- We use biophysical experimental techniques such as crystallography and cryo-EM to visualize at the atomic level the structure of molecules essential to life, such as DNA polymerases involved in DNA Repair and Cancer and ion channels involved in electric nerve signalling (cell-cell communications).
- We complement them with molecular and normal modes dynamics, so as to go beyond the essentially static pictures given by these methods.
- We also try to better understand the electrostatics of macromolecules and their interaction with the solvent and ligands, in order to be able to predict their binding properties.
- Our main goal is to design structure-inspired drugs (pharmacology) and re-design active site(s) to make them accept other substrates (synthetic biology).
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2018Enzymatic synthesis of random sequences of RNA and RNA analogues by DNA polymerase theta mutants for the generation of aptamer libraries, Nucleic Acids Res. 2018 Jul;46(12):6271-6284.
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2018Enzymatic synthesis of random sequences of RNA and RNA analogues by DNA polymerase t heta mutants for the generation of aptamer libraries, in press.
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2018Terminal deoxynucleotidyltransferase: the story of an untemplated DNA polymerase capable of DNA bridging and templated synthesis across strands, Curr Opin Struct Biol. 2018 Apr 12;53:22-31..
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2018Structural basis for a bimodal allosteric mechanism of general anesthetic modulation in pentameric ligand-gated ion channels, Cell Rep. 2018 Apr 24;23(4):993-1004..
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2018Crystal structures of a pentameric ion channel gated by alkaline pH show a widely open pore and identify a cavity for modulation, Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):E3959-E3968..
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2017Full mutational mapping of titratable residues helps to identify proton-sensors involved in the control of channel gating in the Gloeobacter violaceus pentameric ligand-gated ion channel., PLoS Biol. 2017 15(12):e2004470..
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2017Ab initio sampling of transition paths by Conditioned Langevin Dynamics, J Chem Phys. 2017 Oct 21;147(15):152703..
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2017The Renormalization Group and Its Applications to Generating Coarse-Grained Models of Large Biological Molecular Systems., J Chem Theory Comput. 2017 Mar 14;13(3):1424-1438..
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2017Barbiturates Bind in the GLIC Ion Channel Pore and Cause Inhibition by Stabilizing a Closed State, J Biol Chem. 2017 Feb 3;292(5):1550-1558..
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2016Comparative Normal Mode Analysis of the Dynamics of DENV and ZIKV Capsids, Front Mol Biosci 2016;3:85.
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Contact
Marie de Tarragon
Phone: Ext. 86 96
Email: marie.de-tarragon@pasteur.fr
Address
Unite de Dynamique Structurales des Macromolecules Biologiques
25-28 Rue du Docteur Roux
75015, Paris
France