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© Institut Pasteur
Cryptococcus neoformans
Publication : microLife

Structure, composition and biological properties of fungal extracellular vesicles

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in microLife - 24 Jun 2021

Rizzo J, Taheraly A, Janbon G

Link to DOI – 10.1093/femsml/uqab009

microLife, Volume 2, 2021, uqab009

Extracellular vesicles (EVs) are lipidic nanosized particles that deliver a highly complex molecular cargo between cells and organisms and may serve numerous functions in intercellular communication, thereby influencing the evolution of microbial communities. Their roles in infectious diseases have been studied for a long time, comprising viral, bacterial, parasitic and to a less extent, fungal infections. Over the last few years, fungal EVs have become an increasingly active research field. Nevertheless, the understanding of EV functions during fungal infections poses challenging points, comprising the genetics regulating EV release, the EV structural and compositional complexity, the heterogeneity of the EV populations and their impact on host-pathogen interactions. This review explores the state-of-the-art investigations on fungal EVs and how this fast-evolving field can impact the development of new tools to fight fungal infections.

https://doi.org/10.1093/femsml/uqab009