Dr. Mouquet earned a BS in Biochemistry, a MS in Biochemistry & Molecular Biology and a PhD in Immunology from the University of Rouen (Normandy, France). He performed his post-doctoral trainee in the laboratory of Michel C. Nussenzweig at the Rockefeller University (2007-2013), where he studied B-cell antibody response to HIV-1, isolated and characterized HIV-1 bNAbs. In 2013, Hugo started his group as a young investigator in the immunology department of the Institut Pasteur, supported by an ERC starting grant award. He currently heads the laboratory of Humoral Immunology at the Institut Pasteur. His lab investigates the humoral responses to pathogens in humans with a focus on HIV-1, Hepatitis viruses and emerging infections, and a dual interest in basic and translational research.
Archive of the Group for AIDS Research
This page contains the list of past meetings held by the Group for AIDS Research (Groupe de Réflexion SIDA) of the Pasteur Institute since 2014. The list of previous meetings held since 2002 can […]
Group for AIDS Research
The Group for AIDS Research (Groupe de Réflexion SIDA, GRS) organizes bimonthly meetings and seminars around an HIV / AIDS research topic. Meetings and seminars are open to all. Meetings are usually held on […]
Influence of ART Timing on Mucosal B-cell Responses in HIV-1 Infected Individuals
This project in collaboration with Dr Sophie Huë (Service d’Immunologie Biologique, Hôpital Henri Mondor), and funded by Sidaction aims at understanding whether the timing of the antiretroviral therapy (ART) for AIDS treatment can positively influence B-cell / antibody responses […]
Clonal B cells in Cryoglobulinemia Vasculitis with Hepatitits C Infection
Hepatitis C virus (HCV) infection can contribute to the development of autoimmune disorders, but the mechanisms responsible for HCV-associated autoimmunity are not well understood. In collaboration with Pr David Saadoun (Hôpital La pitié […]
Antiviral Properties of Broadly Neutralizing HIV-1 Antibodies
Broadly neutralizing HIV-1 antibodies (bNAbs) can develop in rare infected individuals several years after co-evolution with diversifying viruses. In animal models, passive immunotherapy with potent HIV-1 bNAbs has been shown to protect from infection […]
Human Antibody Responses to Viruses The goal of this project supported by the European Research Council (Grant: ERC-2013-StG HumAntiViruses) is to study memory B-cell antibody responses to human pathogens, especially viruses, by generating and characterizing […]
Methodological Approaches for Rapid Antibody Discovery
Capture of Single Antigen-Specific B cells to Produce Human Monoclonal Antibodies to Pathogens To achieve our research goals, we are making use of a very efficient method to clone and express immunoglobulins from human […]
2019TLR9 Signaling in HCV-Associated Atypical Memory B Cells Triggers Th1 and Rheumatoid Factor Autoantibody Responses, J. Hepatol. 2019 Jul;.
2019HIV-1 Envelope Recognition by Polyreactive and Cross-Reactive Intestinal B Cells, Cell Rep 2019 Apr;27(2):572-585.e7.
2018A human immune system mouse model with robust lymph node development, Nat. Methods 2018 Aug;15(8):623-630.
2018Conformational Plasticity in Broadly Neutralizing HIV-1 Antibodies Triggers Polyreactivity, Cell Rep 2018 May;23(9):2568-2581.
2018Early Antiretroviral Therapy Preserves Functional Follicular Helper T and HIV-Specific B Cells in the Gut Mucosa of HIV-1-Infected Individuals, J. Immunol. 2018 Apr;.
2017Humanized mouse models to study pathophysiology and treatment of HIV infection, Curr Opin HIV AIDS 2017 Nov;13(2):143-151.
2017Genetically intact but functionally impaired HIV-1 Env glycoproteins in the T-cell reservoir, J. Virol. 2017 Nov;.
2017What Are the Primary Limitations in B-Cell Affinity Maturation, and How Much Affinity Maturation Can We Drive with Vaccination? Lessons from the Antibody Response to HIV-1, Cold Spring Harb Perspect Biol 2017 Jun;.
2017Impact of Antigen Density on the Binding Mechanism of IgG Antibodies, Sci Rep 2017 Jun;7(1):3767.
2017HIV-Specific B Cell Frequency Correlates with Neutralization Breadth in Patients Naturally Controlling HIV-Infection, EBioMedicine 2017 May;.
+View full list of publications