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© Marie Prévost, Institut Pasteur
Image of a portion of a Xenopus oocyte expressing a channel receptor.
Publication : Anesthesia and analgesia

Anesthetic sensitivity of the Gloeobacter violaceus proton-gated ion channel

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Anesthesia and analgesia - 21 Nov 2009

Weng Y, Yang L, Corringer PJ, Sonner JM

Link to Pubmed [PMID] – 19933531

Anesth. Analg. 2010 Jan;110(1):59-63

A prokaryotic member of the gamma-aminobutyric acid type A receptor superfamily (GLIC) was recently cloned from the cyanobacterium Gloeobacter violaceus, its function characterized, and its 3-dimensional x-ray diffraction crystal structure determined. We report its modulation by 9 anesthetics using 2-electrode voltage clamping in Xenopus laevis oocytes. Desflurane, halothane, isoflurane, sevoflurane, and propofol inhibited currents through GLIC at and below concentrations used clinically. Hill numbers averaged 0.3, indicating negative cooperativity or multiple sites or mechanisms of action. A 2-site model fit the data for desflurane and halothane better than a 1-site model. Xenon and etomidate modulated GLIC at or above clinical concentrations, with no cooperativity. Ethanol and nitrous oxide did not modulate GLIC at surgical anesthetic concentrations. These investigations lay the groundwork for further structural and functional studies of anesthetic actions on GLIC.

http://www.ncbi.nlm.nih.gov/pubmed/19933531