We study the role of the protein-protein interaction domains called PDZ. PDZ domains are scaffold modules regulating the cellular trafficking, the auto-association and the catalytic activity of essential cellular proteins. We have two lines of research: the rabies virus neuronal infection and the mutations in PDZ Binding Motif (PBM)-containing proteins associated to the Usher syndrome.
Signalling and Molecular interactions
Identification of cellular PDZ-containing Proteins targeted by the virus SARS-Cov-2 during infection (PPCOVi)
Thanks to their binding to PDZ domains, viral proteins play an important role in the replication and pathogenesis of SARS-CoV. Through cellular and in vitro high-throughput tests, this project aims to identify the cellular […]
Mutations in PDZ Binding Motif (PBM)-containing proteins associated to the Usher syndrome
Mutations in PDZ Binding Motif (PBM)-containing proteins are also associated to the Usher syndrome, a genetic disease resulting in both hearing loss and visual impairment. Most Usher proteins are present in auditory hair cells […]
Rabies virus neuronal infection
We have shown that proteins from Rabies virus during infection disrupts the interactions of the kinase MAST2 and phosphatase PTPN4 (PDZ domain) with their respective PDZ Binding Motif (PBM)-containing cellular ligands, the phosphatase PTEN […]
2020Dual Specificity PDZ- and 14-3-3-Binding Motifs: A Structural and Interactomics Study, Structure 2020 Apr;.
2019Identification of protein-protein and ribonucleoprotein complexes containing Hfq, Sci Rep 2019 Oct;9(1):14054.
2019Structure-based optimization of a PDZ-binding motif within a viral peptide stimulates neurite outgrowth, J. Biol. Chem. 2019 Sep;294(37):13755-13768.
2019Structural and functional characterization of the PDZ domain of the human phosphatase PTPN3 and its interaction with the human papillomavirus E6 oncoprotein, Sci Rep 2019 May;9(1):7438.
2019High-Throughput Production of a New Library of Human Single and Tandem PDZ Domains Allows Quantitative PDZ-Peptide Interaction Screening Through High-Throughput Holdup Assay, Methods Mol. Biol. 2019;2025:439-476.
2018Structural plasticity of the HHD2 domain of whirlin, FEBS J. 2018 10;285(20):3738-3752.
2017Interfering peptides targeting protein-protein interactions: the next generation of drugs?, Drug Discov. Today 2018 Feb;23(2):272-285.
2017Structural Characterization of Whirlin Reveals an Unexpected and Dynamic Supramodule Conformation of Its PDZ Tandem, Structure 2017 11;25(11):1645-1656.e5.
2017Regulation of the Human Phosphatase PTPN4 by the inter-domain linker connecting the PDZ and the phosphatase domains, Sci Rep 2017 Aug;7(1):7875.
2017Conformational switch of harmonin, a submembrane scaffold protein of the hair cell mechanoelectrical transduction machinery, FEBS Lett. 2017 08;591(15):2299-2310.
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