Ligne de temps

Pierre-Jean Corringer
Responsable de Structure
12 févr. 2024
publication

The Nicotinic Acetylcholine Receptor and its Pentameric Homologs: Toward an Allosteric Mechanism of Signal Transduction at the Atomic Level.

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08 févr. 2024
event

Neuroscience Departmental Seminar: “Slow AMPA receptors.”

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01 févr. 2024
publication

Short-chain mono-carboxylates as negative modulators of allosteric transitions in Gloeobacter violaceus ligand-gated ion channel, and impact of a pre-β5 strand (Loop Ω) double mutation on crotonate, not butyrate effect.

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25 sept. 2023
publication

An original potentiating mechanism revealed by the cryo-EM structures of the human α7 nicotinic receptor in complex with nanobodies.

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25 mai 2023
publication

Generation of nanobodies acting as silent and positive allosteric modulators of the α7 nicotinic acetylcholine receptor.

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07 avr. 2023
publication

Fumarate as positive modulator of allosteric transitions in the pentameric ligand-gated ion channel GLIC: Requirement of an intact vestibular pocket.

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13 févr. 2023
publication

Illumination of a progressive allosteric mechanism mediating the glycine receptor activation.

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27 janv. 2023
event

Department of Neuroscience seminar Vladan Lučić (Max Planck Institute of Biochemistry, Germany) – Architecture of synaptic protein assemblies by cryo-electron tomography

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22 déc. 2022
publication

Design of crotoxin-based peptides with potentiator activity targeting the ΔF508NBD1 Cystic Fibrosis Transmembrane Conductance Regulator.

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18 nov. 2022
publication

Conformational state-dependent regulation of GABAA receptor diffusion and subsynaptic domains.

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14 oct. 2022
publication

Lateral fenestrations in the extracellular domain of the glycine receptor contribute to the main chloride permeation pathway.

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30 sept. 2021
publication

Mutational analysis to explore long-range allosteric couplings involved in a pentameric channel receptor pre-activation and activation.

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01 févr. 2021
publication

Alterations in nicotinic receptor alpha5 subunit gene differentially impact early and later stages of cocaine addiction: a translational study in transgenic rats and patients.

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23 oct. 2020
publication

The desensitization pathway of GABAA receptors, one subunit at a time.

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14 nov. 2019
event

DPT NEUROSCIENCE – Thesis defence : Mariano GENERA – Structural and functional study of the human phosphatase PTPN3 and its interaction with oncogenic viruses.

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08 oct. 2019
project

HBP-CDP6: Modelling for Drug Discovery

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08 oct. 2019
project

ANR-Pentacontrol

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08 oct. 2019
project

ERC advanced DYNACOTINE

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02 sept. 2019
event

PhD defense – Solène Lefebvre – “Applications de la fluorescence pour la caractérisation structurale et dynamique d’intermédiaires conformationnels des récepteurs-canaux pentamériques” – Department of Neuroscience

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29 mars 2019
publication

Large Intracellular Domain-Dependent Effects of Positive Allosteric Modulators on Glycine Receptors

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24 janv. 2019
event

Neuroscience Seminar Series : Structure-guided design of synthetic connectors for synaptic repair.

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12 déc. 2018
publication

Electrostatics, proton sensor, and networks governing the gating transition in GLIC, a proton-gated pentameric ion channel

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31 oct. 2018
publication

Conformational transitions of the serotonin 5-HT receptor

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04 sept. 2018
publication

Structural titration of receptor ion channel GLIC gating by HS-AFM

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15 mai 2018
publication

The dual-gate model for pentameric ligand-gated ion channels activation and desensitization.

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09 avr. 2018
publication

Crystal structures of a pentameric ion channel gated by alkaline pH show a widely open pore and identify a cavity for modulation

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27 févr. 2018
project

Toxins and nanobodies as subtype-specific ligands and allosteric modulators of nicotinic acetylcholine receptors (PTR Nicobinder)

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27 févr. 2018
project

Discovery of allosteric modulators specifically targeting α5-containing nAChRs. (ANR-Nicofive)

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24 janv. 2018
project

MECANICOC

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27 déc. 2017
publication

Full mutational mapping of titratable residues helps to identify proton-sensors involved in the control of channel gating in the Gloeobacter violaceus pentameric ligand-gated ion channel

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30 nov. 2017
publication

Interaction of Synthetic Human SLURP-1 with the Nicotinic Acetylcholine Receptors

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14 avr. 2017
event

Neuroscience – unité Récepteurs-Canaux Lab Seminar

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15 juil. 2016
publication

Interaction of three-finger proteins from snake venoms and from mammalian brain with the cys-loop receptors and their models

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06 juin 2016
publication

Phosphorylation state-dependent modulation of spinal glycine receptors alleviates inflammatory pain

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27 mai 2016
publication

Rattlesnake Phospholipase A2 Increases CFTR-Chloride Channel Current and Corrects ∆F508CFTR Dysfunction: Impact in Cystic Fibrosis

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04 mai 2016
publication

Emerging Molecular Mechanisms of Signal Transduction in Pentameric Ligand-Gated Ion Channels

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05 févr. 2016
publication

Neurotoxic phospholipase A2 from rattlesnake as a new ligand and new regulator of prokaryotic receptor GLIC (proton-gated ion channel from G. violaceus)

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14 mai 2015
publication

Ethanol Modulation is Quantitatively Determined by the Transmembrane Domain of Human α1 Glycine Receptors

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03 mars 2015
publication

Allosteric and hyperekplexic mutant phenotypes investigated on an α1 glycine receptor transmembrane structure.

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21 sept. 2014
team

Récepteurs-canaux

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23 déc. 2013
publication

Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation

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01 oct. 2013
publication

Intermediate closed state for glycine receptor function revealed by cysteine cross-linking

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04 juin 2013
publication

Identification of cinnamic acid derivatives as novel antagonists of the prokaryotic proton-gated ion channel GLIC

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05 mars 2013
publication

Structural sensitivity of a prokaryotic pentameric ligand-gated ion channel to its membrane environment

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12 févr. 2013
publication

Structural basis for ion permeation mechanism in pentameric ligand-gated ion channels

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03 oct. 2012
publication

Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines

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06 juin 2012
publication

Structure and pharmacology of pentameric receptor channels: from bacteria to brain

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13 mai 2012
publication

A locally closed conformation of a bacterial pentameric proton-gated ion channel

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23 déc. 2011
publication

[X-ray structures of general anesthetics bound to their molecular targets]

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20 oct. 2011
publication

Unravelling the conformational plasticity of the extracellular domain of a prokaryotic nAChR homologue in solution by NMR

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05 juil. 2011
publication

Functional prokaryotic-eukaryotic chimera from the pentameric ligand-gated ion channel family

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05 juil. 2011
publication

Structural basis for alcohol modulation of a pentameric ligand-gated ion channel

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29 juin 2011
publication

Discrimination of agonists versus antagonists of nicotinic ligands based on docking onto AChBP structures

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20 janv. 2011
publication

X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel

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14 août 2010
publication

3D structure and allosteric modulation of the transmembrane domain of pentameric ligand-gated ion channels

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22 mars 2010
publication

One-microsecond molecular dynamics simulation of channel gating in a nicotinic receptor homologue

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07 déc. 2009
publication

Atomic structure and dynamics of pentameric ligand-gated ion channels: new insight from bacterial homologues

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21 nov. 2009
publication

Anesthetic sensitivity of the Gloeobacter violaceus proton-gated ion channel

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13 nov. 2009
publication

Crystal structure of the extracellular domain of a bacterial ligand-gated ion channel

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01 sept. 2009
publication

Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system

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05 nov. 2008
publication

X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation

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08 oct. 2008
publication

Regional differential effects of chronic nicotine on brain alpha 4-containing and alpha 6-containing receptors

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10 déc. 2006
publication

A prokaryotic proton-gated ion channel from the nicotinic acetylcholine receptor family

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31 oct. 2006
publication

Implications of the quaternary twist allosteric model for the physiology and pathology of nicotinic acetylcholine receptors

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03 févr. 2006
publication

Nicotine enhances intracellular nicotinic receptor maturation: a novel mechanism of neural plasticity?

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19 mai 2005
publication

Nicotine upregulates its own receptors through enhanced intracellular maturation

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01 avr. 2005
publication

Normal mode analysis suggests a quaternary twist model for the nicotinic receptor gating mechanism

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05 févr. 2004
publication

An extracellular protein microdomain controls up-regulation of neuronal nicotinic acetylcholine receptors by nicotine

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01 févr. 2004
publication

Distinct subcellular targeting of fluorescent nicotinic alpha 3 beta 4 and serotoninergic 5-HT3A receptors in hippocampal neurons

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01 mai 2003
publication

An H-bond between two residues from different loops of the acetylcholine binding site contributes to the activation mechanism of nicotinic receptors

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01 déc. 2002
publication

The diversity of subunit composition in nAChRs: evolutionary origins, physiologic and pharmacologic consequences

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25 sept. 2002
publication

Allosteric transitions of Torpedo acetylcholine receptor in lipids, detergent and amphipols: molecular interactions vs. physical constraints

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26 févr. 2002
publication

Experimentally based model of a complex between a snake toxin and the alpha 7 nicotinic receptor

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13 mars 2001
publication

A method for soluble overexpression of the alpha7 nicotinic acetylcholine receptor extracellular domain

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20 févr. 2001
publication

Desensitization of neuronal nicotinic acetylcholine receptors conferred by N-terminal segments of the beta 2 subunit

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22 sept. 2000
publication

Molecular determinants by which a long chain toxin from snake venom interacts with the neuronal alpha 7-nicotinic acetylcholine receptor

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13 juin 2000
publication

Structural differences in the two agonist binding sites of the Torpedo nicotinic acetylcholine receptor revealed by time-resolved fluorescence spectroscopy

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30 mars 2000
publication

Molecular characterization of the specificity of interactions of various neurotoxins on two distinct nicotinic acetylcholine receptors

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01 janv. 2000
publication

Nicotinic receptors at the amino acid level

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01 mai 1999
publication

Improved secondary structure predictions for a nicotinic receptor subunit: incorporation of solvent accessibility and experimental data into a two-dimensional representation

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01 avr. 1999
publication

Mutational analysis of the charge selectivity filter of the alpha7 nicotinic acetylcholine receptor

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01 mai 1998
publication

Brain nicotinic receptors: structure and regulation, role in learning and reinforcement

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01 avr. 1998
publication

Functional determinants by which snake and cone snail toxins block the alpha 7 neuronal nicotinic acetylcholine receptors

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01 févr. 1998
publication

Ivermectin: a positive allosteric effector of the alpha7 neuronal nicotinic acetylcholine receptor

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15 janv. 1998
publication

Critical elements determining diversity in agonist binding and desensitization of neuronal nicotinic acetylcholine receptors

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10 nov. 1997
publication

Paradoxical allosteric effects of competitive inhibitors on neuronal alpha7 nicotinic receptor mutants

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01 nov. 1996
publication

Identification of calcium binding sites that regulate potentiation of a neuronal nicotinic acetylcholine receptor

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01 janv. 1996
publication

Nicotinic receptors and brain plasticity

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19 mai 1995
publication

Identification of a new component of the agonist binding site of the nicotinic alpha 7 homooligomeric receptor

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01 févr. 1995
publication

CCKA, but not CCKB, agonists suppress the hyperlocomotion induced by endogenous enkephalins, protected from enzymatic degradation by systemic RB 101

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01 janv. 1993
publication

CCK-B agonist or antagonist activities of structurally hindered and peptidase-resistant Boc-CCK4 derivatives

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01 nov. 1992
publication

[Study of induced effects by selective CCKB agonists cholecystokinin in the nociception and behavior in rodents]

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01 juin 1992
publication

[3H]pBC 264, a suitable probe for studying cholecystokinin-B receptors: binding characteristics in rodent brains and comparison with [3H]SNF 8702

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13 sept. 1989
publication

[3H]pBC 264, first highly potent and very selective radioligand for CCK-B receptors

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