this process in vivo, we chronically exposed mice to nicotine using minipump delivering nicotine at concentrations close to those found in tobacco smokers. Binding studies show upregulation of high-affinity nAChRs after 21 days of treatment in cortical areas, caudate putamen, nucleus accumbens, hippocampus, ventral tegmental area, and superior colliculi. No upregulation was observed in thalamus and discrete cortical areas. Using wild type and alpha 6-/- mice, we observed a downregulation of alpha 6*-nAChRs in superior colliculi and no effects in other structures. The complex pattern of upregulation/downregulation observed in this study depends on both nAChR composition and regional distribution.

https://www.ncbi.nlm.nih.gov/pubmed/18797314