Search anything and hit enter
  • Teams
  • Members
  • Projects
  • Events
  • Calls
  • Jobs
  • publications
  • Software
  • Tools
  • Network
  • Equipment

A little guide for advanced search:

  • Tip 1. You can use quotes "" to search for an exact expression.
    Example: "cell division"
  • Tip 2. You can use + symbol to restrict results containing all words.
    Example: +cell +stem
  • Tip 3. You can use + and - symbols to force inclusion or exclusion of specific words.
    Example: +cell -stem
e.g. searching for members in projects tagged cancer
Search for
Count
IN
OUT
Content 1
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Clinical Research Nurse
  • Clinician Researcher
  • Department Manager
  • Dual-education Student
  • Full Professor
  • Honorary Professor
  • Lab assistant
  • Master Student
  • Non-permanent Researcher
  • Nursing Staff
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Prize
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Content 2
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Clinical Research Nurse
  • Clinician Researcher
  • Department Manager
  • Dual-education Student
  • Full Professor
  • Honorary Professor
  • Lab assistant
  • Master Student
  • Non-permanent Researcher
  • Nursing Staff
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Prize
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Search
Go back
Scroll to top
Share

About

Our lab aims at studying the molecular basis of antibody B-cell responses to viruses such as HIV-1, Hepatitis viruses and emerging viruses, and the mechanisms by which anti-viral antibodies participate in controlling infections in humans.

Adaptive immune responses naturally occurring upon infection or induced by vaccination generate high affinity antibodies to culprit antigens, and memory B-cell subsets to respond to further antigenic challenges, providing protection against (re-)infections.

The dissection of anti-pathogen B-cell responses using efficient technologies to generate and characterize at a molecular and functional level, antigen-specific human monoclonal antibodies (mAbs) has allowed breakthrough discoveries on the humoral responses against pathogens such as HIV-1, Influenza, Ebola, and Zika viruses, which culminated more recently with the SARS-CoV-2 research.

These recombinant mAbs represent unique “fingerprints” for each B-cell clone and when characterized in details at  molecular and functional levels, provide crucial information about the humoral response to the pathogen. Moreover, in addition to the antibody’ therapeutic interest, it has now become evident that studying the biology of neutralizing mAbs is  pivotal in designing candidate immunogens for vaccine development. In this context, our research focuses on understanding the mechanisms governing human antibody B-cell response to pathogens, and to make use of these findings to develop therapeutic strategies.

Using complementary technological approaches, including single-cell capture and cloning of human monoclonals, we are currently investigating the memory B-cell responses to HIV-1 at the peripheral and mucosal level in individuals who developed extremely potent and broad neutralizing HIV-1 antibodies (bNAbs), this in trying to understand how these rare antibodies develop.

Our scientific investigations also use this research approach and methodological strategy to study B-cell memory and biology in physiological conditions, and B-cell antibody responses to other viral pathogens such as Hepatitis viruses as well as those responsible for emerging infections as for instance, Chikungunya and SARS-CoV-2 viruses.


The HI-LAB

April 2019

Over the years….

Former Members

2000
2000
Name
Position
|
|
Salomé Bourgeau
Undergraduate Student
|
|
Cloé Comarmond
MD / Undergraduate Student
|
|
Cindy Marques
MD / Undergraduate Student
|
|
Nizar Joher
MD / Undergraduate Student
|
|
Thierry Hieu
Bioinformatician
|
|
Marine Malbec
Post-doc
|
|
Julie Prigent
Post-doc
|
|
Ayrin Kök-Harunova
Post-doc
|
|
Oxana Vratskikh
Post-doc
|
|
Verena Hehle
Post-doc
|
|
Luis Molinos-Albert
Post-doc
|
|
Maxime Beretta
Post-doc
Show all

Projects

Transversal Project

Fundings

Partners

Publications

Download

Contact

Phone: +33(0)1 40 61 36 12Sans titre Email: hugo.mouquet@pasteur.fr Address 25-28 Rue du Docteur Roux 75015, Paris France