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© Marie Prévost, Institut Pasteur
Image of a portion of a Xenopus oocyte expressing a channel receptor.
Publication : Neuron

Mutational analysis of the charge selectivity filter of the alpha7 nicotinic acetylcholine receptor

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Neuron - 01 Apr 1999

Corringer PJ, Bertrand S, Galzi JL, Devillers-Thiéry A, Changeux JP, Bertrand D

Link to Pubmed [PMID] – 10230802

Neuron 1999 Apr;22(4):831-43

In the alpha7 nicotinic acetylcholine receptors, we analyze the contribution of mutations E237A and V251T, together with the proline insertion P236′, in the conversion of the charge selectivity from cationic to anionic. We show that the triple mutant exhibits spontaneous openings displaying anionic selectivity. Furthermore, at position 251, hydrophilic or even negatively charged residues are compatible with an anionic channel. In contrast, the additional proline yields an anionic channel only when inserted between positions 234 and 237; insertion before 234 yields a cationic channel and after 238 alters the receptor surface expression. The coiled 234-238 loop thus directly contributes to the charge selectivity filter of the alpha7 channel.

http://www.ncbi.nlm.nih.gov/pubmed/10230802