Hugo Mouquet received his phD in immunology from the University of Rouen (France), following his work on the characterization of T-cell and B-cell responses in an autoimmune disease of the skin called Pemphigus. He then moved to the Rockefeller University to perform his postdoctoral trainee in the lab headed by Michel C. Nussenzweig, where he studied B-cell antibody response to HIV-1 in humans. Since 2013, Hugo Mouquet is a group leader in the immunology department of the Institut Pasteur. His lab investigates the humoral response to viruses in humans.
Think tank: B cells
The B-cell Interest Group (BIG) is a think-tank of immunologists focusing their research activities on diverse aspects of B lymphocytes and their effector molecules, antibodies. It gathers experts from the Institut Pasteur, the INEM […]
Group for AIDS Research
The Group for AIDS Research (Groupe de Réflexion SIDA, GRS) organizes bimonthly meetings and seminars around an HIV / AIDS research topic. Meetings and seminars are open to all. Meetings are usually held on […]
Influence of ART Timing on Mucosal B-cell Responses in HIV-1 Infected Individuals
This project in collaboration with Dr Sophie Huë (Service d’Immunologie Biologique, Hôpital Henri Mondor), and funded by Sidaction aims at understanding whether the timing of the antiretroviral therapy (ART) for AIDS treatment can positively influence B-cell / antibody responses […]
Clonal B cells in Cryoglobulinemia Vasculitis with Hepatitits C Infection
This project funded by the ANRS is a collaborative study with Dr David Saadoun (Hôpital La pitié Salpétrière, Inserm U959), which focuses on the characterization of the clonal B-cell expansions typically found in cryoglobulinemia vasculitis associated […]
Antiviral Properties of Broadly Neutralizing HIV-1 Antibodies
Broadly neutralizing HIV-1 antibodies (bNAbs) can develop in rare infected individuals several years after co-evolution with diversifying viruses. In animal models, passive immunotherapy with potent HIV-1 bNAbs has been shown to protect from infection […]
Human Antibody Responses to Viruses The goal of this project supported by the European Research Council (Grant: ERC-2013-StG HumAntiViruses) is to study memory B-cell antibody responses to human pathogens, especially viruses, by generating and characterizing […]
Methodological Approaches for Rapid Antibody Discovery
Capture of Single Antigen-Specific B cells to Produce Human Monoclonal Antibodies to Pathogens To achieve our research goals, we are making use of a very efficient method to clone and express immunoglobulins from human […]
2018A human immune system mouse model with robust lymph node development, Nat. Methods 2018 Aug;15(8):623-630.
2018Conformational Plasticity in Broadly Neutralizing HIV-1 Antibodies Triggers Polyreactivity, Cell Rep 2018 May;23(9):2568-2581.
2018Early Antiretroviral Therapy Preserves Functional Follicular Helper T and HIV-Specific B Cells in the Gut Mucosa of HIV-1-Infected Individuals, J. Immunol. 2018 Apr;.
2017Humanized mouse models to study pathophysiology and treatment of HIV infection, Curr Opin HIV AIDS 2017 Nov;13(2):143-151.
2017Genetically intact but functionally impaired HIV-1 Env glycoproteins in the T-cell reservoir, J. Virol. 2017 Nov;.
2017What Are the Primary Limitations in B-Cell Affinity Maturation, and How Much Affinity Maturation Can We Drive with Vaccination? Lessons from the Antibody Response to HIV-1, Cold Spring Harb Perspect Biol 2017 Jun;.
2017Impact of Antigen Density on the Binding Mechanism of IgG Antibodies, Sci Rep 2017 Jun;7(1):3767.
2017HIV-Specific B Cell Frequency Correlates with Neutralization Breadth in Patients Naturally Controlling HIV-Infection, EBioMedicine 2017 May;.
2017Hunting Down the HIV-1 Reservoir: A Starring Role for Antibodies?, Immunity 2017 Apr;46(4):527-529.
2017Respiratory Syncytial Virus Infects Regulatory B Cells in Human Neonates via Chemokine Receptor CX3CR1 and Promotes Lung Disease Severity, Immunity 2017 Feb;46(2):301-314.
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