Assistant Professor, CR IP (PhD 1992 Paris XI, HDR 2009 Paris VI), biochemist /biophysicist.
Biochimie des Protéines
La biochimie des protéines est une discipline sans cesse dynamisée par l’émergence de nouvelles technologies à la convergence de la chimie, la biophysique, la biologie moléculaire et la biologie cellulaire. Elle regroupe les méthodes […]
Impact of tissue components on cell migration: adhesion strength, cell morpho-dynamics and intracellular biophysics parameters.
We aim to analyze the impact of substrates on Entamoeba histolytica mode of migration during colonic mucosa invasion using live imaging and quantitative image analysis. E. histolytica, the etiological agent of amoebiasis, is a […]
Design and optimization of new bioluminescent systems better-suited to in cellulo and in vivo conditions
The use of light from the abyss in life sciences In the last decades, bioluminescent systems based on the expression of a luciferase and the addition of a luciferin to monitor the emission […]
Application of IL7-signaling research to guide diagnostic and therapeutic strategies
When the signaling induced by IL-7 is constitutively altered in patients, we observed lymphopenia when the response is reduced (eg AIDS), and leukemia when it is increased (eg acute lymphoblastic leukemia T-ALL). Comparing the […]
Basic Research – IL7 signaling in T-cells
With the technological support of facilities at the Pasteur Institute and through collaborations with several international institutions, we study the early steps of signaling induced by interleukin-7 on CD4 T lymphocytes (helper). This cytokine […]
2021High-risk exposure without personal protective equipment and infection with SARS-CoV-2 in-hospital workers – The CoV-CONTACT cohort., J Infect 2021 05; 82(5): 186-230.
2021Seroprevalence and risk factors of exposure to COVID-19 in homeless people in Paris, France: a cross-sectional study., Lancet Public Health 2021 04; 6(4): e202-e209.
2021Core-Modified Coelenterazine Luciferin Analogues: Synthesis and Chemiluminescence Properties., Chemistry 2021 Jan; 27(6): 2112-2123.
2021Measuring the subcellular compartmentalization of viral infections by protein complementation assay., Proc Natl Acad Sci U S A 2021 01; 118(2): .
2021High seroprevalence but short-lived immune response to SARS-CoV-2 infection in Paris., Eur J Immunol 2021 01; 51(1): 180-190.
2020A highly sensitive bioluminescent method for measuring allergen-specific IgE in microliter samples., Allergy 2020 11; 75(11): 2952-2956.
2020Adenomatous Polyposis Coli Modulates Actin and Microtubule Cytoskeleton at the Immunological Synapse to Tune CTL Functions., Immunohorizons 2020 06; 4(6): 363-381.
2020PLA2G1B is involved in CD4 anergy and CD4 lymphopenia in HIV-infected patients., J Clin Invest 2020 06; 130(6): 2872-2887.
2020Bioluminescence Profiling of NanoKAZ/NanoLuc Luciferase Using a Chemical Library of Coelenterazine Analogues., Chemistry 2020 Jan; 26(4): 948-958.
2019Gram-scale synthesis of luciferins derived from coelenterazine and original insights into their bioluminescence properties., Org Biomol Chem 2019 04; 17(15): 3709-3713.
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