We study the role of the protein-protein interaction domains called PDZ. PDZ domains are scaffold modules regulating the cellular trafficking, the auto-association and the catalytic activity of essential cellular proteins. We have two lines of research: the rabies virus neuronal infection and the mutations in PDZ Binding Motif (PBM)-containing proteins associated to the Usher syndrome.
Mutations in PDZ Binding Motif (PBM)-containing proteins associated to the Usher syndrome
Mutations in PDZ Binding Motif (PBM)-containing proteins are also associated to the Usher syndrome, a genetic disease resulting in both hearing loss and visual impairment. Most Usher proteins are present in auditory hair cells […]
Rabies virus neuronal infection
We have shown that proteins from Rabies virus during infection disrupts the interactions of the kinase MAST2 and phosphatase PTPN4 (PDZ domain) with their respective PDZ Binding Motif (PBM)-containing cellular ligands, the phosphatase PTEN […]
2017Structural Characterization of Whirlin Reveals an Unexpected and Dynamic Supramodule Conformation of Its PDZ Tandem, Structure 2017 Nov;25(11):1645-1656.e5.
2017Regulation of the Human Phosphatase PTPN4 by the inter-domain linker connecting the PDZ and the phosphatase domains, Sci Rep 2017 Aug;7(1):7875.
2017Conformational switch of harmonin, a submembrane scaffold protein of the hair cell mechanoelectrical transduction machinery, FEBS Lett. 2017 08;591(15):2299-2310.
2016(1)H, (13)C and (15)N backbone resonance assignments and dynamic properties of the PDZ tandem of Whirlin, Biomol NMR Assign 2016 Oct;10(2):361-5.
2016Molecular Basis of the Interaction of the Human Protein Tyrosine Phosphatase Non-receptor Type 4 (PTPN4) with the Mitogen-activated Protein Kinase p38γ, J. Biol. Chem. 2016 Aug;291(32):16699-708.
2015Quantifying domain-ligand affinities and specificities by high-throughput holdup assay, Nat. Methods 2015 Aug;12(8):787-93.
2015Deciphering the unconventional peptide binding to the PDZ domain of MAST2, Biochem. J. 2015 Jul;469(1):159-68.
2015Strategies to interfere with PDZ-mediated interactions in neurons: What we can learn from the rabies virus, Prog. Biophys. Mol. Biol. 2015 Oct;119(1):53-9.
2014Quantitative and dynamic analysis of PTEN phosphorylation by NMR, Methods 2015 May;77-78:82-91.
2014Regulation of the catalytic activity of the human phosphatase PTPN4 by its PDZ domain, FEBS J. 2014 Nov;281(21):4852-65.
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