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© Structural Dynamics Of Macromolecules
The structure of a bacterial analog of the nicotinic receptor (one color per subunit) inserted into the cell membrane (grey and orange). A representation of the volume accessible to ions is shown in yellow.

About

  • We use biophysical experimental techniques such as crystallography and SAXS to visualize at the atomic level the structure of molecules essential to life, such as DNA polymerases involved in DNA Repair and Cancer and ion channels involved in electric nerve signalling.
  • We complement them with molecular and normal modes dynamics, so as to go beyond the essentially static pictures given by these methods.
  • We also try to better understand the electrostatics of macromolecules and their interaction with the solvent, in order to be able to predict their binding properties.
  • Our main goal is to design structure-inspired drugs (pharmacology) and re-design active site(s) to make them accept other substrates (synthetic biology).
  • delarue.jpg

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