I did my Master and my PhD in the NMR unit of Biomolecules headed by Mrs. Delepierre at the Institut Pasteur. My thesis focused on the study of heme acquisition mechanism in bacteria. I used biophysical approaches, mainly nuclear magnetic resonance (NMR).
I joined for my post-doc the team of biocrystallography led by Stéphane Bressanelli in the Molecular and Structural Virology Unit directed by Yves Gaudin (Gif-sur-Yvette). My project focused on the study of genome replication of hepatitis C virus (HCV). I acquired a dual expertise in NMR and X-ray crystallography.
Then I joined the team of Nicolas Wolff. I worked on the functional and structural characterization of the human phosphatase PTPN4. Now I develop a new project within the group on anti-proliferative human phosphatase PTPN3. I am also involved in a project with Nicolas Wolff on viral hijacking of PDZ proteins among flaviviruses. More generally, I am interested in disturbance by viruses of the signaling pathways of the infected cell involving PDZ domains.
Our group has joined the Channel Receptors unit since January 2018 led by Pierre-Jean Corringer (Department of Neuroscience).
Rabies virus neuronal infection
We have shown that proteins from Rabies virus during infection disrupts the interactions of the kinase MAST2 and phosphatase PTPN4 (PDZ domain) with their respective PDZ Binding Motif (PBM)-containing cellular ligands, the phosphatase PTEN […]
Role of PDZ-binding motif from Flavivirus non-structural proteins in flaviviral life cycle
Arthropod-borne viruses (arboviruses) include numerous human and animal pathogens that are important global health threats. Flaviviruses are arboviruses belonging to the Flaviviridae family. They include neurotropic viruses such as West Nile (WNV), Japanese encephalitis […]