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  • center
  • program_project
  • nrc
  • whocc
  • project
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  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Clinician Researcher
  • Department Manager
  • Full Professor
  • Graduate Student
  • Honorary Professor
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Prize
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
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About

The team is interested in the disruption of signaling pathways by pathogens and genetic diseases. The recognition of PDZ domains is common to all research subjects either in viral disruption processes or in auditory signal transduction.
We study the role of the protein-protein interaction domains called PDZ. PDZ domains are scaffold modules regulating the cellular trafficking, the auto-association and the catalytic activity of essential cellular proteins.

Projects

Project
Ongoing
2 Members

Hijacking of host PDZ proteins during hepatitis B virus infection

Célia Caillet-Saguy (PI)

Hepatitis B virus (HBV) infection is a major global public health problem. Effective prophylaxis by vaccination is available for more than 20 years. Despite this, chronic hepatitis B is still an incurable disease. The […]
Project
Ongoing
2 Members

Myosins-Usher2 proteins complexes in hearing loss

Célia Caillet-Saguy (PI)

The Usher syndrome (USH) is the main genetic disorder characterized by congenital hearing loss associated with progressive visual impairment. In the healthy person, each cochlear sensory cell from the inner ear presents hair bundles […]
Project
Ongoing
3 Members

Identification of cellular PDZ-containing Proteins targeted by the virus SARS-Cov-2 during infection (PPCOVi)

Nicolas Wolff (PI)

Thanks to their binding to PDZ domains, viral proteins play an important role in the replication and pathogenesis of SARS-CoV. Through cellular and in vitro high-throughput tests, this project aims to identify the cellular […]
Project
Ongoing
5 Members

Mutations in PDZ Binding Motif (PBM)-containing proteins associated to the Usher syndrome

Nicolas Wolff (PI)

Mutations in PDZ Binding Motif (PBM)-containing proteins are also associated to the Usher syndrome, a genetic disease resulting in both hearing loss and visual impairment. Most Usher proteins are present in auditory hair cells […]
Project
Ongoing
2 Members

Rabies virus neuronal infection

Nicolas Wolff (PI)

We have shown that proteins from Rabies virus during infection disrupts the interactions of the kinase MAST2 and phosphatase PTPN4 (PDZ domain) with their respective PDZ Binding Motif (PBM)-containing cellular ligands, the phosphatase PTEN […]

Fundings

Publications

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Contact

Phone:+33 1 45 68 88 72 Email:nicolas.wolff@pasteur.fr Address 25-28 Rue du Docteur Roux 75015, Paris France