- We use biophysical experimental techniques such as crystallography and cryo-EM to visualize at the atomic level the structure of molecules essential to life, such as DNA polymerases involved in DNA Repair and Cancer and ion channels involved in electric nerve signalling (cell-cell communications).
- We complement them with molecular and normal modes dynamics, so as to go beyond the essentially static pictures given by these methods.
- We also try to better understand the electrostatics of macromolecules and their interaction with the solvent and ligands, in order to be able to predict their binding properties.
- Our main goal is to design structure-inspired drugs (pharmacology) and re-design active site(s) to make them accept other substrates (synthetic biology).
- More details can be found at http://lorentz.dynstr.pasteur.fr
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2019Structural evidence for an in base selection mechanism involving Loop1 in polymerase μ at an NHEJ double-strand break junction, J. Biol. Chem. 2019 Jul;294(27):10579-10595.
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2019Rapid enzymatic synthesis of long RNA polymers: A simple protocol to generate RNA libraries with random sequences, Methods 2019 May;161:83-90.
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2019Structure of the DP1-DP2 PolD complex bound with DNA and its implications for the evolutionary history of DNA and RNA polymerases, PLoS Biol. 2019 Jan;17(1):e3000122.
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2019An updated structural classification of replicative DNA polymerases, Biochem. Soc. Trans. 2019 02;47(1):239-249.
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2018Numerical Encodings of Amino Acids in Multivariate Gaussian Modeling of Protein Multiple Sequence Alignments, Molecules 2018 Dec;24(1).
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2018Electrostatics, proton sensor, and networks governing the gating transition in GLIC, a proton-gated pentameric ion channel, Proc. Natl. Acad. Sci. U.S.A. 2018 12;115(52):E12172-E12181.
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2018Coarse-grained dynamics of supramolecules: Conformational changes in outer shells of Dengue viruses, Prog. Biophys. Mol. Biol. 2019 May;143:20-37.
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2018Combined approaches from physics, statistics, and computer science for protein structure prediction: (unity is strength)?, F1000Res 2018;7.
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2018Enzymatic synthesis of random sequences of RNA and RNA analogues by DNA polymerase theta mutants for the generation of aptamer libraries, Nucleic Acids Res. 2018 07;46(12):6271-6284.
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2018Structural Basis for a Bimodal Allosteric Mechanism of General Anesthetic Modulation in Pentameric Ligand-Gated Ion Channels, Cell Rep 2018 04;23(4):993-1004.
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Contact
Marie de Tarragon Phone: Ext. 86 96 Email: marie.de-tarragon@pasteur.fr Address Unite de Dynamique Structurales des Macromolecules Biologiques 25-28 Rue du Docteur Roux 75015, Paris France