We study the role of the protein-protein interaction domains called PDZ. PDZ domains are scaffold modules regulating the cellular trafficking, the auto-association and the catalytic activity of essential cellular proteins. We have two lines of research: the rabies virus neuronal infection and the mutations in PDZ Binding Motif (PBM)-containing proteins associated to the Usher syndrome.
Signalling and Molecular interactions
Myosins-Usher2 proteins complexes in hearing loss
The Usher syndrome (USH) is the main genetic disorder characterized by congenital hearing loss associated with progressive visual impairment. In the healthy person, each cochlear sensory cell from the inner ear presents hair bundles […]
Identification of cellular PDZ-containing Proteins targeted by the virus SARS-Cov-2 during infection (PPCOVi)
Thanks to their binding to PDZ domains, viral proteins play an important role in the replication and pathogenesis of SARS-CoV. Through cellular and in vitro high-throughput tests, this project aims to identify the cellular […]
Mutations in PDZ Binding Motif (PBM)-containing proteins associated to the Usher syndrome
Mutations in PDZ Binding Motif (PBM)-containing proteins are also associated to the Usher syndrome, a genetic disease resulting in both hearing loss and visual impairment. Most Usher proteins are present in auditory hair cells […]
Rabies virus neuronal infection
We have shown that proteins from Rabies virus during infection disrupts the interactions of the kinase MAST2 and phosphatase PTPN4 (PDZ domain) with their respective PDZ Binding Motif (PBM)-containing cellular ligands, the phosphatase PTEN […]
2021Host PDZ-containing proteins targeted by SARS-Cov-2., FEBS J 2021 Apr; (): .
2021Phylogenetic analysis of Harmonin homology domains., BMC Bioinformatics 2021 Apr; 22(1): 190.
2021Role of PDZ-binding motif from West Nile virus NS5 protein on viral replication., Sci Rep 2021 Feb; 11(1): 3266.
2021Molecular basis of the interaction of the human tyrosine phosphatase PTPN3 with the hepatitis B virus core protein., Sci Rep 2021 Jan; 11(1): 944.
2021PDZ Sample Quality Assessment by Biochemical and Biophysical Characterizations., Methods Mol Biol 2021 ; 2256(): 89-124.
2021Automatic Bayesian Weighting for SAXS Data., Front Mol Biosci 2021 ; 8(): 671011.
2020Ultrarare heterozygous pathogenic variants of genes causing dominant forms of early-onset deafness underlie severe presbycusis., Proc Natl Acad Sci U S A 2020 12; 117(49): 31278-31289.
2020Deciphering the Unexpected Binding Capacity of the Third PDZ Domain of Whirlin to Various Cochlear Hair Cell Partners., J Mol Biol 2020 11; 432(22): 5920-5937.
2020Interaction of protocadherin-15 with the scaffold protein whirlin supports its anchoring of hair-bundle lateral links in cochlear hair cells., Sci Rep 2020 Oct; 10(1): 16430.
2020Hidden kinetic traps in multidomain folding highlight the presence of a misfolded but functionally competent intermediate., Proc Natl Acad Sci U S A 2020 08; 117(33): 19963-19969.
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