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© Olivier Schwartz, Institut Pasteur
Scientific Fields
Diseases
Organisms
Applications
Technique

About

Dr. Mouquet earned a BS in Biochemistry, a MS in Biochemistry & Molecular Biology and a PhD in Immunology from the University of Rouen (Normandy, France). He performed his post-doctoral trainee in the laboratory of Michel C. Nussenzweig at the Rockefeller University (2007-2013), where he studied B-cell antibody response to HIV-1, isolated and characterized HIV-1 bNAbs. In 2013, Hugo started his group as a young investigator in the immunology department of the Institut Pasteur, supported by an ERC starting grant award. He currently heads the laboratory of Humoral Immunology at the Institut Pasteur. His lab investigates the humoral responses to pathogens in humans with a focus on HIV-1, Hepatitis viruses and emerging infections, and a dual interest in basic and translational research.

Projects

Project
Ongoing
3 Members

Antibody memory B-cell response to Chikungunya virus

Hugo Mouquet (PI)

Chikungunya is a mosquito-transmitted disease of sub-tropical areas caused by an alphavirus, the Chikungunya virus (CHIKV). CHIKV infection has re-emerged after several decades causing large outbreaks, making it an important public health concern. The […]
Project
Ongoing
3 Members

Humoral immunoprofiling in HIV-1 post-treatment controllers

Hugo Mouquet (PI)

Rare infected individuals who initiated antiretroviral therapy (ART) very early during primary infection can enter in remission after its interruption, a phenomenon known as post-treatment control. Interestingly, early treatment has been associated with the […]
Project
Ongoing
4 Members

Humoral immune response & immunotherapy in HBV infection

Hugo Mouquet (PI)

Human infections caused by hepatitis B virus (HBV) are major healthcare issues. Despite available effective vaccines, more than 250 million individuals worldwide are chronically infected by HBV, which accounts for approximately 1 million deaths […]
Project
Ongoing
5 Members

Humoral immunity & human monoclonal antibodies against SARS-CoV-2

Hugo Mouquet (PI)

The objective of this research project is to understand the molecular and functional basis of the memory B-cell antibody response to the SARS-CoV-2 Spike protein. One of the key goals of this research program […]
Project
Ongoing
7 Members

Archive of the Group for AIDS Research

Lisa Chakrabarti (PI)

This page contains the list of past meetings held by the Group for AIDS Research (Groupe de Réflexion SIDA) of the Pasteur Institute since 2014. The list of previous meetings held since 2002 can […]
Project
Ongoing
13 Members

Group for AIDS Research

Nicoletta Casartelli (PI)

The Group for AIDS Research (Groupe de Réflexion SIDA, GRS) organizes  bimonthly meetings and seminars around an HIV / AIDS research topic. Since 2021, the meetings may also include topics related to emerging viruses. […]
Project
Ongoing
4 Members

Intestinal and IgA B-cell responses to HIV-1

Hugo Mouquet (PI)

Mucosal transmission of HIV-1 can induce a local production of IgG and IgA antibodies predominantly targeting the gp41 subunit of the viral envelope glycoprotein gp160. However, whether they limit viral dissemination upon HIV-1 exposure […]
Project
Completed
5 Members

Clonal B cells in HCV-induced cryoglobulinemia vasculitis

Hugo Mouquet (PI)

Hepatitis C virus (HCV) infection can trigger the development of autoimmune disorders among which, cryobulininemic vasculatitis is the most prevalent. HCV-associated cryobulininemic vasculatitis is mediated by mono-/oligo-clonal IgM cryoglobulins with rheumatoid factor activity, thought […]
Project
Ongoing
4 Members

Antiviral properties of broadly neutralizing HIV-1 antibodies

Hugo Mouquet (PI)

Broadly neutralizing HIV-1 antibodies (bNAbs) can develop in rare infected individuals several years after co-evolution with diversifying viruses. In animal models, passive immunotherapy with potent HIV-1 bNAbs has been shown to protect from infection […]
Project
Completed
9 Members

ERC-2013-StG HumAntiViruses

Hugo Mouquet (PI)

Human Antibody Responses to Viruses Adaptive immune responses naturally occurring upon infection or induced by vaccination generate high affinity antibodies, and memory B-cell subsets to respond to further antigenic challenges, providing protection against (re-)infections. […]

Publications

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