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  • Director of Center
  • Director of Department
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About

The team is interested in the disruption of signaling pathways by pathogens and genetic diseases. The recognition of PDZ domains is common to all research subjects either in viral disruption processes or in auditory signal transduction.
We study the role of the protein-protein interaction domains called PDZ. PDZ domains are scaffold modules regulating the cellular trafficking, the auto-association and the catalytic activity of essential cellular proteins.

Former Members

2000
2000
Name
Position
2010
2017
Florence Cordier
Permanent Researcher
2015
2020
Virginie Girault
Research Engineer
2015
2020
Florent Delhommel
PhD Student
2015
2020
Damien Samson
Master 2 student
2015
2020
Juan Ramon Ramirez Ramos
Post-doc
2015
2020
Alain Chaffotte
Permanent Researcher
2015
2020
Emilie (de La Llave) Giraud
Post-doc
2015
2020
Tiziana Lo Campo
Undergraduate Student
2016
2019
Mariano Genera
PhD Student
2020
2020
Gabrielle Dejean de la Batie
Master 2 student

Projects

Project
Ongoing
2 Members

Myosins-Usher2 proteins complexes in hearing loss

Célia Caillet-Saguy (PI)

The Usher syndrome (USH) is the main genetic disorder characterized by congenital hearing loss associated with progressive visual impairment. In the healthy person, each cochlear sensory cell from the inner ear presents hair bundles […]
Project
Ongoing
3 Members

Identification of cellular PDZ-containing Proteins targeted by the virus SARS-Cov-2 during infection (PPCOVi)

Nicolas Wolff (PI)

Thanks to their binding to PDZ domains, viral proteins play an important role in the replication and pathogenesis of SARS-CoV. Through cellular and in vitro high-throughput tests, this project aims to identify the cellular […]
Project
Ongoing
5 Members

Mutations in PDZ Binding Motif (PBM)-containing proteins associated to the Usher syndrome

Nicolas Wolff (PI)

Mutations in PDZ Binding Motif (PBM)-containing proteins are also associated to the Usher syndrome, a genetic disease resulting in both hearing loss and visual impairment. Most Usher proteins are present in auditory hair cells […]
Project
Ongoing
4 Members

Rabies virus neuronal infection

Nicolas Wolff (PI)

We have shown that proteins from Rabies virus during infection disrupts the interactions of the kinase MAST2 and phosphatase PTPN4 (PDZ domain) with their respective PDZ Binding Motif (PBM)-containing cellular ligands, the phosphatase PTEN […]

Fundings

Publications

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Contact

Phone:+33 1 45 68 88 72 Email:nicolas.wolff@pasteur.fr Address 25-28 Rue du Docteur Roux 75015, Paris France