The team is interested in the disruption of signaling pathways by pathogens and genetic diseases. The recognition of PDZ domains is common to all research subjects either in viral disruption processes or in auditory signal transduction.
We study the role of the protein-protein interaction domains called PDZ. PDZ domains are scaffold modules regulating the cellular trafficking, the auto-association and the catalytic activity of essential cellular proteins.
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Connections
Members
Groups
Group
Signalling and Molecular interactions
Nicolas Wolff
Former Members
2000
2000
Name
Position
2010
2017
Florence Cordier
Permanent Researcher
2015
2020
Virginie Girault
Research Engineer
2015
2020
Florent Delhommel
PhD Student
2015
2020
Damien Samson
Master 2 student
2015
2020
Juan Ramon Ramirez Ramos
Post-doc
2015
2020
Alain Chaffotte
Permanent Researcher
2015
2020
Emilie (de La Llave) Giraud
Post-doc
2015
2020
Tiziana Lo Campo
Undergraduate Student
2016
2019
Mariano Genera
PhD Student
2020
2020
Gabrielle Dejean de la Batie
Master 2 student
Projects
Fundings
Publications
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2022Interactions of Severe Acute Respiratory Syndrome Coronavirus 2 Protein E With Cell Junctions and Polarity PSD-95/Dlg/ZO-1-Containing Proteins., Front Microbiol 2022 ; 13(): 829094.
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2021PDZ-Containing Proteins Targeted by the ACE2 Receptor., Viruses 2021 11; 13(11): .
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2021Host PDZ-containing proteins targeted by SARS-Cov-2., FEBS J 2021 Apr; (): .
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2021Phylogenetic analysis of Harmonin homology domains., BMC Bioinformatics 2021 Apr; 22(1): 190.
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2021Role of PDZ-binding motif from West Nile virus NS5 protein on viral replication., Sci Rep 2021 Feb; 11(1): 3266.
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2021Molecular basis of the interaction of the human tyrosine phosphatase PTPN3 with the hepatitis B virus core protein., Sci Rep 2021 Jan; 11(1): 944.
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2021PDZ Sample Quality Assessment by Biochemical and Biophysical Characterizations., Methods Mol Biol 2021 ; 2256(): 89-124.
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2021Automatic Bayesian Weighting for SAXS Data., Front Mol Biosci 2021 ; 8(): 671011.
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2020Ultrarare heterozygous pathogenic variants of genes causing dominant forms of early-onset deafness underlie severe presbycusis., Proc Natl Acad Sci U S A 2020 12; 117(49): 31278-31289.
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2020Deciphering the Unexpected Binding Capacity of the Third PDZ Domain of Whirlin to Various Cochlear Hair Cell Partners., J Mol Biol 2020 11; 432(22): 5920-5937.
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Contact
Phone:+33 1 45 68 88 72 Email:nicolas.wolff@pasteur.fr Address 25-28 Rue du Docteur Roux 75015, Paris France