Dr. Mouquet earned a BS in Biochemistry, a MS in Biochemistry & Molecular Biology and a PhD in Immunology from the University of Rouen (Normandy, France). He performed his post-doctoral trainee in the laboratory of Michel C. Nussenzweig at the Rockefeller University (2007-2013), where he studied B-cell antibody response to HIV-1, isolated and characterized HIV-1 bNAbs. In 2013, Hugo started his group as a young investigator in the immunology department of the Institut Pasteur, supported by an ERC starting grant award. He currently heads the laboratory of Humoral Immunology at the Institut Pasteur. His lab investigates the humoral responses to pathogens in humans with a focus on HIV-1, Hepatitis viruses and emerging infections, and a dual interest in basic and translational research.
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2025Structural basis for hepatitis E virus neutralization by potent human antibodies., Sci Adv 2025 May; 11(19): eadu8811.
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2025HIV-1 broadly neutralizing antibodies demonstrate a high propensity for binding to heme., J Immunol 2025 Mar; (): .
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2025Humoral immunity in HIV-1 post-treatment controllers., Curr Opin HIV AIDS 2025 Jan; 20(1): 80-85.
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2024Enhanced hepatitis B virus-specific immunity by combining neutralizing antibody therapy and DNA vaccination in a murine model of chronic hepatitis B virus infection., Hepatology 2024 Dec; (): .
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2024Enhanced hepatitis B virus-specific immunity by combined neutralizing antibody therapy and DNA vaccination in a murine model of chronic hepatitis B infection, Hepatology.
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2024Intestinal newborn regulatory B cell antibodies modulate microbiota communities., Cell Host Microbe 2024 Oct; 32(10): 1787-1804.e9.
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2024Sustained HIV remission after allogeneic hematopoietic stem cell transplantation with wild-type CCR5 donor cells., Nat Med 2024 Sep; (): .
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2024Broad sarbecovirus neutralization by combined memory B cell antibodies to ancestral SARS-CoV-2., iScience 2024 Jul; 27(7): 110354.
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2024[IgA antibodies against HIV-1]., Virologie (Montrouge) 2024 May; 0(0): .
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2024Early antiretroviral therapy favors post-treatment SIV control associated with the expansion of enhanced memory CD8+ T-cells., Nat Commun 2024 Jan; 15(1): 178.
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