Guilherme Dias de Melo is veterinarian. He obtained his degree in Veterinary Medicine (december 2010), his MD in Veterinary Sciences (june 2012) and his PhD in Veterinary Sciences (june 2015) at the Sao Paulo State University – Araçatuba, Brazil. He is currently a Post-doc researcher at the Trypanosomatids Infectious Processes Lab.
General Objectives of the Unit Lyssavirus Dynamics and Host adaptation
Detailed objectives of the research program 1) How lyssavirus infection moves in both space and in time and the role played by ecological factors in the dispersal of lyssaviruses in bats and dogs. The […]
Host cell-lyssavirus interplay and virulence
The research activities of our group focus on the understanding of the complex relationship between immunity and neural functions during rabies virus (RABV) infection, which should ultimately help in the comprehension of viral encephalitis […]
Towards the development of diagnostic tests for Chagas disease and post-treatment monitoring by the use of specific markers of the parasite Trypanosoma cruzi and prognostic biomarkers of chronic phase of infection. Current methods available […]
Concerted effort to address rational drug design against Chagas disease Through a multidisciplinary approach that combine medicinal chemistry, structural bioinformatics, molecular docking and immunobiology of the infectious process, we identified two new inhibitors of […]
|2012-2015||PhD||Veterinary Science||Sao Paulo State University, Araçatuba-SP, Brazil|
|2011-2012||MSc||Veterinary Science||Sao Paulo State University, Araçatuba-SP, Brazil|
|2006-2010||DVM||Veterinary Medicine||Sao Paulo State University, Araçatuba-SP, Brazil|
|2014-2015||Immunology/Parasitology||Trypanosomatids Infectious Processes, Institut Pasteur, Paris, France|
|2011-2011||Veterinary Pathology||Institut of Veterinary Pathology, Justus-Liebig University, Giessen, Germany|
- 2015-to date – Trypanosomatids Infectious Processes, Institut Pasteur, Paris, France
Awards and Grants
- 2006-2015 – Fellow of Sao Paulo Research Foundation (FAPESP, Fundação de Amparo à Pesquisa do Estado de São Paulo) (DVM #2006/56724-3; MSc #2010/12473-2; PhD #2012/10415-0)
- 2013 – ICI-AAI Travel Grant for Immunologists from Developing Countries – 15th International Congress of Immunology (ICI) – Milan, Italy
- 2013 – Best poster in Cellular and Molecular Biology – Fifth World Congress on Leishmaniasis (World Leish 5) – Porto de Galinhas, Brazil
- 2011 – Travel Grant – 11th European School of Neuroimmunology (ESNI), Glasgow, Scotland
2020A combination of two human monoclonal antibodies cures symptomatic rabies., EMBO Mol Med 2020 Sep; (): e12628.
2020Structure of the prefusion-locking broadly neutralizing antibody RVC20 bound to the rabies virus glycoprotein., Nat Commun 2020 01; 11(1): 596.
2015Feasibility and safety of intrathecal transplantation of autologous bone marrow mesenchymal stem cells in horses, BMC Vet. Res. 2015;11:63.
2014Compartmentalized gene expression of toll-like receptors 2, 4 and 9 in the brain and peripheral lymphoid organs during canine visceral leishmaniasis, Parasite Immunol. 2014 Dec;36(12):726-31.
2014First detection of Leishmania infantum DNA within the brain of naturally infected dogs, Vet. Parasitol. 2014 Aug;204(3-4):376-80.
2013T and B lymphocytes in the brains of dogs with concomitant seropositivity to three pathogenic protozoans: Leishmania chagasi, Toxoplasma gondii and Neospora caninum, BMC Res Notes 2013;6:226.
2013Ki-67 labeling in canine perianal glands neoplasms: a novel approach for immunohistological diagnostic and prognostic, BMC Vet. Res. 2013;9:83.
2013Zymographic patterns of MMP-2 and MMP-9 in the CSF and cerebellum of dogs with subacute distemper leukoencephalitis, Vet. Immunol. Immunopathol. 2013 Jul;154(1-2):68-74.
2013Bovine herpesvirus-5 infection in a rabbit experimental model: immunohistochemical study of the cellular response in the CNS, Microb. Pathog. 2013 Apr;57:10-6.
2012Porencephaly and cortical dysplasia as cause of seizures in a dog, BMC Vet. Res. 2012;8:246.
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