Assistant Professor, CR IP (PhD 1992 Paris XI, HDR 2009 Paris VI), biochemist /biophysicist.
Biochimie des Protéines
La biochimie des protéines est une discipline sans cesse dynamisée par l’émergence de nouvelles technologies à la convergence de la chimie, la biophysique, la biologie moléculaire et la biologie cellulaire. Elle regroupe les méthodes […]
Design and optimization of new bioluminescent systems better-suited to in cellulo and in vivo conditions
The use of light from the abyss in life sciences In the last decades, bioluminescent systems based on the expression of a luciferase and the addition of a luciferin to monitor the emission […]
Application of IL7-signaling research to guide diagnostic and therapeutic strategies
When the signaling induced by IL-7 is constitutively altered in patients, we observed lymphopenia when the response is reduced (eg AIDS), and leukemia when it is increased (eg acute lymphoblastic leukemia T-ALL). Comparing the […]
Basic Research – IL7 signaling in T-cells
With the technological support of facilities at the Pasteur Institute and through collaborations with several international institutions, we study the early steps of signaling induced by interleukin-7 on CD4 T lymphocytes (helper). This cytokine […]
2020Core-modified coelenterazine luciferin analogues, synthesis and chemiluminescence properties., Chemistry 2020 Nov; (): .
2020A highly sensitive bioluminescent method for measuring allergen-specific IgE in microliter samples., Allergy 2020 May; (): .
2013Membrane microdomains and cytoskeleton organization shape and regulate the IL-7 receptor signalosome in human CD4 T-cells, J. Biol. Chem. 2013 Mar;288(12):8691-701.
2011Interleukin (IL)-2 and IL-15 have different effects on human natural killer lymphocytes, Hum. Immunol. 2011 Nov;72(11):1013-7.
2010KCNQ1 channels voltage dependence through a voltage-dependent binding of the S4-S5 linker to the pore domain, J. Biol. Chem. 2011 Jan;286(1):707-16.
2010IL-2 induces conformational changes in its preassembled receptor core, which then migrates in lipid raft and binds to the cytoskeleton meshwork, J. Mol. Biol. 2010 Nov;403(5):671-92.
2010Zinc induces structural reorganization of gelatin binding domain from human fibronectin and affects collagen binding, Structure 2010 Jun;18(6):710-8.
2010Elucidation of the self-assembly pathway of lanreotide octapeptide into beta-sheet nanotubes: role of two stable intermediates, J. Am. Chem. Soc. 2010 Mar;132(12):4230-41.
2010Interleukin-7 compartmentalizes its receptor signaling complex to initiate CD4 T lymphocyte response, J. Biol. Chem. 2010 May;285(20):14898-908.
2009Identification and biochemical characterization of human plasma soluble IL-7R: lower concentrations in HIV-1-infected patients, J. Immunol. 2009 Jun;182(12):7389-97.
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