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  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Clinician Researcher
  • Department Manager
  • Full Professor
  • Graduate Student
  • Honorary Professor
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Prize
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
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About

The platform’s ambition is to develop serological or antigenic in vitro diagnostic test (IVD) as fast as possible, since 2020 for SARS-CoV-2, today for other viral, microbial or parasitic infectious agents, and tomorrow for global health applications on human, animal and environmental samples. The cross-disciplinary talents of our team weave together physics, chemistry, biology and engineering to imagine and design these diagnostic health tests of the future.

 

Our missions ?

  • To remain responsive to health or environmental emergencies and studies, in collaboration with GOs, NGOs and hospitals, with point-of-need or very high throughput solutions for epidemiological or clinical studies
  • Identify needs by listening to patients, their caregivers and experts, in collaboration with research and health institutions
  • Develop innovations in collaboration with deeptech start-ups and industries, evaluate reagents, methods and technologies on reference samples, identify their fields of application, and validate their suitability for the needs of the healthcare ecosystem
  • Support the development of innovations by the Institut Pasteur teams and its network on reagents, methods or technologies and ease their transfer in the health system and industry.
  • Train the engineers of the future

 

Our resources ?

The platform has state-of-the-art equipment to :

  • Transfer and replicate samples from tubes to plates, plates to plates and plates to chips
  • Perform up to 2300 serological or antigenic ELISA or LuLISA tests per hour
  • Quantify markers, reporters or reaction products by absorbance, fluorescence, luminescence or any spectral combination
  • Design, develop, produce and evaluate rapid immunoassays on strips, slides, arrays or beads
  • Design and produce antibodies coupled to luciferases, fluorescent proteins, peroxidases, Qdots, nanogold
  • Manufacture demonstrators for the innovation of test devices and reading technologies

 

Our ambitions ?

  • To select and produce specific molecular probes for any biomarker in 50 days that can be used in a high throughput test or a point-of-care test without animal immunization
  • Develop robust and sensitive solutions to test the presence of several hundred different biomarkers with the same sample (allergies, cancers, infections and inflammation)
  • Become an innovative and inspiring player in the diagnostic industry
  • Become a resource for clinical, epidemiological and environmental studies and a force for action in pandemic surveillance

 

Our successes ?

  • Goyard et al. A highly sensitive bioluminescent method for measuring allergen-specific IgE in microliter samples. Allergy. 2020. 75:2952-2956
  • Le Vu et al. Prevalence of SARS-CoV-2 antibodies in France: results from nationwide serological surveillance. Nat Commun. 2021. 12:3025
  • Roederer et al. Seroprevalence of SARS-CoV-2 IgG antibodies and risk factors of exposure in Paris: a study among homeless and precariously housed people. The lancet Public Health e202-e209
  • Anna et al. High throughput serology and pseudo-neutralization tests reveal high prevalence but short live response to SARS-CoV-2 infection in a large healthy worker cohort in May-June 2020 in Paris. Eur J Immunol. 2021. 51: 180–190

 

Our internship offers ?

  • Manufacturing : Prototyping a standalone instant test terminal during a 6 months internship in last year of engineering school in electrical engineering, mechanical engineering, embedded electronics, robotics
  • Manufacturing : Prototyping a mobile test strip reader during a 6 months internship in the last year of engineering school in electrical engineering, mechanical engineering, embedded electronics, robotics
  • Manufacturing : prototyping an automated system for loading tips with antibody-functionalized resins for high performance separation of biomarkers for mass-spectrometry quantitfication from body fluids during a 6 months internship in the last year of engineering school in robotics or biotechnology
  • Process : Development of a therapeutic monitoring test on a drop of dried blood during a 6 months internship in the last year of engineering school in biotechnology
  • Big data/AI : Evaluation of the severity of allergic reactions by deep learning during a 6 months internship in the last year of a general engineering school with a focus on mathematics and/or computer science

 

Contact us ?

Email : diag@pasteur.fr

Former Members

  • Amandine Schneider – 3rd year student in mechanic engineering (2020, INSA Lyon)
  • Jerko Ljubetic – 3rd year student in Math/Physics engineering (2021, Centrale-Supélec)
  • Karla Dedeler – 1st year engineering student (2022, IMT Atlantique)
  • Killian Collins – 2nd year student in biotechnology and chemistry (2022, CY Tech Cergy Pontoise)
  • Manuel Sanchez-Laguardia – 2nd year student in electric engineering (2022, IMT Atlantique)
  • Guillaume Le Floch – 2nd year student in DUT Mesures Physiques (2022, Paris Saclay University)
  • Margaux Nussbaumer – 2nd year engineering student in robotics (2022, IMT Atlantique)
  • Séverine Daniel – 2nd year engineering student  (2022, IMT Atlantique)
  • Jason Maureille – 2nd year engineering student in data science (2022, IMT Atlantique)
  • Sofia Trujillo – 1st year student engineer in biotechnology (2022, INSA Lyon)

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