Guilherme Dias de Melo is veterinarian. He obtained his degree in Veterinary Medicine (december 2010), his MD in Veterinary Sciences (june 2012) and his PhD in Veterinary Sciences (june 2015) at the Sao Paulo State University – Araçatuba, Brazil. He is currently a Post-doc researcher at the Lyssavirus Epidemiology and Neuropathology Unit.
General Objectives of the Unit Lyssavirus Dynamics and Host adaptation
Detailed objectives of the research program 1) How lyssavirus infection moves in both space and in time and the role played by ecological factors in the dispersal of lyssaviruses in bats and dogs. The […]
Host cell-lyssavirus interplay and virulence
The research activities of our group focus on the understanding of the complex relationship between immunity and neural functions during rabies virus (RABV) infection, which should ultimately help in the comprehension of viral encephalitis […]
Towards the development of diagnostic tests for Chagas disease and post-treatment monitoring by the use of specific markers of the parasite Trypanosoma cruzi and prognostic biomarkers of chronic phase of infection. Current methods available […]
Concerted effort to address rational drug design against Chagas disease Through a multidisciplinary approach that combine medicinal chemistry, structural bioinformatics, molecular docking and immunobiology of the infectious process, we identified two new inhibitors of […]
|2012-2015||PhD||Veterinary Science||Sao Paulo State University, Araçatuba-SP, Brazil|
|2011-2012||MSc||Veterinary Science||Sao Paulo State University, Araçatuba-SP, Brazil|
|2006-2010||DVM||Veterinary Medicine||Sao Paulo State University, Araçatuba-SP, Brazil|
|2014-2015||Immunology/Parasitology||Trypanosomatids Infectious Processes, Institut Pasteur, Paris, France|
|2011-2011||Veterinary Pathology||Institut of Veterinary Pathology, Justus-Liebig University, Giessen, Germany|
- 2018-ongoing – Lyssavirus Epidemiology and Neuropathology Unit, Institut Pasteur, Paris, France
- 2015-2017 – Trypanosomatids Infectious Processes, Institut Pasteur, Paris, France
Awards and Grants
- 2006-2015 – Fellow of Sao Paulo Research Foundation (FAPESP, Fundação de Amparo à Pesquisa do Estado de São Paulo) (DVM #2006/56724-3; MSc #2010/12473-2; PhD #2012/10415-0)
- 2013 – ICI-AAI Travel Grant for Immunologists from Developing Countries – 15th International Congress of Immunology (ICI) – Milan, Italy
- 2013 – Best poster in Cellular and Molecular Biology – Fifth World Congress on Leishmaniasis (World Leish 5) – Porto de Galinhas, Brazil
- 2011 – Travel Grant – 11th European School of Neuroimmunology (ESNI), Glasgow, Scotland
2022Potent human broadly SARS-CoV-2-neutralizing IgA and IgG antibodies effective against Omicron BA.1 and BA.2, J Exp Med . 2022 Jul 4;219(7):e20220638. doi: 10.1084/jem.20220638. Epub 2022 Jun 15. .
2022Potent human broadly SARS-CoV-2-neutralizing IgA and IgG antibodies effective against Omicron BA.1 and BA.2., J Exp Med 2022 Jul; 219(7): .
2021A live measles-vectored COVID-19 vaccine induces strong immunity and protection from SARS-CoV-2 challenge in mice and hamsters., Nat Commun 2021 11; 12(1): 6277.
2021Attenuation of clinical and immunological outcomes during SARS-CoV-2 infection by ivermectin., EMBO Mol Med 2021 08; 13(8): e14122.
2021COVID-19-related anosmia is associated with viral persistence and inflammation in human olfactory epithelium and brain infection in hamsters., Sci Transl Med 2021 06; 13(596): .
2020A combination of two human monoclonal antibodies cures symptomatic rabies., EMBO Mol Med 2020 Sep; (): e12628.
2020Structure of the prefusion-locking broadly neutralizing antibody RVC20 bound to the rabies virus glycoprotein., Nat Commun 2020 01; 11(1): 596.
2015Feasibility and safety of intrathecal transplantation of autologous bone marrow mesenchymal stem cells in horses, BMC Vet. Res. 2015;11:63.
2014Compartmentalized gene expression of toll-like receptors 2, 4 and 9 in the brain and peripheral lymphoid organs during canine visceral leishmaniasis, Parasite Immunol. 2014 Dec;36(12):726-31.
2014First detection of Leishmania infantum DNA within the brain of naturally infected dogs, Vet. Parasitol. 2014 Aug;204(3-4):376-80.
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